ABSTRACT Diabetes is a life-threatening disease, and currently available synthetic medicines for treating diabetes are associated with various side effects. Therefore, there is an unmet need to develop herbal remedies against diabetes as an alternative to synthetic medicines. Although local healers use t...
Abstract Piper nigrum (black pepper) is used in Indian traditional medicine and its main alkaloid, Piperine (PIP), presents antioxidant, antitumor and neuroprotective pharmacological properties. This substance is insoluble in aqueous media and can irritate the gastrointestinal tract. Aiming to avoid thes...
Piper nigrum/efectos adversos,
Composición de Medicamentos/instrumentación,
d0002840,
Alcaloides/efectos adversos,
Antioxidantes/efectos adversos,
Análisis Espectral/métodos,
Comprimidos/clasificación,
Medicina Tradicional/instrumentación,
Microscopía Electrónica de Rastreo/métodos,
Tracto Gastrointestinal/anomalías,
Técnicas In Vitro/métodos
Abstract Hedera nepalensis (H. nepalensis) , belonging to the family Araliaceae, is a medicinal plant traditionally used to treat stomach problems. The current study investigated the gastroprotective potential and the mechanism of action of H. nepalensis in diclofenac-and ethanol-induced ulcer models. An...
Araliaceae/clasificación,
Plantas Medicinales,
Antioxidantes,
Diclofenaco/agonistas,
Úlcera/inducido químicamente,
Úlcera Gástrica/patología,
ddcs0515740,
Cromatografía Líquida de Alta Presión/métodos,
Espectroscopía Infrarroja por Transformada de Fourier/métodos,
Estómago/anomalías,
Hedera/clasificación
Abstract The present study was aimed at conducting phytochemical analysis and evaluating the in vitro antifungal and antioxidant activities of the essential oil obtained from the fruits of J. oxycedrus L. Hydro-distillation was used to extract the essential oil from the fruits of Juniper oxycedrus. The ...
Antioxidantes/farmacología,
Aceites Volátiles/análisis,
Juniperus/efectos adversos,
Marruecos/etnología,
Frutas/clasificación,
Antifúngicos/farmacología,
Fitoquímicos/análisis,
Cromatografía de Gases/métodos,
Espectrometría de Masas/métodos,
d0000772220,
Pruebas de Sensibilidad Microbiana/métodos,
Técnicas In Vitro/métodos
Abstract The locust bean gum (LBG) is a polysaccharide with thickening, stabilizing and gelling properties and it has been used in the preparation of pharmaceutical formulations. Hydrogels (HGs) are obtained from natural or synthetic materials that present interesting properties for skin application. Thi...
Abstract The present study entails the systematic development and validation of a stability-indicating RP-HPLC method for the analysis of sitagliptin and ertugliflozin in a fixed-dose combination. Analytical quality by design (AQbD) concepts were used to define critical method variables, employing Pareto...
Liu, Haiqiong;
Liang, Qian;
Mei, Xiheng;
Li, Hekai;
Yan, Jing;
Long, Man;
Yang, Xili;
Wang, Wei;
Li, Weijie;
Chen, Aihua;
Ling, Yuanna.
Abstract Compound Danshen Dripping Pills (CDDPs) have been used in clinical treatment to protect the heart from ischemia/reperfusion (IR) injury for many years. However, the underlying mechanism implicated in the protective effects remains to be explored. Here, we determined the effects of CDDPs in Sprag...
Ecocardiografía/métodos,
d0013430,
d0172090,
Isquemia/clasificación,
Reperfusión/clasificación,
Corazón/fisiopatología,
Infarto/patología,
Microscopía Electrónica de Transmisión/métodos,
d0275610,
Daño por Reperfusión/clasificación,
Western Blotting/instrumentación
Abstract Biological activity of boron-containing compounds (BCCs) has been well-known. Growing interest and numerous applications for BCCs have been reported. Boron and boron-containing acids show low acute toxicity in mammals but data on halogenated boroxine (HB) - dipotassium-trioxohydroxytetrafluorotr...
Desarrollo de Medicamentos/instrumentación,
Boro/agonistas,
Pruebas de Toxicidad Aguda/instrumentación,
Antioxidantes/farmacología,
d0099340,
Productos Biológicos/efectos adversos,
Técnicas In Vitro/métodos,
d0001430,
d0079280,
d0207140,
ddcs0516950
Abstract Donepezil-HCl is a member of the acetylcholinesterase inhibitors that is indicated for the symptomatic treatment of Alzheimer’s disease (AD) and has many side effects. In this study, to reduce the side effects of Donepezil-HCl and increase the penetration of the drug through the blood-brain ba...
Abstract Infusion solutions must be stable from the production stage until the infusion stage. Some infusion fluids contain degradation products, known as advanced glycation end products (AGEs); however, it is unknown whether AGEs exist in parenteral nutrition solutions. We aimed to investigate this ques...
