This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass co...
2,4-Dinitrofenol/farmacocinética,
Transportadoras de Casetes de Unión a ATP/antagonistas & inhibidores,
Adyuvantes Farmacéuticos/farmacología,
Cromatografía Líquida de Alta Presión/métodos,
Curcumina/análogos & derivados,
Curcumina/química,
Curcumina/farmacocinética,
Emulsiones,
Inhibidores Enzimáticos/farmacocinética,
Absorción Intestinal,
Absorción Intestinal/efectos de los fármacos,
Intestino Delgado/efectos de los fármacos,
Intestino Delgado/metabolismo,
Proteínas Asociadas a Resistencia a Múltiples Medicamentos/análisis,
Proteínas Asociadas a Resistencia a Múltiples Medicamentos/antagonistas & inhibidores,
Imagen de Perfusión/métodos,
Probenecid/farmacología,
Ratas Sprague-Dawley,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Desacopladores/farmacología,
Verapamilo/farmacología
ABSTRACT The Maillard reaction of hydrochlorothiazide (HCTZ) and lactose has been previously demonstrated in pharmaceutical formulations. In this study, the activation energy of - hydrohlorothiazide and lactose interaction in the liquid state was ascertained under basic and neutral conditions. Convention...
Introdução: os Staphylococcus aureus resistentes a meticilina (MRSA) estão envolvidos nas infecções nosocomiais, na comunidade, nos animais de companhia e nos animais para produção de alimentos, estando a desinfecção e a antissepsia entre os procedimentos adotados como medidas de controle. O fen...
ABSTRACT Objective To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae; T. diffusa), as well as its toxicity in astrocytes. Methods Chemical analyses of hydroethanolic extract from powdered aerial parts ofT. diffusa wer...
Antioxidantes/química,
Astrocitos/efectos de los fármacos,
Extractos Vegetales/química,
Turnera/química,
Astrocitos/química,
Muerte Celular/efectos de los fármacos,
Cromatografía Líquida de Alta Presión/métodos,
Flavonas/análisis,
Flavonas/toxicidad,
Extractos Vegetales/toxicidad,
Espectrometría de Masa por Ionización de Electrospray/métodos
Fungal hydrolysis of ellagitannins produces hexahydroxydiphenic acid, which is considered an intermediate molecule in ellagic acid release. Ellagic acid has important and desirable beneficial health properties. The aim of this work was to identify the effect of different sources of ellagitannins on the e...
Introducción: el diclofenaco sódico es un derivado del ácido fenilácetico y pertenece al grupo de los antinflamatorios no esteroideos con propiedades antinflamatorios, analgésicas y antipiréticas pronunciadas. En la Farmacopea de los Estados Unidos (USP 36, 2013) aparece reportado los métodos anal...
O metabolismo do triptofano (Trp) se dá pela via das quinureninas (QUIN), pela via serotoninérgica (SER) e pela via das aminas traço. A primeira gera QUIN e uma variedade de outros metabólitos secundários. Quando conduzida pela enzima indolamina 2,3 dioxigenase (IDO) contribui para os fenômenos de ...
Glioma/complicaciones,
Línea Celular,
Triptófano,
Enfermedades Metabólicas/prevención & control,
Métodos de Análisis de Laboratorio y de Campo/análisis,
Cromatografía Líquida de Alta Presión/métodos,
Indolamina-Pirrol 2,3,-Dioxigenasa,
Triptófano,
Neuronas Serotoninérgicas,
Neurotransmisores,
Proteínas de Transporte de Serotonina en la Membrana Plasmática,
Melatonina
ABSTRACT The present work describes the development of a new high performance liquid chromatographic (HPLC) method for the determination of Cefixime trihydrate under different stress conditons as specified by ICH. For the analysis, a Phenomenex (250 x 4.6 mm, 5 µm particle size) ODS column and a SPD 20 ...
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This stu...
Antiinflamatorios no Esteroideos/sangre,
Antiinflamatorios no Esteroideos/farmacocinética,
Cromatografía Líquida de Alta Presión/métodos,
Extracción Líquido-Líquido/métodos,
Naproxeno/sangre,
Naproxeno/farmacocinética,
Piroxicam/análogos & derivados,
Piroxicam/sangre,
Piroxicam/farmacocinética,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo
Sida tuberculata (Malvaceae) is a medicinal plant traditionally used in Brazil as an antimicrobial and anti-inflammatory agent. Here, we aimed to investigate the different extractive techniques on phytochemical parameters, as well as to evaluate the toxicity and antioxidant capacity of S. tuberculata ext...
Antioxidantes/química,
Antioxidantes/toxicidad,
Cromatografía Líquida de Alta Presión/métodos,
Simulación por Computador,
Ecdisterona/toxicidad,
Malvaceae/química,
Malvaceae/toxicidad,
Extractos Vegetales/química,
Extractos Vegetales/toxicidad,
Hojas de la Planta/química,
Raíces de Plantas/química,
Ratas Wistar,
Pruebas de Toxicidad
