SUMMARY: Rheumatoid arthritis (RA), an inflammatory autoimmune disease that causes cartilage degradation and tissue destruction, can affect synovial joints such as the knee joint. The link between the nitrosative stress enzyme inducible nitric oxide synthase (iNOS) and the cytokine interleukin-1 (IL-1 ...
Artritis Reumatoide/inmunología,
Glucógeno Sintasa Quinasa 3 beta/antagonistas & inhibidores,
Tiadiazoles/administración & dosificación,
Glucógeno Sintasa Quinasa 3 beta/administración & dosificación,
Estrés Nitrosativo/efectos de los fármacos,
Interleucina-1beta,
Colágeno Tipo II/administración & dosificación,
Ratas Wistar,
Artritis Reumatoide/inducido químicamente,
Inmunohistoquímica,
Modelos Animales de Enfermedad,
Inflamación
Cardiovascular disease(CVD) remains the major cause of mortality in the world, typically claiming a third of all deaths. The primary cause of CVD is atherosclerosis. Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manif...
Aterosclerosis/dietoterapia,
Dieta Aterogénica/métodos,
Aceite de Oliva/farmacología,
Colesterol/farmacología,
Dieta Alta en Grasa/métodos,
Estrés Oxidativo/inmunología,
Glutatión/farmacología,
Peroxidación de Lípido/inmunología,
Triglicéridos/farmacología,
Hipercolesterolemia/inmunología,
Lipoproteínas/inmunología,
Ratas Wistar/inmunología
Background: Diabetes mellitus treatment is based on oral hypoglycemic agents or insulin. Medicinal plants constitute an option, and the leaves of Prosopis ruscifolia (Pr) were shown to be effective in reducing glycemia in hyperglycemic animals. Objective: In this paper, we report the effect of P. ru...
ABSTRACT Background: Epilepsy has neuropsychiatric comorbidities such as depression, bipolar disorder, and anxiety. Drugs that target epilepsy may also be useful for its neuropsychiatric comorbidities. Objective: To investigate the effects of serotonergic modulation on pro-inflammatory cytokines and th...
Anticonvulsivantes/efectos adversos,
Epilepsia/tratamiento farmacológico,
Fluoxetina/efectos adversos,
Interleucina-6,
Pentilenotetrazol/efectos adversos,
Ratas Wistar,
Convulsiones/inducido químicamente,
Convulsiones/tratamiento farmacológico,
Serotonina/efectos adversos,
Sumatriptán/efectos adversos,
Factor de Necrosis Tumoral alfa
Introduction: some plants such as turmeric, cinnamon, and okra are known to have therapeutic functions such as antioxidant and anti-inflammatory activity. Furthermore, an immunomodulatory role has been observed in the production of antibodies, in particular immunoglobulin A (IgA), which mediates a variet...
Abelmoschus,
Curcuma,
Anticuerpos,
Cinnamomum zeylanicum,
Formación de Anticuerpos,
Hígado,
Riñón,
Bazo,
Plantas,
Ratas Wistar,
Timo
O propósito do presente estudo foi avaliar a influência da Coenzima Q10 (CoQ10) no reparo periimplantar em implantes instalados em tíbias de ratos modificados sistemicamente ou não pela nicotina. Oitenta ratos machos (Wistar), foram divididos em quatro grupos (n=20). No dia 0 os animais receberam um ...
Santos, L S;
Matos, R J B;
Cordeiro, G S;
Perez, G S;
Santo, D A E;
Silva, R T;
Gonçalves, M S;
Boaventura, G T;
Deiró, T C B J;
Barreto-Medeiros, J M.
Exposure to the hight-fat diet may alter the control of food intake promoting hyperphagia and obesity. The objective of this study was to investigate the effects of this diet on dopamine receptors (drd1 and drd2), proopiomelanocortin (pomc), neuropeptideY (npy) genes expression, and preference food in ad...
Purpose:
To describe the technique of sublay correction of incisional hernia in Wistar rats under videomagnification system.
Methods:
Five male rats of the species Rattus norvegicus, of the Wistar lineage, with body weight between 250–350 g and 60 days old were used. Incisional hernia was inducted in ...
Purpose:
To evaluate the caliber of an arterial micro-anastomosis in the young growing animal using a continuous suture technique. Additionally, late morphological changes and blood flows distal to the anastomosis were evaluated.
Methods:
Seventy-four Wistar rats were submitted to laparotomy to access t...
Carvalho, Carolyna de Sousa;
Bernardes, Milton Junio Cândido;
Gonçalves, Randys Caldeira;
Vilela, Marielle Sousa;
Silva, Marcus Vinicius Meneses da;
Oliveira, Vinicius da Silva;
Rocha, Marcelo Ribeiro da;
Vinaud, Marina Clare;
Galdino Junior, Hélio;
Lino Junior, Ruy de Souza.
Purpose:
To evaluate the morphometric, macroscopic and microscopic aspects of experimentally induced partial-thickness burns in rats treated with different silver-based dressings.
Methods:
Wistar rats were used, divided into six treatments: saline (NaCl 0.9%); silver sulfadiazine 1%; Silvercel; Mepilex ...
