Results: 360

Manual do Cremesp de melhores práticas clínicas na COVID-19

As informações vindas de outras nações já evidenciavam que, quando a covid-19 chegasse ao Brasil, grandes desafios seriam enfrentados. Como estratégia de resposta aos pares, o Cremesp deu início às aulas virtuais no assunto, em um momento em que as lives ainda nem estavam tão popularizadas, alé...

Hyperimmune globulin and monoclonal antibody for the treatment of SARS CoV-2 infection

Rev. patol. trop; 49 (4), 2020
The current pandemic of COVID-19 (Coronavirus Disease-19), caused by the pathogen SARSCoV-2, leading to thousands of deaths in 2020, has mobilized the scientific community, with the purpose of understanding the different aspects of the disease and proposing new treatment and prevention measures. Research...

Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools

Zika virus (ZIKV), an emerging arthropod-borne virus (arbovirus) of the Flaviviridae family, is a current issue worldwide, particularly because of the congenital and neurological syndromes associated with infection by this virus. As the initial clinical symptoms of all diseases caused by this group are v...

Uso de fármacos anticorpos monoclonais, imunomoduladores e anti-inflamatórios no tratamento da infecção por COVID-19

O objetivo deste estudo foi realizar o levantamento bibliográfico de artigos científicos e ensaios clínicos sobre a utilização de anticorpos monoclonais, imunomoduladores e anti-inflamatórios como possíveis alternativas terapêuticas para uso em pacientes com COVID-19, com ênfase nos mecanismos...

Precision Medicine, Artificial Intelligence, and Genomic Markers in Urology. Do we need to Tailor our Clinical Practice?

Precision medicine plays a key role in urological oncology practice nowadays, with the breakthrough of the poly (ADP-ribose) polymerase inhibitors (PARPi), which play a critical role in different DNA damage repair (DDR) pathways, the immune checkpoint inhibitors, the genomic expression profiles and curre...

Although with intact mucosa at colonoscopy, chagasic megacolons have an overexpression of Gal-3

ABSTRACT Objective To evaluate the density of anti-galectin-3-immunostained cells, collagen percentage, mast cell density and presence of pathological processes in intestinal muscle biopsies of patients. Methods Thirty-five patients who underwent intestinal biopsy were selected from 1997 to 2015. Patie...

Atypical hemolytic-uremic syndrome (aHUS)

Acta méd. colomb; 44 (4), 2019
Abstract Atypical hemolytic-uremic syndrome (aHUS) is a diagnosis of exclusion which should be proposed in cases where there is microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It is associated with mutations which cause dysregulation of the complement system and implies an ad...

Efectos adversos inmunomediados por inhibidores de PD-1
PD-1 inhibitors immune-mediated side effects

Los anticuerpos monoclonales que inhiben los puntos de control PD-1 y CTLA-4 se usan actualmente en el tratamiento del melanoma y cáncer metastásico de pulmón de células no pequeñas, entre otros. Se refiere el caso de una paciente con cáncer de pulmón en tratamiento con pembrolizumab. La paciente ...