Abstract Background: Organoid cultures are primary cultures that maintain architectural characteristics and the relationships between cells, as well as the extracellular matrix. They are alternatives for pathophysiological or therapeutic investigation rather than animal and in vitro tests. Objective: D...
Biopsia,
Técnicas de Cultivo de Célula/normas,
Células Cultivadas,
Expresión Génica,
Luz,
Melaninas/biosíntesis,
Melaninas/efectos de la radiación,
Organoides/efectos de la radiación,
Dosis de Radiación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reproducibilidad de los Resultados,
Nitrato de Plata,
Pigmentación de la Piel/efectos de la radiación,
Factores de Tiempo,
Rayos Ultravioleta
The genus Mycoplasma includes more than 200 bacterial species that cause disease in animals. It is responsible for causing mastitis in bovines and may be related to other manifestations, such as arthritis and pneumonia in calves and heifers. The present study aimed to detect Mycoplasma bovis isolated fro...
Total Panax notoginseng saponin (TPNS) is the main bioactivity compound derived from the roots and rhizomes of Panax notoginseng (Burk.) F.H. Chen. The aim of this study was to investigate the effectiveness of TPNS in treating vascular neointimal hyperplasia in rats and its mechanisms. Male Sprague-Dawle...
Traumatismos de las Arterias Carótidas/etiología,
Traumatismos de las Arterias Carótidas/prevención & control,
Hiperplasia,
Inmunohistoquímica,
Neointima/patología,
Panax notoginseng/efectos de los fármacos,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Saponinas/farmacología,
Transducción de Señal,
Regulación hacia Arriba,
Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo
This study aimed to investigate the therapeutic effect of fasudil on treating experimental autoimmune neuritis (EAN). Twenty-four EAN mice were randomly assigned to fasudil treatment (Fasudil group) or saline treatment (EAN model group) for 28 days. Clinical symptom score was evaluated every other day; i...
Interferón gamma/sangre,
Interleucinas/sangre,
Ratones Endogámicos C57BL,
Neuritis Autoinmune Experimental/sangre,
Neuritis Autoinmune Experimental/tratamiento farmacológico,
ARN Mitocondrial,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Nervio Ciático/efectos de los fármacos,
Nervio Ciático/metabolismo,
Linfocitos T Colaboradores-Inductores/efectos de los fármacos,
Factores de Tiempo
This work investigated the occurrence of Perkinsus sp. in clam Anomalocardia brasiliana, oyster Crassostrea sp. and mussel Mytella falcata from the Jaguaribe River estuary, northeastern Brazil. The collection of clam (N = 300), oysters (N = 300) and mussels (N = 300) were...
Reperfusion strategies in acute myocardial infarction (AMI) can cause a series of additional clinical damage, defined as myocardial ischemia/reperfusion (I/R) injury, and thus there is a need for effective therapeutic methods to attenuate I/R injury. miR-26a-5p has been proven to be an essential regulato...
Western Blotting,
Modelos Animales de Enfermedad,
Citometría de Flujo,
Ratones Endogámicos C57BL,
MicroARNs/metabolismo,
Isquemia Miocárdica/metabolismo,
Daño por Reperfusión Miocárdica/metabolismo,
Miocitos Cardíacos/patología,
Fosfohidrolasa PTEN/metabolismo,
Fosfatidilinositol 3-Quinasas/metabolismo,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal
The objective of this study was to explore the role of the SULF2-mediated ERK/AKT signaling pathway in cervical cancer. SULF2 expression was detected in tumor tissues and tumor-adjacent normal tissues from cervical cancer patients. HeLa cells were divided into six groups: control group, NC group, SULF2 s...
Apoptosis,
Estudios de Casos y Controles,
Línea Celular Tumoral,
Regulación Neoplásica de la Expresión Génica,
Células HeLa,
Inmunohistoquímica,
Sistema de Señalización de MAP Quinasas/genética,
Sistema de Señalización de MAP Quinasas/fisiología,
Ratones Desnudos,
Estadificación de Neoplasias,
Proteínas Proto-Oncogénicas c-akt/genética,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Transducción de Señal,
Sulfatasas/genética,
Sulfatasas/metabolismo,
Neoplasias del Cuello Uterino/metabolismo
Abstract Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as ...
Análisis de Varianza,
Biomarcadores de Tumor/análisis,
Estudios de Casos y Controles,
Leucoplasia Bucal/patología,
Liquen Plano Oral/patología,
Modelos Lineales,
MicroARNs/análisis,
Neoplasias de la Boca/química,
Neoplasias de la Boca/patología,
Fibrosis de la Submucosa Bucal/patología,
Lesiones Precancerosas/patología,
Curva ROC,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Saliva/química,
Índice de Severidad de la Enfermedad
Arid, Juliana;
Antunes, Lívia Azeredo Alves;
Koch, Luiza Foltran de Azevedo;
Evangelista, Silvane Silva;
Vasconcelos, Katia Regina Felizardo;
Brancher, João Armando;
Gabardo, Marilisa Carneiro Leão;
Milani, Ana Julia;
Dutra, André Luiz Tannus;
Antunes, Leonardo Santos;
Vieira, Alexandre Rezende;
Feltrin-Souza, Juliana;
KÜchler, Erika Calvano.
Abstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescent...
Brasil/epidemiología,
Índice CPO,
Caries Dental/epidemiología,
Caries Dental/genética,
Estado Nutricional/genética,
Polimorfismo Genético,
Prevalencia,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Receptores Acoplados a Proteínas G/genética,
Análisis de Regresión,
Factores de Riesgo,
Encuestas y Cuestionarios,
Gusto/genética
O Citomegalovírus humano (HCMV) pertence à família Herpesviridae é a causa mais frequente de infecção congênita, ocorrendo em todas as regiões do mundo variando de 0,7% a 6,1%. Uma característica desse vírus é a sua capacidade de permanecer latente após uma infecção onde o vírus não é el...
