Nizatidine is an anti-secretogogue and a gastroprotective drug with a half-life of 1-2 h and is well absorbed in the stomach. This study aimed to optimize the process and develop floating microparticles of nizatidine that are based on low methoxyl pectin. Oil-in-oil dispersion method and Taguchi orthogon...
Abstract In the recent past, drug delivery through nanoparticles is considered an effective tool to treat various diseases. Biopolymeric nanoparticles such as protein based nanoparticles have vital role as drug carrier as it is non-antigenic, and easily biodegradable. Curcumin, plant polyphenolic antican...
Técnicas In Vitro,
Nanopartículas,
Caseínas,
Curcumina,
Apoptosis,
Concentración 50 Inhibidora,
Células A549,
Liberación de Fármacos,
Antineoplásicos/farmacología,
Curcumina/farmacocinética,
Antineoplásicos/farmacocinética
Rocha, Mackson Martins;
Dariva, Isabela;
Zornoff, Gabriela Comelli;
De Laurentis, Giovanna Sanches;
Mendes, Giulia Carli;
Santana, Maycon Giovani;
Miguel, Guilherme Chohfi de;
Ferreira Junior, Rui Seabra;
Sciani, Juliana Mozer;
Priolli, Denise Gonçalves.
Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melitt...
ABSTRACT Objective To evaluate the marginal adaptation of computer-aided designing and computer-aided machining (CAD/CAM) fabricated cobalt-chromium and zirconium-oxide-based ceramic crowns compared to those produced by a conventional method. Material and Methods The study consists of three groups; 45 ...
Técnicas In Vitro,
Coronas,
Diseño Asistido por Computadora,
Circonio,
Aleaciones de Cromo,
Aleaciones de Cerámica y Metal,
Análisis de Varianza,
Adaptación Marginal Dental,
Prótesis Dental/instrumentación,
Porcelana Dental,
India
Abstract In the present research investigation, various concentrations of hydro-alcoholic extract of Saraca asoca (Roxb.) De Wilde (family: Caesalpinaceae) dried bark and carbopol polymer at different temperature ranges were optimized for the preparation of gel formulation. Natural penetration enhancers,...
Abstract Dyslipidemia is an abnormal lipid profile associated with many common diseases, including coronary heart disease and atherosclerosis. Cholesteryl ester transfer protein (CETP) is a hydrophobic plasma glycoprotein that is responsible for the transfer of cholesteryl ester from high-density lipopro...
Abstract Sporothrix spp. are the major dimorphic fungus associated with a type of subcutaneous mycosis, sporotrichosis. The limitation of antifungal availability and the past reports of in vitro resistance of Sporothrix spp. clinical isolates makes it important to search for new compounds with antifungal...
Abstract In drug therapy, it is important to provide therapeutic levels of drug to the site of action and maintain them during the treatment. This work describes the in vitro release of alendronate from sodium alginate cross-linked Montmorillonite (MMT) composite beads. Effect of crosslinking cation, con...
Abstract The Brazilian native species Cestrum intermedium, known as mata-boi, induces hepatotoxicity and death when ingested by cattle. While most studies on this species focus on toxicological features, our study is the first to describe the anatomy and in vitro biological activities of Cestrum intermed...
Abstract Sustained release matrix tablets of 100 mg losartan potassium HCl were fabricated with two
release retarding polymers namely HPMC K100 M and affinisol by direct compression method.
Nine trial formulations were prepared by varying content of these polymers, each from 50 mg
to 100 mg; keeping the...
