Results: 12

Moderate Toxicity of Potential Boron-containing Therapeutic, Dipotassium-trioxohydroxytetrafl uorotriborate - K2 (B3 O3 F4 OH) in Rats and Mice

Abstract Biological activity of boron-containing compounds (BCCs) has been well-known. Growing interest and numerous applications for BCCs have been reported. Boron and boron-containing acids show low acute toxicity in mammals but data on halogenated boroxine (HB) - dipotassium-trioxohydroxytetrafluorotr...

Anti-inflammatory effects and acute oral toxicity of Copaifera spp. essential oil-loaded nanoemulsion

Copaifera spp. essential oil (EOC) was extracted by hydrodistillation of Copaifera oleoresin (COR). The EOC was characterized by GC/MS and a novel EOC-loaded nanoemulsion was developed to enhance the EOC solubility and to evaluate its utility as antinflammatory. EOC contain 14 volatile compounds (includ...

Preclinical studies of hydroalcoholic extract of Calea uniflora Less

Acta toxicol. argent; 27 (2), 2019
Calea uniflora Less known popularly as Arnica in Brazil, is a native plant from Brazil, popular used by coastal populations from south of Santa Catarina. The purpose of this study was to verify the safety profile in of hydroalcoholic extract of C. uniflora in florescences.The hydroalcoholic extract of C....

Acute toxicity study of a polysaccharide based hydrogel from linseed for potential use in drug delivery system

ABSTRACT Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left un...

Toxicidad a dosis repetidas (28 días) por vía oral del agua termomineral de San Antonio de Putina, Puno
Repeated dose 28-day oral toxicity study of hot springs water from San Antonio de Putina, Puno

Objetivo. Determinar la toxicidad a dosis repetidas durante 28 días, de la ingestión por vía oral del agua termal de San Antonio de Putina-SAP-(Puno), en un modelo murino. Materiales y métodos. Diseño experimental, se utilizaron diez ratas de experimentación de cepa Holtzman, los que fueron dividid...

Ecotoxicidad de nanopartículas metálicas y superparamagnéticas de óxido de hierro en dos especies
Ecotoxicity of metalic and superparamagnetics iron oxide nanoparticles in two species

Rev. cuba. med. mil; 46 (2), 2017
Introducción: la nanotecnología y el empleo de materiales a nano escala son un área relativamente nueva de la ciencia y la tecnología con un gran crecimiento en el mercado global. Muchos de los productos no cuentan con estudios que garanticen su uso seguro, tanto para el hombre como para los ecosiste...

Ensaios pré-clínicos em ratos tratados com 1, 3-diestearil-2-oleilglicerol, constituinte isolado de Platonia insignis

Introdução: Avaliou-se a toxicidade aguda de 1,3-diestearil-2-oleil-glicerol (TG1), composto obtido de Platonia insignis Mart. (bacurizeiro), após administração oral em ratos Wistar. Métodos: A toxicidade aguda foi analisada através dos parâmetros hematológicos e bioqu...

Isolation of the intracellular and extracellular polysaccharides of Ganoderma neojaponicum (Imazeki) and characterization of their immunomodulatory properties

Electron. j. biotechnol; 18 (3), 2015
Background The role of polysaccharides isolated from the Ganoderma species of fungi in innate immunity has recently become a topic of research. Although some work has been conducted concerning Ganoderma lucidum, the characteristics of polysaccharides isolated from Ganoderma neojaponicum (Imazeki) as immu...

Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation

Biol. Res; 47 (), 2014
BACKGROUND: The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. RESULTS: The AELS and AEAR extract presented a significant (***p < 0.001) dose dependent...

Estudio comparativo in vitro de la actividad antibacteriana de los extractos secos hidroalcohólicos al 70% de las hojas de Psidium guajava (Sahuinto) y Chenopodium ambrosioides (Paico) frente a bacterias que causan infecciones de las vías respiratorias y determinación de la toxicidad aguda en animales de experimentación
Comparative study in vitro of the antibacterial activity of the dry hydroalcoholic extracts to 70% of the leaves of Psidium guajava (Sahuinto) and Chenopodium ambrosioides (Paico) against bacteria that cause respiratory tract infections and determination of acute toxicity in animals of experimentation

El siguiente Trabajo de Investigación se realizó con el objeto de determinar y comparar la Actividad Antibacteriana In Vitro de los Extractos Secos Hidroalcohólicos al 70% de las Hojas de las especies vegetales Psidium guajava "Sahuinto" y Chenopodium ambrosioides "Paico" frente a cepas A TCC de bacte...