Higher plants have provided various natural derived drugs used currently in western medicine. Tessaria absinthioides (Hook. & Arn.) DC, Asteraceae, is a native plant from South-America with reported ethnopharmacological and culinary uses. Despite recent scientific reports about plants properties, there i...
Antineoplásicos Fitogénicos/farmacología,
Antineoplásicos Fitogénicos/uso terapéutico,
Asteraceae/química,
Línea Celular Tumoral,
Neoplasias Colorrectales/tratamiento farmacológico,
Neoplasias Colorrectales/patología,
Modelos Animales de Enfermedad,
Fluorouracilo,
Ratones Endogámicos BALB C,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Ratas Sprague-Dawley,
Sales de Tetrazolio,
Pruebas de Toxicidad
BACKGROUND Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules du...
Quimiocina CXCL10/uso terapéutico,
Citocinas/inmunología,
Interferón gamma/análisis,
Interleucina-10/biosíntesis,
Interleucina-4/biosíntesis,
Leishmania infantum,
Leishmaniasis Visceral/tratamiento farmacológico,
Leishmaniasis Visceral/inmunología,
Leishmaniasis Visceral/parasitología,
Hígado/patología,
Macrófagos/efectos de los fármacos,
Ratones Endogámicos BALB C,
Tamaño de los Órganos/fisiología
O Câncer de cólon é um dos tipos mais comuns de câncer no mundo e a segunda principal causa de morte relacionada a esta doença em países desenvolvidos. Até 75% dos casos estão associados com a alimentação, indicando que uma pessoa pode reduzir o seu risco simplesmente através de modificação ...
Abstract INTRODUCTION: The coral snake Micrurus surinamensis, which is widely distributed throughout Amazonia, has a neurotoxic venom. It is important to characterize the biological and molecular properties of this venom in order to develop effective antitoxins. METHODS: Toxins from the venom of M. s...
BALB/c mice were inoculated with 5-500 Toxocara canis infective eggs, and bled at 15-120 days post infection (dpi) to evaluate the dynamics of IgG antibody response and larvae distribution. Positive results were observed in all occasions for every inoculum, and a direct proportional relationship between ...
This study aimed to evaluate the characteristics of two different murine models of hormone-treated renal-encapsulated bovine ovarian tissue xenotransplantation. Two immunodeficient mouse models (BALB/c Nude and C57BL6 SCID) were xenografted with ovarian pieces from heifers and each group was subjected to...
Gasparotto, Juciano;
Kunzler, Alice;
Senger, Mario Roberto;
Souza, Celeste da Silva Freitas de;
Simone, Salvatore Giovanni de;
Bortolin, Rafael Calixto;
Somensi, Nauana;
Dal-Pizzol, Felipe;
Moreira, José Claudio Fonseca;
Abreu-Silva, Ana Lúcia;
Calabrese, Kátia da Silva;
Silva Jr, Floriano Paes;
Gelain, Daniel Pens.
BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. a...
BACKGROUND Bovine tuberculosis (TB) is a zoonotic disease caused by Mycobacterium bovis, responsible for causing major losses in livestock. A cost effective alternative to control the disease could be herd vaccination. The bacillus Calmette-Guérin (BCG) vaccine has a limited efficacy against bovine TB,...
Antígenos Bacterianos/inmunología,
Antígenos Bacterianos/metabolismo,
Vacuna BCG/genética,
Vacuna BCG/inmunología,
Escherichia coli/genética,
Vectores Genéticos,
Vectores Genéticos/inmunología,
Ratones Endogámicos BALB C,
Mycobacterium bovis/genética,
Mycobacterium bovis/inmunología,
Plásmidos/genética,
Plásmidos/inmunología
ABSTRACT Neurocysticercosis (NCC) is the most severe clinical manifestation of cysticercosis. One of the factors responsible for its symptomatology is the host inflammatory response. Therefore the influence of interleukin 4 (IL-4) on the induction of encephalitis in experimental NCC was evaluated. Metho...
Encéfalo/parasitología,
Cysticercus/fisiología,
Modelos Animales de Enfermedad,
Interacciones Huésped-Parásitos,
Encefalitis Infecciosa/sangre,
Encefalitis Infecciosa/parasitología,
Interleucina-4/sangre,
Ratones Endogámicos BALB C,
Neurocisticercosis/sangre,
Neurocisticercosis/parasitología,
Factores de Tiempo
Cardiomyocyte apoptosis plays key roles in the pathogenesis of heart diseases such as myocardial infarction. MicroRNAs are important regulators of gene expression, which are also involved in the regulation of cardiomyocyte apoptosis. However, cardiomyocyte apoptosis regulated by microRNA (miR)-122 is lar...
