Hatakeyama, Daniela Miki;
Tasima, Lídia Jorge;
Bravo-Tobar, Cesar Adolfo;
Serino-Silva, Caroline;
Tashima, Alexandre Keiji;
Rodrigues, Caroline Fabri Bittencourt;
Aguiar, Weslei da Silva;
Galizio, Nathália da Costa;
Lima, Eduardo Oliveira Venancio de;
Kavazoi, Victor Koiti;
Gutierrez-Marín, Juan David;
Farias, Iasmim Baptista de;
SantAnna, Sávio Stefanini;
Grego, Kathleen Fernandes;
Morais-Zani, Karen de;
Tanaka-Azevedo, Anita Mitico.
Variability in snake venoms is a well-studied phenomenon. However, sex-based variation of Bothrops atrox snake venom using siblings is poorly investigated. Bothrops atrox is responsible for the majority of snakebite accidents in the Brazilian Amazon region. Differences in the venom composition of Bothrop...
Development of antibiotic resistance that leads to resurgence of bacterial infections poses a threat to disease-free existence for humankind and is a challenge for the welfare of the society at large. Despite research efforts directed towards treatment of pathogens, antibiotics within new improved classe...
Abstract This study seeks to understand biological cancer drug availability through registration and prices of the biological agents used for cancer therapy and authorized for sale in the last 5 years in Brazil, Colombia, and Mexico, comparing the data to those for the United States of America (USA) and ...
Snake venom phospholipases A2 (svPLA2) are biologically active toxins, capable of triggering and modulating a wide range of biological functions. Among the svPLA2s, crotoxin (CTX) has been in the spotlight of bioprospecting research due to its role in modulating immune response and hemostasis. In the pre...
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors. Ethanol extract of Antrodia cinnamomea (EEA) has been widely studied for its health benefits including anticancer effects. The purpose of this study was to assess the effects of EEA on HNSCC. Cell proliferation, tra...
Antrodia/química,
Apoptosis/efectos de los fármacos,
Productos Biológicos/farmacología,
Western Blotting,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Etanol/aislamiento & purificación,
Etanol/farmacología,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/patología,
Ratones Endogámicos BALB C,
Carcinoma de Células Escamosas de Cabeza y Cuello/tratamiento farmacológico,
Carcinoma de Células Escamosas de Cabeza y Cuello/patología,
Factores de Tiempo
Abstract Purpose: In laparoscopic incisional hernia repair, meshes with a tissue-separating barrier are positioned intraperitoneally. Despite this property, the close contact between mesh and viscera involves a risk of adhesion formation. Some natural products, such as red propolis (RP), could reduce th...
Dong, Wenzhu;
Chen, Hangping;
Wang, Lu;
Cao, Xiaoqian;
Bu, Xiawei;
Peng, Yan;
Dong, Aiqing;
Ying, Mengjiang;
Chen, Xu;
Zhang, Xin;
Yao, Li.
Given their relationship with metabolic syndrome and systematic inflammatory diseases, the pathogenesis of hypertension, hyperglycemia, and hyperlipidemia is closely related. To explore the common genes among these three conditions, spontaneous hypertensive rats (SHR), spontaneous diabetic Goto-Kakizaki ...
Morsch, André Luis Bittencourt;
Henrique, Lilian Rodrigues;
Silva, Denise Rossato;
Garziera, Giovana;
Xavier, Ricardo Machado;
Hax, Vanessa;
Ferreira, Manoela Fantinel;
Kohem, Charles Lubianca;
Mancuso, Aline Castello Branco;
Gasparin, Andrese Aline;
Brenol, Claiton Viegas;
Andrade, Nicole Pamplona Bueno de;
Menegat, Franciele de Almeida;
Viecceli, Daniela;
Bohn, Renata;
Palominos, Penélope Esther.
Introduction: Registries of spondyloarthritis (SpA) patients’ follow-up provided evidence that tumor necrosis factor inhibitors (TNFi) increase the incidence of active tuberculosis infection (TB). However, most of these registries are from low burden TB areas. Few studies evaluated the safety of biolog...
Antirreumáticos/efectos adversos,
Tuberculosis/epidemiología,
Tuberculosis/inducido químicamente,
Espondiloartritis/tratamiento farmacológico,
Incidencia,
Inhibidores del Factor de Necrosis Tumoral/efectos adversos,
Productos Biológicos/efectos adversos,
Tuberculosis Latente/tratamiento farmacológico,
Inhibidores del Factor de Necrosis Tumoral/uso terapéutico,
Antirreumáticos/uso terapéutico,
Artritis Psoriásica/tratamiento farmacológico,
Espondilitis Anquilosante/tratamiento farmacológico,
Productos Biológicos/uso terapéutico,
Enfermedades Endémicas,
Estudios Retrospectivos,
Estudios de Seguimiento
Abstract Natural products have emerged as a rich source of bioactive compounds for adjunctive treatments of many infectious and inflammatory conditions, including periodontitis. Among the monoterpenes with significant biological properties, there is the perillyl alcohol (POH), which can be found in sever...
Antibacterianos/farmacología,
Arginasa/análisis,
Productos Biológicos/farmacología,
Proliferación Celular/efectos de los fármacos,
Citometría de Flujo,
Fusobacterium nucleatum/efectos de los fármacos,
Fusobacterium nucleatum/crecimiento & desarrollo,
Expresión Génica,
Lipopolisacáridos/farmacología,
Macrófagos/efectos de los fármacos,
Macrófagos/metabolismo,
Pruebas de Sensibilidad Microbiana,
Monoterpenos/farmacología,
Porphyromonas/efectos de los fármacos,
Porphyromonas/crecimiento & desarrollo,
Células RAW 264.7,
Especies Reactivas de Oxígeno/análisis,
Especies Reactivas de Oxígeno/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/análisis
Las terapias biológicas son una herramienta terapéutica fundamental en cierto grupo de pacientes, sin embargo, su seguridad en el embarazo y lactancia no está aún dilucidada. El objetivo de esta revisión es actualizar los conocimientos y recomendaciones respecto al uso de fármacos b...
