Results: 467

Cytotoxic activity of antineoplastic agents on fertility: a systematic review

Abstract Objective: To analyze the long-term effects of antineoplastic treatments on patient fertility. Selection of Studies: The studies were selected through the New PubMed, Scielo and Lilacs databases along with references used for the creation of the present work. For the selection of studies, arti...

Laser doppler flowmetry as a method of analysis for the evaluation of chemo - induced oral mucositis: a pilot study

J. oral res. (Impresa); 9 (5), 2020
Background: Oral mucositis (OM) is an inflammation of the oral mucosa due to cancer therapy that compromises the patient’s quality of life. Laser Doppler flowmetry (LDF) is a non-invasive method to monitor microvascular blood flow (BF) in real-time. Purpose: Develop a method to evaluate BF in the genia...

mRNAs biomarker related to the control of proliferation and cell death in HepG2/C3A spheroid and monolayer cultures treated with piperlongumine

Appl. cancer res; 40 (), 2020
Background: Cell culture (spheroid and 2D monolayer cultures) is an essential tool in drug discovery. Piperlongumine (PLN), a naturally occurring alkaloid present in the long pepper (Piper longum), has been implicated in the regulation of GSTP1 activity. In vitro treatment of cancer cells with PLN increa...

Tumores desmoides: consideraciones diagnóstico-terapéuticas

Gac. méd. Méx; 156 (5), 2020
Resumen Se realizó una revisión bibliográfica de los tumores desmoides, lo cuales afectan los tejidos blandos con un comportamiento localmente agresivo sin capacidad de producir metástasis. Los casos esporádicos se localizan en extremidades y pared torácica; los casos hereditarios tienen predilecci...

Scalp cooling to prevent chemotherapy-induced alopecia

An. bras. dermatol; 95 (5), 2020
Abstract Chemotherapy-induced alopecia causes an important impact on cancer patients and its risk of persistence is currently a considerable issue in cancer survivors. Of the various interventions proposed for the prevention of chemotherapy-induced alopecia, scalp cooling has emerged as an effective and ...

Ototoxicity of cypermethrin in Wistar rats

Abstract Introduction: This study presents the effect of cypermethrin on the cochlear function in Wistar rats post-subchronic inhalation exposure. Worldwide several pesticides are described as causing health disorders. Cypermethrin is currently one of the most commonly used, however, little is known abo...

Adaptación transcultural del componente de síntomas gastrointestinales de la escala CTCAE versión 4. 02

Rev. colomb. cancerol; 24 (3), 2020
Resumen Objetivo: Realizar la traducción y adaptación transcultural del componente de síntomas gastrointestinales (SGI) de la escala CTCAE versión 4.02 en pacientes ambulatorios tratados con quimioterapia en el Instituto Nacional de Cancerología en Bogotá. Métodos: Se realizó una búsqueda manu...

Renal tuberculosis in an imatinib-treated chronic myeloid leukemia

J. bras. nefrol; 42 (3), 2020
ABSTRACT Imatinib, which inhibits tyrosine kinase activity of Bcr-Abl protein, is a standard form of treatment for chronic myeloid leukemia (CML). Through its immunomodulatory effect it affects T cell function in a number of ways. It inhibits antigen-induced T cell activation and proliferation. Antigen-s...

Aspectos clínicos, laboratoriais e tratamento da leucemia mieloide crônica em cão: relato de caso

Rev. bras. ciênc. vet; 27 (3), 2020
O objetivo deste relato é apresentar o caso clínico de uma cadela, sem raça definida, com cinco anos de idade, diagnosticada com leucemia mieloide crônica (LMC). As leucemias são neoplasias malignas que se originam de células precursoras da medula óssea e as consequências podem ser trombocitopeni...