Abstract Background: Impaired angiogenesis in cardiac tissue is a major complication of diabetes. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play important role during capillary-like network formation in angiogenesis process. Objectives: To determine the e...
Andrógenos/farmacología,
Andrógenos/uso terapéutico,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/fisiopatología,
Diabetes Mellitus Tipo 1/metabolismo,
Diabetes Mellitus Tipo 1/fisiopatología,
Ensayo de Inmunoadsorción Enzimática,
Quinasas MAP Reguladas por Señal Extracelular/análisis,
Quinasas MAP Reguladas por Señal Extracelular/efectos de los fármacos,
Quinasas MAP Reguladas por Señal Extracelular/metabolismo,
Corazón/efectos de los fármacos,
Corazón/fisiopatología,
Terapia de Reemplazo de Hormonas/métodos,
Miocardio/química,
Condicionamiento Físico Animal/fisiología,
Testosterona/farmacología,
Factores de Tiempo,
Ratas Wistar,
Reproducibilidad de los Resultados,
Transducción de Señal/efectos de los fármacos
Abstract Objective: To determine whether intraperitoneal silymarin administration has favorable effects on the heart, lungs, kidney, and liver and on oxidative stress in a rat model of supraceliac aorta ischemia/reperfusion injury. Methods: Thirty male Wistar albino rats were divided equally into three...
Abstract Background and objectives: To evaluate the thermographic predictive value of local anesthetic poisoning in rats that indicates the early recognition of thermal signs of intoxication and enable the immediate start of advanced life support. Methods: Wistar rats underwent intraperitoneal injectio...
ABSTRACT Background The inherent complications of cirrhosis include protein-calorie malnutrition and micronutrient deficiencies.Changes in taste are detrimental to the nutritional status, and the mechanism to explain these changes is not well documented in the cirrhotic patients. Objective To evaluate ...
ABSTRACT PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy´s criteria evaluation. METHODS: Sixty-one Wistar female rats were distributed into three grou...
ABSTRACT PURPOSE: To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS: Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosi...
Focos de Criptas Aberrantes/patología,
Carcinogénesis,
Colon Sigmoide/cirugía,
Neoplasias Intestinales/etiología,
Lisina/farmacología,
Estomas Quirúrgicos,
Modelos Animales de Enfermedad,
Mucosa Intestinal/patología,
Ratas Wistar,
Estomas Quirúrgicos/efectos adversos,
Ureterostomía/métodos,
Neoplasias de la Vejiga Urinaria/etiología
Silva, Eduardo Nascimento;
Ribas-Filho, Jurandir Marcondes;
Czeczko, Nicolau Gregori;
Pachnicki, Jan Pawel Andrade;
Netto, Mário Rodrigues Montemor;
Lipinski, Leandro Cavalcante;
Noronha, Lucia de;
Colman, Joelmir;
Zeni, João Otavio;
Carvalho, Caroline Aragão de.
ABSTRACT PURPOSE: To assess the capsules formed by silicone implants coated with polyurethane foam and with a textured surface. METHODS: Sixty-four Wistar albinus rats were divided into two groups of 32 each using polyurethane foam and textured surface. The capsules around the implants were analyzed f...
Implantes de Mama/efectos adversos,
Materiales Biocompatibles Revestidos,
Reacción a Cuerpo Extraño/patología,
Contractura Capsular en Implantes/patología,
Poliuretanos/administración & dosificación,
Geles de Silicona/administración & dosificación,
Implantación de Mama/métodos,
Colágeno Tipo I/análisis,
Colágeno Tipo III/análisis,
Ratas Wistar,
Propiedades de Superficie
ABSTRACT PURPOSE: To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. METHODS: Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile du...
Antioxidantes/farmacología,
Ictericia Obstructiva/complicaciones,
Hígado/patología,
Estrés Oxidativo/efectos de los fármacos,
Silimarina/farmacología,
Conductos Biliares,
Glutatión/sangre,
Ictericia Obstructiva/patología,
Ligadura,
Malondialdehído/sangre,
Sustancias Protectoras/farmacología,
Distribución Aleatoria,
Ratas Wistar
ABSTRACT PURPOSE: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats. METHODS: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintaine...
Cocos/química,
Sepsis/tratamiento farmacológico,
Choque Hemorrágico/tratamiento farmacológico,
Simvastatina/administración & dosificación,
Agua,
Cacao,
Modelos Animales de Enfermedad,
Inhibidores de Hidroximetilglutaril-CoA Reductasas/administración & dosificación,
Riñón/efectos de los fármacos,
Hígado/efectos de los fármacos,
Pulmón/efectos de los fármacos,
Ratas Wistar,
Resucitación/métodos,
Cloruro de Sodio/administración & dosificación
Ohashi, Camila Melo;
Caldeira, Fabio Alves Morikawa;
Feitosa-Junior, Denilson José Silva;
Valente, André Lopes;
Dutra, Paulo Roberto Witter;
Miranda, Moysés dos Santos;
Santos, Simone do Socorro Damasceno;
Brito, Marcus Vinicius Henriques;
Ohashi, Otávio Mitio;
Yasojima, Edson Yuzur.
ABSTRACT PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were mad...
