A series of N-(benzoylphenyl)-carboxamide derivatives (2a, 2b, 3a, 3b, 4a, 4b, 5a, 5b, 6a and 6b) was prepared with good yields by reacting the corresponding carbonyl chlorides with aminobenzophenones at room temperature. This was followed by evaluating the hypotriglyceridemic and hypocholesterolemic eff...
Hipolipemiantes/síntesis química,
Hipolipemiantes/farmacología,
Hiperlipidemias/inducido químicamente,
Lipoproteínas HDL/efectos de los fármacos,
Lipoproteínas LDL/efectos de los fármacos,
Modelos Animales de Enfermedad,
Ratas Wistar,
Piridinas/síntesis química,
Piridinas/farmacología,
Triglicéridos/sangre,
Colesterol/sangre,
Lípidos/sangre,
Polietilenglicoles
Abstract Exopolysaccharides (EPS) produced by Klebsiella oxytoca are of environmental, pharmaceutical, and medicinal interest. However, studies about the anti-inflammatory activity of EPS produced by this microorganism still remain limited. The aim of this study was to produce, characterize, and evaluate...
Abstract Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat metabol...
ABSTRACT: Objctive: Fructose consumption has increased worldwide. Excessive fructose intake has been a risk factor for the increased metabolic syndrome disorder incidence. This study aimed to investigate the possible influence of two different exercise training methods, continuous and interval, on fruct...
Abstract Objective: to investigate the effect of using different agents (topical hyaluronidase, photobiomodulation, and the association of photobiomodulation with topical hyaluronidase) in preventing the formation of lesions caused by doxorubicin extravasation, as well as in the reduction of lesions fo...
La periodontitis es una patología inflamatoria que aumenta la resorción de hueso alveolar (HA), pérdida de la inserción dentaria y posible exfoliación. Evaluamos el efecto de la administración intermitente de bajas dosis de parathormona (PTH) 1-34 sobre la recuperación de la mas...
Yildirim, Yasar;
Bahadir, Veysi;
Aydin, Emre;
Aydin, Fatma Yilmaz;
Yilmaz, Zülfükar;
Ketani, Aydin;
Kaplan, Ibrahim;
Tuncer, Mehmet Cudi;
Kadiroglu, Ali Kemal;
Yilmaz, Mehmet Emin.
SUMMARY: N-Acetylcysteine (NAC) is used for contrast induced acut kidney injury (CI-AKI) prophylaxis because of its antioxidant effects. Paricalcitol, which has reno-protective effects, is likely to provide a more effective prophylaxis when added to NAC treatment. The study was designed based on this hyp...
Lesión Renal Aguda/prevención & control,
Lesión Renal Aguda/inducido químicamente,
Medios de Contraste/efectos adversos,
Ergocalciferoles/administración & dosificación,
Ergocalciferoles/farmacología,
Acetilcisteína/administración & dosificación,
Acetilcisteína/farmacología,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar
SUMMARY: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent a unique class of glucose-declining renal-targeted drugs. The SGLT2i Canagliflozin (CANA) is an anti-hyperglycemic drug that reduces various cardiovascular and renal outcomes in patients with type 2 diabetes mellitus. This study aimed ...
SUMMARY: The objective of the study was to provide a detailed anatomical description of the rat's ear anatomy that will prove insightful to different experimental otologic surgical procedures regardless of scope. Three male Wistar rats were enrolled in the study. Candidates were screened for systemic and...
SUMMARY: Ischemia-reperfusion (I/R) of the small intestine causes serious abdominal pathologies including tissue dysfunction and organ failure. L-carnitine (L-C), a powerful antioxidant, may help lessen the severity of these pathological effects since it plays a key role in energy metabolism. In this wor...
