PnPa11 and PnPa13 are synthetic peptides derived from Phoneutria nigriventer spider venom, which display antinociceptive and neuroprotective properties. In this work, we evaluated the safety of intravitreal use and the neuroprotective effect of these peptides. Methods: The cytotoxicity and the antiangio...
Dantas, L L S F R;
Fonseca, A G;
Pereira, J R;
Furtado, A A;
Gomes, P A T M;
Fernandes-Pedrosa, M F;
Leite, A C L;
Rêgo, M J B M;
Pitta, M G R;
Lemos, T M A M.
Several isatin derivatives have shown important biological activities, which have attracted interest from researchers. For this reason, the present study aimed to evaluate the anti-inflammatory and antinociceptive effects of the isatin derivative (Z)-2-(5-chloro-2-oxoindolin-3-ylidene)-N-phenyl-hydrazine...
Abstract Chronic inflammation is a common indication of several diseases, e.g. asthma, chronic obstructive pulmonary disease (COPD), atherosclerosis, etc. Benzimidazole derivatives are preferable compounds to design new analgesic and anti-inflammatory substances due to their unique biological features. W...
A patela é o maior osso sesamoide do corpo humano, posicionado longitudinalmente na fáscia do músculo quadríceps, entre os tendões quadríceps e patelar. A patela bipartida dolorosa, também conhecida como “sincrondose dolorosa”, é uma causa conhecida de dor no joelho anterior, é um diagnósti...
Abstract Objective: To describe and analyze the availability and factors related to the presence of analgesics and non-steroidal anti-inflammatory drugs in the Brazilian public primary healthcare system. Material and Methods: This was a cross-sectional study that evaluated 17,903 health units that part...
Dexketoprofen trometamol (DT) is an active S (+) enantiomer of ketoprofen, and a non-steroidal anti-inflammatory agent. DT has a short biological half-life and the dosing interval is quite short when there is a need to maintain the desirable effect for longer time periods. Consequently, a controlled rele...
The plant world represents an important source of potential therapeutic agents, but concomitant administration of herbal and conventional medications may result in interactions with subsequent beneficial or adverse effects. This study was designed to examine the analgesic effect of thyme tincture and thy...
ABSTRACT Objective: To establish the prevalence of delirium and its subsyndrome in intensive care and to associate it with the use of sedative and analgesia, severity and mortality. Method: Carried out in two intensive care units of adult patients, this is a quantitative and transversal study, with 157...
Analgésicos/efectos adversos,
Cuidados Críticos/estadística & datos numéricos,
Delirio/epidemiología,
Hipnóticos y Sedantes/efectos adversos,
Analgésicos/administración & dosificación,
Distribución de Chi-Cuadrado,
Clonidina/administración & dosificación,
Clonidina/efectos adversos,
Estudios Transversales,
Delirio/inducido químicamente,
Fentanilo/administración & dosificación,
Fentanilo/efectos adversos,
Hipnóticos y Sedantes/administración & dosificación,
Unidades de Cuidados Intensivos,
Midazolam/administración & dosificación,
Midazolam/efectos adversos,
Midazolam/uso terapéutico,
Prevalencia,
Propofol/administración & dosificación,
Propofol/efectos adversos
Psychotria fractistipula L.B.Sm, R.M. Klein & Delprete (Rubiaceae) is found in the existing Atlantic Forest in the South of Brazil, in the Paraná and Santa Catarina States. The members of Rubiaceae are characterized chemically by the presence of alkaloids, some pharmacological properties of which in...
BACKGROUND: The reported incidence of postoperative sore throat (POST) varies widely from 14.4 to 100% with maximum severity at 4th to 6th postoperative hour. Nonetheless, it has increasingly become a common clinical problem particularly in thyroid surgery. Although POST usually resolves spontaneously in...
