Abstract Sugammadex is a distinctive neuromuscular reversal drug that acts by encapsulating the neuromuscular relaxant molecule and dislodging it from its site of action. Sugammadex has been approved for pediatric patients over 2 years of age. Although arrhythmias have been reported, there is no report o...
Abstract Background and objectives: Sugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that are related to treatment with sugammadex were reported. The exact mechanis...
Anestesia/métodos,
Anestésicos por Inhalación,
Coagulación Sanguínea/efectos de los fármacos,
Combinación de Medicamentos,
Fibrinógeno/análisis,
Isoflurano,
Bloqueo Neuromuscular,
Fármacos Neuromusculares no Despolarizantes/administración & dosificación,
Fármacos Neuromusculares no Despolarizantes/farmacología,
Tiempo de Tromboplastina Parcial,
Recuento de Plaquetas,
Tiempo de Protrombina,
Distribución Aleatoria,
Ratas Wistar,
Rocuronio/administración & dosificación,
Rocuronio/farmacología,
Sugammadex/administración & dosificación,
Sugammadex/farmacología
Abstract Background: Sugammadex has made it possible to reverse any type of rocuronium-induced block quickly and safely. The most frequent neuromuscular blockade is the moderate one where doses smaller than those recommended by the industry could get a full reversal. Objective: We aimed to evaluate the...
Abstract Heart transplantation is a frequent procedure in the treatment of end-stage cardiac dysfunction. Therefore, these patient populations will also be more frequent exposed to other more common surgical procedures after their transplantation. Anesthesiologist should be aware in their assessment of t...
Myotonic dystrophy is an uncommon disease, characterised by disorders of the muscle membrane. Its clinical manifestations are muscle weakness, difficulty at initiating movements and delayed muscle relaxation. Carriers of this disease are very sensitive to anaesthetic drugs. Residual neuromuscular blockad...
Abstract Objectives Reductions in diaphragm activity are associated with the postoperative development of atelectasis. Neostigmine reversal is also associated with increased atelectasis. We assessed the effects of neostigmine, sugammadex, and spontaneous reversal on regional lung ventilation and airway ...
Periodo de Recuperación de la Anestesia,
Inhibidores de la Colinesterasa/farmacología,
Pulmón/diagnóstico por imagen,
Pulmón/efectos de los fármacos,
Pulmón/fisiología,
Neostigmina/farmacología,
Bloqueo Neuromuscular,
Proyectos Piloto,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Respiración/efectos de los fármacos,
Sugammadex/farmacología
Abstract Background and objectives: The aim of our study is to compare the effects of sugammadex and neostigmine, used for neuromuscular blockage antagonism, on postoperative nausea and vomiting (PONV). Methods: Our study was completed with 98 ASA I-II risk patients undergoing endotracheal intubation u...
Abstract Myasthenia gravis is an autoimmune disorder that is characterized by muscle weakness that fluctuates, worsening with exertion, and improving with rest. Diagnosis of myasthenia gravis is made following clinical and physical examination and is confirmed by serum immunoassays to measure autoantibod...
ABSTRACT Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery. Methods: we conducted a prospective study with the biased c...
