Abstract Efavirenz is one of the most commonly used drugs in HIV therapy. However the low water solubility tends to result in low bioavailability. Drug nanocrystals, should enhance the dissolution and consequently bioavailability. The aim of the present study was to obtain EFV nanocrystals prepared by an...
Nanopartículas/administración & dosificación,
Cristalización/instrumentación,
Disolución/métodos,
Eficacia/clasificación,
Excipientes/farmacología,
VIH/patogenicidad,
Métodos,
Preparaciones Farmacéuticas/administración & dosificación,
Solubilidad,
Tamaño de la Partícula,
Disolución/clasificación
Guimarães, Nathalia Sernizon;
Costa, Murilo Soares;
Machado, Elaine Leandro;
Sato, Hugo Itaru;
Amaral, Eduarda de Carvalho Maia e;
Arivabene, Rafaela Galvão;
Lourenço, Karine Lima;
Tupinambás, Unaí;
Fonseca, Flávio Guimarães da;
Takahashi, Ricardo Hiroshi Caldeira;
Teixeira, Santuza Maria Ribeiro;
Alves, Claudia Regina Lindgren.
Objetivo: Demonstrar a viabilidade da utilização combinada da autocoleta de swab nasofaríngeo e pool testing para detecção do SARS-CoV-2 em inquéritos epidemiológicos. Métodos: A experiência envolveu amostra de 154 estudantes da Universidade Federal de Minas Gerais, que realizaram a autocoleta ...
SARS-CoV-2 é um novo agente infeccioso e pouco se sabe acerca do risco de sua infecção
para o desenvolvimento embrionário e fetal humano, por isso é de extrema importância
identificar o quadro clínico da infecção em gestantes, bem como registrar as complicações
perinatais associadas à COVID-1...
Abstract Up to today, there is no specific treatment against SARS-CoV-2 / COVID-19 infection; there the necessity to search for alternatives that help patients with COVID-19. The objective of this study was to review the use of ozone therapy as adjunct treatment for SARS-CoV-2 / COVID-19 infection, highl...
Abstract The chemical hydroxymethylation of the antimicrobial nitrofurazone leads to the prodrug NFOH, also increases the anti-T. cruzi activities (in vitro and in vivo), as well as showed non-genotoxic (Ames and micronucleus assays). In the present study, we assessed the anti-T. cruzi effect of the NFOH...
Abstract Highly Active Antiretroviral therapy (HAART) depends on optimal adherence to be effective. Pharmacotherapeutic follow-up can be used as a strategy for treatment fidelity. To provide pharmaceutical care for HAART patients, to assess adherence, to identify and resolve drug related problems (DRP). ...
Abstract Candida glabrata infections are responsible for deaths of people globally. Fluconazole is known to be less effective against C. glabrata, which developed many strategies to evade being destroyed by fluconazole. To achieve enhanced efficacy of fluconazole against C. glabrata, the interaction of f...
Abstract Neonatal sepsis continues to be a major cause of morbidity and mortality worldwide. Coagulase-negative staphylococci (CoNS), commonly found on the skin, being the main agents isolated. The aim of this study was to evaluate CoNS isolated from blood cultures of newborn (NB) infants. The study took...
Recién Nacido,
Síndrome Estafilocócico de la Piel Escaldada/patología,
Coagulasa/efectos adversos,
Cultivo de Sangre/instrumentación,
Staphylococcus epidermidis/patogenicidad,
Cultivo de Sangre/clasificación,
Sepsis/patología,
Pruebas de Sensibilidad Microbiana/instrumentación,
Mortalidad,
Hospitales,
Piel
Abstract Objective: To assess the antibacterial activity of Psidium guajava fractions and their effects on adhesion of a multispecies biofilm consisting of Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis in vitro. Material and Methods: Guava leaves were obtained from the m...
Abstract The announcement by the WHO of the characterization of the new Coronavirus 2019 disease (COVID-19) as a pandemic, entails an adaptation by the community pharmacy in carrying out its care activity in general, with particular emphasis on "Minor Ailments Service" in particular. The measures taken b...
