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Results: 93

Analysis of the p53 gene by PCR-SSCP in ten cases of WilmsÆ tumor

Defavery, Ricardo; Lemos, José Alexandre Rodrigues; Kashima, Simone; Bernardes, José Eduardo; Scridelli, Carlos Alberto; Covas, Dimas Tadeu; Tone, Luiz Gonzaga.
Säo Paulo med. j; 118 (2), 2000
CONTEXT: Mutations of the p53 tumor suppressor gene are the most frequent alterations observed in human neoplasias affecting adults. In pediatric oncology, however, they have seldom been identified. WilmsÆ tumor is a renal neoplasia commonly occurring in children and is associated with mutations of the ...
Mutación/genética, Neoplasias Renales/genética, Tumor de Wilms/genética, Genes p53/genética, Reacción en Cadena de la Polimerasa/métodos, Polimorfismo Conformacional Retorcido-Simple, Análisis de Secuencia de ADN
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Genetic alterations in Ki-ras and Ha-ras genes in juvenile nasopharyngeal angiofibromas and head and neck cancer

Coutinho, Cláudia Malheiros; Bassini, Alessandra Simöes; Gutiérrez, Leonardo Guilhermino; Butugan, Ossamu; Kowalski, Luiz Paulo; Brentani, Maria Mitzi; Nagai, Maria Aparecida.
Säo Paulo med. j; 117 (3), 1999
Context: Ras gene mutations have been associated to a wide range of human solid tumors. Members of the ras gene family (Ki-ras, Ha-ras and N-ras) are structurally related and code for a protein (p21) known to play an important role in the regulation of normal signal transduction and cell growth. The freq...
Codón/genética, Mutación/genética, Carcinoma de Células Escamosas/genética, Neoplasias Nasofaríngeas/genética, Neoplasias de Cabeza y Cuello/genética, Angiofibroma/genética, Genes ras, Reacción en Cadena de la Polimerasa, Polimorfismo Conformacional Retorcido-Simple, Northern Blotting, Anciano de 80 o más Años, ADN de Neoplasias/genética, ARN Neoplásico, Secuencia de Bases
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