SUMMARY OBJECTIVE: Beta-thalassemia minor is a blood disease caused by a hereditary decrease in beta-globin synthesis, frequently leading to hypochromic microcytic anemia. Formerly called endothelial cell-specific molecule 1, endocan is a proteoglycan released by vascular endothelial cells in many organ...
Abstract The study investigated the relationship between genetic polymorphisms and the development of oral mucositis in pediatric patients undergoing chemotherapy involving methotrexate. A longitudinal study was conducted with 64 patients, and oral mucositis was evaluated by the modified Oral Assessment ...
Abstract: Endocan, a 50 kDa soluble proteoglycan, also called endothelial cell-specific molecule-1 (ESM-1), is involved in many major cellular activities and has been reported to be overexpressed in inflammatory conditions. This study aims to determine ESM-1 levels in gingival crevicular fluid (GCF) samp...
Abstract Objective To investigate the association between genetic polymorphisms in candidate genes or candidate regions and the development of endometriosis in Brazilian women. Methods A total of 30 women between 25 and 64 years old with a diagnosis of endometriosis participated in the present study, a...
BACKGROUND: Prognosis remains one of most crucial determinants of gastric cancer (GC) treatment, but current methods do not predict prognosis accurately. Identification of additional biomarkers is urgently required to identify patients at risk of poor prognoses. METHODS: Tissue microarrays were used to m...
Biomarcadores de Tumor/metabolismo,
Proteínas de Neoplasias/metabolismo,
Neoplasias Gástricas/mortalidad,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Estadificación de Neoplasias,
Pronóstico,
Análisis de Supervivencia,
Análisis de Matrices Tisulares
BACKGROUND: The purpose of the present study was to investigate the role of the methylation status of the DACT1 gene on the invasion and metastasis of nasopharyngeal carcinoma cells. METHODS: The levels of methylation and expression of the DACT1 gene in nasopharyngeal carcinoma tissues and CNE2 cells wer...
Proteínas Adaptadoras Transductoras de Señales/genética,
Metilación de ADN/genética,
Carcinoma Nasofaríngeo/secundario,
Neoplasias Nasofaríngeas/patología,
Proteínas Nucleares/genética,
Proteínas Adaptadoras Transductoras de Señales/metabolismo,
Metilación de ADN/fisiología,
Carcinoma Nasofaríngeo/genética,
Neoplasias Nasofaríngeas/genética,
Proteínas de Neoplasias/metabolismo,
Proteínas Nucleares/metabolismo,
Invasividad Neoplásica,
Regiones Promotoras Genéticas
ABSTRACT Background : It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis. Aim : To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma. Method : The immunohistochemistry was performed in 72 specimen...
Proteína Axina/análisis,
Carcinogénesis,
Carcinoma/química,
Carcinoma/patología,
Quinasa de la Caseína I/análisis,
Ciclina D1/análisis,
Receptores Frizzled/análisis,
Glucógeno Sintasa Quinasa 3 beta/análisis,
Inmunohistoquímica,
Proteínas de Neoplasias/análisis,
Estadificación de Neoplasias,
Proteínas Proto-Oncogénicas c-myc/análisis,
Valores de Referencia,
Neoplasias Gástricas/química,
Neoplasias Gástricas/patología,
Ubiquitina/análisis,
Vía de Señalización Wnt,
Proteína Wnt-5a/análisis
Abstract Objective The aim of the present study was to analyze the expression of the CD63, S100A6, and GNB2L1genes, which participate in mechanisms related to the complex pathophysiology of endometriosis. Methods A case-control study was conducted with 40 women who were diagnosed with endometriosis, ...
Apoptosis/genética,
Estudios de Casos y Controles,
Proteínas de Ciclo Celular/genética,
Proliferación Celular/genética,
Endometriosis/genética,
Endometriosis/patología,
Expresión Génica,
Proteínas de Neoplasias/genética,
Neovascularización Patológica/genética,
Receptores de Cinasa C Activada/genética,
Proteína A6 de Unión a Calcio de la Familia S100/genética,
Tetraspanina 30/genética
Abstract Objective To analyze endocan-1, a biomarker of vascular endothelial related pathologies, and the placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with preeclampsia (PE). Methods Case-control study conducted at Hospital São Lucas, in the cit...
Adenocarcinoma/sangre,
Adenocarcinoma/diagnóstico,
Adenocarcinoma/economía,
Antígenos de Neoplasias/sangre,
Biomarcadores de Tumor/sangre,
Región del Caribe,
Análisis Costo-Beneficio,
Países en Desarrollo/economía,
Detección Precoz del Cáncer/economía,
América Latina,
Proteínas de Neoplasias/sangre,
Neoplasias de la Próstata/sangre,
Neoplasias de la Próstata/diagnóstico,
Neoplasias de la Próstata/economía,
Sensibilidad y Especificidad
