Results: 148

Identificación in silico de moléculas potencialmente inhibidoras de CDK5, proteína relacionada con la enfermedad de Alzheimer
Identification in silico of potentially inhibitive molecules of CDK5, protein related with the Alzheimer´s disease

Introducción: La enfermedad de Alzheimer exhibe un compromiso neurodegenerativo e irreversible. Hoy, numerosas investigaciones promueven la inhibición de algunas quinasas para su tratamiento, de especial mención la CDK5. Objetivo: Identificación de nuevas moléculas con posibilidad de interactuar con...

Eficácia do treinamento com simulador cirúrgico Eyesi em melhorar a capsulorrexe em cápsulas de alta tensão

Rev. bras. oftalmol; 76 (2), 2017

The game as strategy for approach to sexuality with adolescents: theoretical-methodological ections

ABSTRACT Objective: To describe the Papo Reto [Straight Talk] game and reflect on its theoretical-methodological basis. Method: Analytical study on the process of elaboration of the Papo Reto online game, destined to adolescents aged 15-18 years, with access to the Game between 2014 and 2015. Results:...

Are there differences between comparison methods used to evaluate the accuracy and reliability of digital models?

ABSTRACT Objectives: The accuracy and reliability of plaster models and digital models acquired with two different surface laser scanners were tested by means of three methods: measurement with calipers, digital measurement with proper software and superimposition of the digital models. Methods: Thirt...

An agent-based simulation combined with group decision-making technique for improving the performance of an emergency department

Braz. j. med. biol. res; 50 (5), 2017
This study presents an agent-based simulation modeling in an emergency department. In a traditional approach, a supervisor (or a manager) allocates the resources (receptionist, nurses, doctors, etc.) to different sections based on personal experience or by using decision-support tools. In this study, eac...

Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents

Abstract In the study presented here, a new series of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives was targeted. The synthesis was initiated by the treatment of different secondary amines (1a-h) with 4-bromomethylbenzenesulfonyl chloride (2) to obtain various 1-{[4-(bro...

Identification of neprilysin as a potential target of arteannuin using computational drug repositioning

ABSTRACT The discovery of arteannuin (qinghaosu) in the 20th Century was a major advance for medicine. Besides functioning as a malaria therapy, arteannuin is a pharmacological agent in a range of other diseases, but its mechanism of action remains obscure. In this study, the reverse docking server Pharm...

In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer's disease

Background The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory. The subunit N-methyl D-aspartate receptor subtype 2B (NR2B) is the chie...

Mathematical modelling of vector-borne diseases and insecticide resistance evolution

Background: Vector-borne diseases are important public health issues and, consequently, in silico models that simulate them can be useful. The susceptible-infected-recovered (SIR) model simulates the population dynamics of an epidemic and can be easily adapted to vector-borne diseases, whereas the Hardy-...

Avaliação clínica de enfermagem na termoregulação do recém-nascido pré-termo: do desenvolvimento ao uso de tecnologia educacional digital

As tecnologias, fortemente representadas pelos serious games na atualidade, têm ressignificado o processo de ensino-aprendizagem em saúde e enfermagem, contribuindo para o ensino participativo e mediando a aprendizagem não só de estudantes, mas também de profissionais e pacientes. Este estudo consis...