BACKGROUND Since the World Health Organization (WHO) declared Coronavirus disease 2019 (COVID-19) to be a pandemic infection, important severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (nsp) have been analysed as promising targets in virtual screening approaches. Amon...
Betacoronavirus/efectos de los fármacos,
COVID-19,
Proteasas 3C de Coronavirus,
Infecciones por Coronavirus,
Cisteína Endopeptidasas,
Flavonoides/farmacología,
Glicósidos/farmacología,
Simulación del Acoplamiento Molecular,
Pandemias,
Neumonía Viral,
ARN Polimerasa Dependiente del ARN/antagonistas & inhibidores,
SARS-CoV-2,
Proteínas no Estructurales Virales/antagonistas & inhibidores
BACKGROUND Acinetobacter baumannii outbreaks have been associated with pandemic International Clones (ICs), but the virulence factors involved with their pathogenicity are sparsely understood. Pigment production has been linked with bacterial pathogenicity, however, this phenotype is rarely observed in A...
Infecciones por Acinetobacter/microbiología,
Acinetobacter baumannii/efectos de los fármacos,
Acinetobacter baumannii/genética,
Acinetobacter baumannii/aislamiento & purificación,
Antibacterianos/farmacología,
Vías Biosintéticas/genética,
Electroforesis en Gel de Campo Pulsado,
Melaninas,
Pruebas de Sensibilidad Microbiana,
Tipificación de Secuencias Multilocus,
Pandemias,
beta-Lactamasas
BACKGROUND Long lasting insecticide-treated nets (LLINs) may be effective for vector control of cutaneous leishmaniasis (CL). Their efficacy, however, has not been sufficiently evaluated. OBJECTIVE To evaluate the large-scale efficacy of LLINs on Lutzomyia longiflocosa entomological parameters up to t...
Anopheles/efectos de los fármacos,
Colombia,
Insectos Vectores/efectos de los fármacos,
Resistencia a los Insecticidas,
Mosquiteros Tratados con Insecticida,
Insecticidas/administración & dosificación,
Leishmaniasis Cutánea/parasitología,
Leishmaniasis Cutánea/prevención & control,
Control de Mosquitos/métodos,
Mosquitos Vectores,
Población Rural
BACKGROUND Oxidative stress is responsible for generating DNA lesions and the 8-oxoguanine (8-oxoG) is the most commonly lesion found in DNA damage. When this base is incorporated during DNA replication, it could generate double-strand DNA breaks and cellular death. MutT enzyme hydrolyzes the 8-oxoG fro...
Antimonio/toxicidad,
Antiprotozoarios/farmacología,
Proteínas de Escherichia coli/genética,
Proteínas de Escherichia coli/metabolismo,
Escherichia coli,
Guanina/análogos & derivados,
Guanina/farmacología,
Peróxido de Hidrógeno/toxicidad,
Leishmania braziliensis/efectos de los fármacos,
Leishmania braziliensis/enzimología,
Leishmania infantum/efectos de los fármacos,
Leishmania infantum/enzimología,
Estrés Oxidativo/efectos de los fármacos,
Estrés Oxidativo/fisiología,
Pirofosfatasas/genética,
Pirofosfatasas/metabolismo,
Conejos,
Superóxido Dismutasa/genética,
Superóxido Dismutasa/metabolismo
BACKGROUND Kaempferol (KPF) is a flavonoid with antiparasitic activity including experimental giardiasis which mechanism of action is unknown. OBJECTIVE To analyse the cytotoxic effects of KPF on Giardia duodenalis trophozoites and to identify a likely parasite target of this compound. METHODS We use...
BACKGROUND Metformin (MET) is a hypoglycemic drug used for the treatment of diabetes, despite interference in host immunity against microorganisms. Cutaneous infection caused by pathogens such as Leishmania braziliensis (Lb), the agent responsible for cutaneous leishmaniasis (CL) in Brazil, represents a...
Miranda, Silvana Spindola de;
Almeida, Isabela Neves de;
Mansur, Maria de Fátima Filardi Oliveira;
Figueredo, Lida Jouca de Assis;
Carvalho, Wânia da Silva;
Hadaad, João Paulo Amaral;
Diniz, Jaciara de Lourdes do Carmo Guimarães;
Groll, Andrea von;
Silva, Pedro Almeida da;
Lopes, Maria Luiza;
Santos, Marcelo Cordeiro dos;
Brito, Alexandra;
Mello, Fernanda Carvalho de Queiroz;
Malaquias, Thiago da Silva Santos;
Croda, Julio;
Pinhata, Juliana Maira Watanabe;
Oliveira, Rosângela Siqueira de;
Chimara, Erica;
Rossetti, Maria Lúcia;
Halon, Maria Laura;
Lourenço, Maria Cristina;
Medeiros, Reginalda Ferreira de Melo;
Montes, Fátima Cristina Onofre Fandinho;
Machado, Diana;
Viveiros, Miguel;
Kritski, Afrânio Lineu.
Abstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its...
Abstract Conventional orthodontic treatment with the use of stainless steel may be detrimental to oral health by promoting demineralizing lesions appearance and increasing adhesion and formation of bacterial biofilm, inducing the development of cavities. An alternative that has been researched to reduce ...
Alambres para Ortodoncia,
Antibacterianos/farmacología,
Plata,
Nanopartículas del Metal,
51661,
Microscopía Electrónica de Rastreo,
Calorimetría,
Adhesión Bacteriana,
Placa Dental,
Staphylococcus aureus/efectos de los fármacos,
Streptococcus mutans/efectos de los fármacos
Abstract In the current study, nanocapsules (NC) formulations containing a co-load of clotrimazole (C), a highly prescribed antifungal drug, and diphenyl diselenide [(PhSe)2], an organoselenium compound with a promising scope of pharmacological actions, were prepared. Formulations were characterized as w...
The objective of this study was to evaluate the effect of timbó seed coat on the physiological and sanitary quality of soybean seeds. Timbó seeds were collected from mature fruits in the Cerrado. The external layer of the seed coat was removed and crushed in a mill and used in the treatment of soybean ...
