A Doença de Huntington (Huntington's disease - HD) trata-se de uma patologia neurodegenerativa hereditária caracteriza por meio da expressão das proteínas huntingtinas mutantes (mHtt), das mortes dos neurônios espinhais médios (medium spiny neurons MSNs) GABAérgicos D2-positivos do striatum e da h...
Abstract The objective of the present investigation was to design, optimize and characterize the gastro retentive floating levofloxacin tablets and perform in-vivo evaluation using radiographic imaging. The floating tablets were prepared by using polymers i.e hydroxy propyl methyl cellulose (HPMC-K4M) an...
Abstract To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@R...
Curcumina/análisis,
Citrus sinensis/clasificación,
Concentración de Iones de Hidrógeno,
Color,
Difracción de Rayos X/instrumentación,
Espectroscopía Infrarroja por Transformada de Fourier,
Evaporación/clasificación,
Métodos,
Polímeros,
Solventes/administración & dosificación,
Técnicas In Vitro/métodos,
Rastreo Diferencial de Calorimetría/métodos
Abstract Risperidone is an atypical antipsychotic drug widely prescribed all over the world due to its clinical advantages. The currently available long acting marketed depot formulation of risperidone is a microsphere based preparation using poly-[lactide-co-glycolide] (PLGA) as drug release barrier. It...
Abstract Traditionally dates is consumed as a rich source of iron supplement and the current research discuss the synthesis of silver nanoparticles (AgNPs) using methanolic seed extract of Rothan date and its application over in vitro anti-arthritic, anti-inflammatory and antiproliferative activity again...
Phoeniceae/efectos adversos,
Concentración 50 Inhibidora,
Dosificación/métodos,
Espectroscopía Infrarroja por Transformada de Fourier,
Nanopartículas,
Neoplasias Pulmonares/clasificación,
Potencial zeta,
Técnicas In Vitro/métodos,
Semillas,
Cronología como Asunto,
Plata
Abstract Periodontitis is an oral disease associated with inflammation and pain with swollen and bleeding gums. In the present study, dental pastes containing NSAIDs, namely, diclofenac sodium and nimesulide (1 % w/w) were prepared to treat periodontitis. Dental pastes of diclofenac sodium and nimesulide...
Pastas de Dientes/análisis,
Diclofenaco/efectos adversos,
Antiinflamatorios no Esteroideos/análisis,
Boca,
Enfermedad/clasificación,
Espectroscopía Infrarroja por Transformada de Fourier,
Encía/anomalías,
Inflamación/complicaciones,
Liberación de Fármacos,
Mucosa Bucal/anomalías,
Periodontitis,
Preparaciones Farmacéuticas,
Técnicas In Vitro/métodos
Objetivo: Poco se sabe del potencial antimicrobiano de los enjuagues bucales sobre la bacteria Streptococcus mutans. El objetivo de este estudio in vitro fue investigar los efectos antimicrobianos de los enjuagues bucales para niños contra esas bacterias. Materiales y Métodos: Se utilizó la cepa de S....
Abstract Chronic type 2 diabetes mellitus (T2DM) and its associated diseases are major concern among human population and also responsible for significant mortality rate. Hence, the present study aims to evaluate and correlate the invertase inhibition, antioxidant activity and control against DFU causing...
Nordihydroguaiaretic acid (NDGA) is a natural product obtained by the alkaline extraction of dried plants of Larrea tridentata species. Due to the biological properties presented, such as antioxidant, anti-inflammatory, antiviral and cytotoxic capacity, this compound is being increasingly studied. In thi...
Masoprocol/análisis,
Fenómenos Químicos,
Antioxidantes/farmacología,
Antivirales/farmacología,
Hipoglucemiantes/farmacología,
Modelos Animales,
Neoplasias,
Plantas/clasificación,
Productos Biológicos/análisis,
Toxicidad,
Técnicas In Vitro/métodos
To overcome the problems associated with bioavailability and systemic side effects of the drug by oral administration, monolithic matrix type transdermal patches containing cinnarizine (CNZ) were developed. For this purpose, films based on hydroxypropyl methylcellulose and polyvinylpyrrolidone as matrix-...
