Abstract INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. ...
BACKGROUND: Cisplatin resistance (DDP-resistance) remains one of the major causes of poor prognosis in females with ovarian cancer. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of cellular processes, including chemoresistance. The aim of this study was to explore the ro...
Cisplatino/farmacología,
Resistencia a Antineoplásicos/genética,
Neoplasias Ováricas/genética,
ARN Largo no Codificante/genética,
Apoptosis/efectos de los fármacos,
Proteína Potenciadora del Homólogo Zeste 2/antagonistas & inhibidores,
Regulación Neoplásica de la Expresión Génica/efectos de los fármacos,
Técnicas de Inactivación de Genes/métodos,
MicroARNs/antagonistas & inhibidores,
Sirtuina 1/antagonistas & inhibidores,
Línea Celular Tumoral,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Arriba
Muñoz-Villagrán, C;
Contreras, F;
Cornejo, F;
Figueroa, M;
Valenzuela-Bezanilla, D;
Luraschi, R;
Reinoso, C;
Rivas-Pardo, J;
Vásquez, C;
Castro, M;
Arenas, F.
BACKGROUND: There Is an emerging field to put Into practice new strategies for developing molecules with antimicrobial properties. In this line, several metals and metalloids are currently being used for these purposes, although their cellular effect(s) or target(s) in a particular organism are still unk...
Zhao, Xiaoying;
Zhang, Erfei;
Ren, Xiaofen;
Bai, Xiaoli;
Wang, Dongming;
Bai, Ling;
Luo, Danlei;
Guo, Zheng;
Wang, Qiang;
Yang, Jianxin.
BACKGROUND: Kidney ischemia-reperfusion injury is a common pathophysiological phenomenon in the clinic. A large number of studies have found that the tyrosine protein kinase/signal transducer and activator of transcription (JAK/STAT) pathway is involved in the development of a variety of kidney diseases ...
BACKGROUND: In modern societies, sleep deprivation is a serious health problem. This problem could be induced by a variety of reasons, including lifestyle habits or neurological disorders. Chronic sleep deprivation (CSD) could have complex biological consequences, such as changes in neural autonomic cont...
Guidez, Amandine;
Pocquet, Nicolas;
Restrepo, Johana;
Mathieu, Luana;
Gaborit, Pascal;
Issaly, Jean;
Carinci, Romuald;
Chandre, Fabrice;
Epelboin, Yanouk;
Romain, Girod;
Dusfour, Isabelle.
BACKGROUND Aedes aegypti is the sole vector of urban arboviruses in French Guiana. Overtime, the species has been responsible for the transmission of viruses during yellow fever, dengue, chikungunya and Zika outbreaks. Decades of vector control have produced resistant populations to deltamethrin, the sol...
Aedes/efectos de los fármacos,
Aedes/genética,
Guyana Francesa,
Insectos Vectores/efectos de los fármacos,
Insectos Vectores/genética,
Resistencia a los Insecticidas/efectos de los fármacos,
Resistencia a los Insecticidas/genética,
Insecticidas/farmacología,
Control de Mosquitos/métodos,
Mosquitos Vectores/efectos de los fármacos,
Mosquitos Vectores/virología,
Piretrinas/farmacología,
Análisis Espacio-Temporal
Guimarães, Arthur Emil dos Santos;
Sharma, Abhinav;
Furlaneto, Ismari Perini;
Rutaihwa, Liliana;
Cardoso, Jedson Ferreira;
da Conceição, Marília Lima;
Spinassé, Lizânia Borges;
Machado, Edson;
Lopes, Maria Luiza;
Duarte, Rafael Silva;
Gagneux, Sebastien;
Suffys, Philip Noel;
Lima, Karla Valéria Batista;
Conceição, Emilyn Costa.
BACKGROUND The evaluation of procedures for drug susceptibility prediction of Mycobacterium tuberculosis based on genomic data against the conventional reference method test based on culture is realistic considering the scenario of growing number of tools proposals based on whole-genome sequences (WGS)....
Antituberculosos/farmacología,
Antituberculosos/uso terapéutico,
Brasil,
Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos,
Farmacorresistencia Bacteriana Múltiple/genética,
Pruebas de Sensibilidad Microbiana,
Mycobacterium tuberculosis/efectos de los fármacos,
Mycobacterium tuberculosis/genética,
Mycobacterium tuberculosis/aislamiento & purificación,
Preparaciones Farmacéuticas,
Tuberculosis Resistente a Múltiples Medicamentos/tratamiento farmacológico,
Tuberculosis Resistente a Múltiples Medicamentos/genética,
Secuenciación Completa del Genoma
Abstract INTRODUCTION: Pseudomonas aeruginosa is an opportunistic pathogen associated with healthcare-related infections, affecting mainly patients with underlying diseases and immunosuppression. This microorganism has several virulence mechanisms that favour its pathogenesis, including the production o...
RESUMO. O objetivo deste artigo, de caráter teórico descritivo, foi analisar as principais motivações para o aprimoramento cognitivo farmacológico na contemporaneidade, mediante o diálogo com autores que investigaram alguns fenômenos da denominada pós-modernidade, tais como Deleuze (1992), Foucau...
SUMMARY An alarming fact was revealed by recent publications concerning disinfectants: chlorhexidine digluconate is ineffective for disinfecting surfaces contaminated by the new coronavirus. This is a finding that requires immediate disclosure since this substance is widely used for the disinfection of h...
