A obesidade tem causa multifatorial que atinge atualmente mais da metade da população brasileira. Mais recentemente, a microbiota intestinal foi considerada um fator que contribui para essa condição. Os objetivos deste estudo foram revisar a influência da microbiota intestinal na obesidade e no proc...
The interplay between obesity and gastrointestinal (GI) motility is contradictory, and the transgenerational influence on this parameter is unknown. We aimed to evaluate the GI function in a model of paternal obesity and two subsequent generations of their male offspring. Newborn male rats were treated w...
The goal of this study was to describe the gastrointestinal transit technique in the Boa constrictor amarali. For that purpose, we obtained simple radiographic images of seven serpents, subsequently administering a 25mL/kg dose of barium sulfate and establishing a radiographic sequence at the following t...
Abstract Introduction: Anorectal physiology tests are indicated for patients who have refractory symptoms of constipation, but the best sequence of investigation remains controversial. Objective: To evaluate the influence of colonic transit time and anorectal manometry in the diagnosis of chronic const...
ABSTRACT Background: Gastrointestinal disorders are frequently reported in patients with Parkinson's disease whose disorders reduce the absorption of nutrients and drugs, worsening the clinical condition of patients. However, the mechanisms involved in modifying gastrointestinal pathophysiology have not...
ABSTRACT Objective To investigate the effects of sericin extracted from silkworm Bombyx mori cocoon on morphophysiological parameters in mice with obesity induced by high-fat diet. Methods Male C57Bl6 mice aged 9 weeks were allocated to one of two groups - Control and Obese, and fed a standard or hig...
Tejido Adiposo/patología,
Fármacos Antiobesidad/farmacología,
Fármacos Antiobesidad/uso terapéutico,
Peso Corporal/efectos de los fármacos,
Colesterol/análisis,
Dieta Alta en Grasa/efectos adversos,
Ingestión de Alimentos/efectos de los fármacos,
Hígado Graso/patología,
Tránsito Gastrointestinal/efectos de los fármacos,
Prueba de Tolerancia a la Glucosa,
Hígado/metabolismo,
Ratones Endogámicos C57BL,
Ratones Obesos,
Obesidad/tratamiento farmacológico,
Obesidad/etiología,
Obesidad/fisiopatología,
Reproducibilidad de los Resultados,
Sericinas/farmacología,
Factores de Tiempo,
Resultado del Tratamiento,
Triglicéridos/análisis,
Aumento de Peso/efectos de los fármacos,
Sericinas/uso terapéutico
Abstract Purpose: To evaluate the effects of infliximab on the inflammation of the colonic mucosa devoid from fecal stream. Methods: Twenty-four rats were submitted to a Hartmann's procedure. They remained for 12 weeks with the fecal derivation to development of diversion colitis on excluded colorectal...
Colitis/tratamiento farmacológico,
Colitis/patología,
Colon/efectos de los fármacos,
Colon/patología,
Heces,
Fármacos Gastrointestinales/farmacología,
Tránsito Gastrointestinal/efectos de los fármacos,
Procesamiento de Imagen Asistido por Computador,
Inmunohistoquímica,
Infliximab/farmacología,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/patología,
Infiltración Neutrófila/efectos de los fármacos,
Peroxidasa/análisis,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
Abstract Purpose: To evaluate the inflammatory reaction and measure the content of mucins, in the colonic mucosa without fecal stream submit to intervention with mesalazine. Methods: Twenty-four rats were submitted to a left colostomy and a distal mucous fistula and divided into two groups according t...
Antiinflamatorios no Esteroideos/farmacología,
Antiinflamatorios no Esteroideos/uso terapéutico,
Colitis/patología,
Colitis/prevención & control,
Colon/efectos de los fármacos,
Colon/metabolismo,
Colon/patología,
Colostomía,
Enema/métodos,
Heces,
Tránsito Gastrointestinal,
Histocitoquímica,
Procesamiento de Imagen Asistido por Computador,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/metabolismo,
Mucosa Intestinal/patología,
Mesalamina/farmacología,
Mesalamina/uso terapéutico,
Mucinas/análisis,
Mucinas/efectos de los fármacos,
Estrés Oxidativo,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
RESUMEN Objetivos. Evaluar el efecto del endospermo de semilla de tara (EST) y polvo de hojas del Agave americana (HAA) sobre el peso corporal y velocidad de tránsito intestinal en ratas Holtzman. Materiales y métodos Veinticinco ratas machos Holtzman distribuidas en cinco grupos y alojadas en jaul...
Agave,
Peso Corporal/efectos de los fármacos,
Caesalpinia,
Tránsito Gastrointestinal/efectos de los fármacos,
Extractos Vegetales/farmacología,
Endospermo,
Tránsito Gastrointestinal/fisiología,
Hojas de la Planta,
Polvos,
Ratas Sprague-Dawley,
Semillas,
Factores de Tiempo
OBJECTIVES: Several compounds characterized by an olefin linkage conjugated to a carbonyl group have anti-inflammatory properties. The diuretic ethacrynic acid (EA) is a compound of this type. Herein, we tested the hypothesis that ethacrynic acid can modulate the development of ileus after bowel manipula...
Modelos Animales de Enfermedad,
Ácido Etacrínico/farmacología,
Tránsito Gastrointestinal/efectos de los fármacos,
Ileus/patología,
Ileus/cirugía,
Mediadores de Inflamación/antagonistas & inhibidores,
Interleucina-6/antagonistas & inhibidores,
Intestino Delgado/efectos de los fármacos,
Intestino Delgado/patología,
Ratones Endogámicos C57BL,
Óxido Nítrico Sintasa de Tipo II/antagonistas & inhibidores,
Complicaciones Posoperatorias,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
