Results: 105

Chemical constituents and pharmacological profile of Gunnera manicata L. extracts

Braz. j. pharm. sci; 50 (1), 2014
Gunnera perpensa L. (Gunneraceae) is a native South African plant widely used in traditional medicine as an antibacterial and antifungal. In southern Brazil there is the native species called Gunnera manicata L. that also belongs to the Gunneraceae. Nevertheless, there is no information about chemical an...

Alginate-pomegranate peels' polyphenols beads: effects of formulation parameters on loading efficiency

Braz. j. pharm. sci; 50 (4), 2014
Calcium alginate beads containing pomegranate peels' polyphenol extract were encapsulated by ionic gelation method. The effects of various formulation factors (sodium alginate concentration, calcium chloride concentration, calcium chloride exposure time, gelling bath time maintaining, and extract concent...

Comparison of the antioxidant potential of antiparkinsonian drugs in different in vitro models

Braz. j. pharm. sci; 50 (4), 2014
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Furthermore, oxidative stress plays a role in PD, causing or contributing to the neurodegenerative process. Currently PD has only symptomatic treatment and still nothing ca...

Effect of chlorocholine chlorid on phenolic acids accumulation and polyphenols formation of buckwheat plants

Biol. Res; 47 (), 2014
BACKGROUND: Effect of chlorocholine chloride (CCC) on phenolic acids composition and polyphenols accumulation in various anatomical parts (stems, leaves and inflorescences) of common buckwheat (Fagopyrum esculentum Moench) in the early stages of vegetation period were surveyed. RESULTS: Treatment of buck...

Morphometric and phytochemical characterization of chaura fruits (Gaultheria pumila): a native Chilean berry with commercial potential

Biol. Res; 47 (), 2014
BACKGROUND: For the first time, a morphometric characterization of chaura (Gaultheria pumila) fruits has been conducted between natural populations growing in the Villarrica National Park, Araucania Region, Chile. Chaura is a native Ericaceae from Chile that produces aromatic and tasty fruits which could...

Investigations of anticholinestrase and antioxidant potentials of methanolic extract, subsequent fractions, crude saponins and flavonoids isolated from Isodon rugosus

Biol. Res; 47 (), 2014
BACKGROUND: Based on the ethnomedicinal uses and the effective outcomes of natural products in various diseases, this study was designed to evaluate Isodon rugosus as possible remedy in oxidative stress, alzheimer's and other neurodegenerative diseases. Acetylecholinestrase (AChE) and butyrylcholinestera...

Características químicas e nutricionais de arroz-preto, vermelho e selvagem e comparação por análise estatística multivariada

O arroz (Oryza sativa L.) é consumido predominantemente na forma polida, porém há uma tendência na procura por grãos integrais não pigmentados e pigmentados, como o preto e o vermelho, e também pelo arroz selvagem, que pertence ao gênero Zizania. Além da composição nutricional e propriedades s...

Caracterização e biodisponibilidade de derivados de ácido elágico da jabuticaba (Myrciaria jaboticaba)

O ácido elágico é um composto fenólico presente em algumas frutas e sementes. As maiores fontes da dieta humana são as frutas conhecidas como berries, a romã e as nozes. Dentre as frutas nativas brasileira, a jabuticaba apresenta teores de ácido elágico comparáveis aos das berries. Além disso, ...

Rational use of antioxidants in solid oral pharmaceutical preparations

Braz. j. pharm. sci; 48 (3), 2012
Antioxidants are currently used as efficient excipients that delay or inhibit the oxidation process of molecules. Excipients are often associated with adverse reactions. Stability studies can guide the search for solutions that minimize or delay the processes of degradation. The ability to predict oxidat...

Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats

Braz. j. pharm. sci; 47 (4), 2011
Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 mont...