BACKGROUND: Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target. METHODS: HT22 cells were cultured in 25 or 50 mM ...
Hipocampo/efectos de los fármacos,
Factor 2 Relacionado con NF-E2/agonistas,
Neuroprotección,
Glucosa/toxicidad,
Western Blotting,
Línea Celular,
Electroforesis en Gel de Campo Pulsado,
Técnica del Anticuerpo Fluorescente,
Hipocampo/citología,
Especies Reactivas de Oxígeno,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo
ABSTRACT The ability of four Aspergillus strains for biosynthesis of kojic acid was evaluated among which Aspergillus terreus represented the highest level (2.21 g/L) of kojic acid production. Improvement kojic acid production ability of A. terreus by random mutagenesis using different exposure time to u...
Alanine mother liquor, a type of industrial waste from alanine fermentation, was used as a nitrogen source to produce docosahexaenoic acid (DHA) by Schizochytrium sp. B4D1. The results indicated that yeast extract could trigger the utilization of the alanine mother liquor. Additionally, the alanine can b...
Abstract The cattle tick Rhipicephalus (Boophilus) microplus is an ectoparasite capable of transmitting a large number of pathogens, causing considerable losses in the cattle industry, with substantial damage to livestock. Over the years, important stages of its life cycle, such as the embryo, have been...
Objetivos: Investigar las características de los componentes del Síndrome Metabólico (SM) entre pacientes con glucosa normal y disglicemia en ayunas en la población adulta de Trujillo. Material y métodos: Estudio de análisis secundario tipo descriptivo, comparativo, relacional. Se analizó base de ...
Abstract Cellulosimicrobium cellulans CWS2, a novel strain capable of utilizing benzo(a)pyrene (BaP) as the sole carbon and energy source under nitrate-reducing conditions, was isolated from PAH-contaminated soil. Temperature and pH significantly affected BaP biodegradation, and the strain exhibited enha...
Actinobacteria/clasificación,
Actinobacteria/aislamiento & purificación,
Actinobacteria/metabolismo,
Anaerobiosis,
Benzo(a)pireno/metabolismo,
Biotransformación,
Cadmio/metabolismo,
Carbono/metabolismo,
Ácidos Carboxílicos/metabolismo,
Medios de Cultivo/química,
Inhibidores Enzimáticos/metabolismo,
Cromatografía de Gases y Espectrometría de Masas,
Glucosa/metabolismo,
Concentración de Iones de Hidrógeno,
Microbiología del Suelo,
Contaminantes del Suelo/metabolismo,
Temperatura
Abstract Objective: The present study aimed the functional recovery evaluation after long term of cardiac arrest induced by Custodiol (crystalloid-based) versus del Nido (blood-based) solutions, both added lidocaine and pinacidil as cardioplegic agents. Experiments were performed in isolated rat heart p...
Western Blotting,
Soluciones Cardiopléjicas/química,
Soluciones Cardiopléjicas/farmacología,
Proteínas Portadoras/análisis,
Vasos Coronarios/fisiopatología,
Glucosa/química,
Glucosa/farmacología,
Corazón/efectos de los fármacos,
Paro Cardíaco Inducido/métodos,
Lidocaína/farmacología,
Manitol/química,
Manitol/farmacología,
Proteínas de Microfilamentos/análisis,
Reperfusión Miocárdica/métodos,
Pinacidilo/farmacología,
Compuestos de Potasio/farmacología,
Factores de Tiempo,
Resistencia Vascular/fisiología,
Ratas Wistar
Martínez Álvarez, Andrea;
López Pompey, Néstor;
Villada, Óscar Alonso;
Lenis, Germán;
Corrales, Mauricio;
Cala, Hernando;
Guerra, Álvaro;
Toro, Luis;
Correa, Elizabeth;
Calle, Luisa;
Becerra Romero, Jorge Andrés.
Resumen Objetivo: se realizó un estudio en pacientes sometidos a trasplante de hígado (TH) con el objetivo de determinar los valores de glucemia en cada una de las fases de la cirugía del TH y su relación con la morbimortalidad postoperatoria. Materiales y métodos: se identificaron los trasplant...
El Índice Glucémico (IG) es un parámetro que indica el impacto agudo de los carbohidratos de un alimento sobre los niveles de Glucosa en sangre, por tanto, la cantidad y tipo de carbohidratos son los principales factores determinantes de la glucemia. En diabéticos, los alimentos con IG bajo tienen un...
Abstract Objective: Roux-en-Y gastric bypass (RYGB) reduces body weight and the comorbidities associated with obesity. The aim of this study was to evaluate whether glucose and lipid profiles were maintained during a 5-year follow-up period after RYGB. Subjects and methods: Anthropometric and laborator...
