Abstract Heart transplantation is an effective treatment for Chagas disease patients with severe cardiomyopathy. However, Trypanosoma cruzi reactivation is of great concern. The T. cruzi parasite is classified into six discrete typing units (DTUs identified as TcI-TcVI). It is unknown whether there is an...
Cardiomiopatía Chagásica/tratamiento farmacológico,
Cardiomiopatía Chagásica/cirugía,
ADN Protozoario,
Variación Genética,
Genotipo,
Trasplante de Corazón/efectos adversos,
Inmunosupresores/uso terapéutico,
Persona de Mediana Edad,
Nitroimidazoles/uso terapéutico,
Reacción en Cadena de la Polimerasa,
Tripanocidas/uso terapéutico
Monoclonal gammopathy of renal significance (MGRS) can present with different morphologic features and lead to kidney failure. The Henoch-Schönlein purpura nephritis (HSPN) that cannot be relieved by treatment with glucocorticoid and immunosuppressive agents suggests the presence of monoclonal gammopath...
Glucocorticoides/administración & dosificación,
Inmunosupresores/administración & dosificación,
Nefritis/complicaciones,
Nefritis/tratamiento farmacológico,
Nefritis/patología,
Paraproteinemias/tratamiento farmacológico,
Paraproteinemias/etiología,
Paraproteinemias/patología,
Vasculitis por IgA/complicaciones,
Vasculitis por IgA/tratamiento farmacológico,
Vasculitis por IgA/patología
ABSTRACT Case report of a patient with severe atopic dermatitis who showed a good response to dupilumab. She had already used two immunosuppressive agents, cyclosporine A and mycophenolate mofetil, for the treatment of atopic dermatitis with no proper control of the disease. She had also been taking all ...
Anticuerpos Monoclonales/administración & dosificación,
Anticuerpos Monoclonales Humanizados,
Brasil,
Dermatitis Atópica/tratamiento farmacológico,
Terapia de Inmunosupresión,
Inmunosupresores/administración & dosificación,
Inyecciones Subcutáneas,
Interleucina-13,
Interleucina-4,
Calidad de Vida,
Índice de Severidad de la Enfermedad
OBJECTIVES: The aim of this study was to evaluate the quantitative serum level of infliximab (IFX) as well as the detection of anti-infliximab antibodies (ATIs) in patients with Crohn's disease (CD). METHOD: Forty patients with CD under treatment at a tertiary center in southeastern Brazil were evaluate...
Anticuerpos Monoclonales/sangre,
Brasil,
Enfermedad de Crohn/sangre,
Enfermedad de Crohn/tratamiento farmacológico,
Relación Dosis-Respuesta a Droga,
Monitoreo de Drogas,
Quimioterapia Combinada,
Fármacos Gastrointestinales/sangre,
Fármacos Gastrointestinales/uso terapéutico,
Inmunosupresores/uso terapéutico,
Infliximab/sangre,
Infliximab/uso terapéutico,
Estudios Prospectivos
Abstract Purpose To assess Cyclosporine A (CsA) therapy at an intraperitoneal dose of 15 mg.kg -1 in a rodent model of non-septic renal ischemia. Methods Twenty male Wistar rats were randomized to receive CsA therapy or none therapy before undergoing 30 minutes of renal ischemia followed by reperfusion...
Creatinina/sangre,
Ciclosporina/farmacología,
Modelos Animales de Enfermedad,
Inmunosupresores/farmacocinética,
Isquemia/prevención & control,
Riñón/irrigación sanguínea,
Riñón/efectos de los fármacos,
Ratas Wistar,
Daño por Reperfusión/tratamiento farmacológico,
Daño por Reperfusión/patología,
Sodio/sangre,
Urea/sangre
Abstract Purpose To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart failure. Methods Pressure overload-induced heart failure model (abdominal aortic coarctation) was established in 40 rats, which were divided into model and 5, 10 an...
ABSTRACT Objective: To describe the incidence of active tuberculosis and the occurrence of adverse events after isoniazid treatment in patients with latent tuberculosis infection (LTBI) who also had chronic inflammatory diseases and were treated with immunobiologic agents in an endemic area in Brazil. ...
Profilaxis Antibiótica/métodos,
Antituberculosos/uso terapéutico,
Brasil/epidemiología,
Enfermedades Endémicas,
Factores Inmunológicos/uso terapéutico,
Inmunosupresores/uso terapéutico,
Isoniazida/uso terapéutico,
Tuberculosis Latente/diagnóstico,
Tuberculosis Latente/tratamiento farmacológico,
Tuberculosis Latente/epidemiología,
Análisis Multivariante,
Estudios Prospectivos,
Radiografía Torácica,
Factores de Riesgo,
Factores de Tiempo,
Resultado del Tratamiento,
Prueba de Tuberculina/métodos
Introdução: Imunossupressores apresentam alta toxicidade associada à estreita faixa terapêutica, devendo-se ter controle de níveis séricos. Assim, é necessário o estudo de utilização de medicamentos em clínicas que os utilizam, fornecendo uma visão geral de seu consumo e uso racional em uma d...
Abstract Background: Recommendations of the Myopathy Committee of the Brazilian Society of Rheumatology for the management and therapy of systemic autoimmune myopathies (SAM). Main body: The review of the literature was done in the search for the Medline (PubMed), Embase and Cochrane databases includin...
Enfermedades Autoinmunes/tratamiento farmacológico,
Glucocorticoides/uso terapéutico,
Inmunosupresores/uso terapéutico,
Enfermedades Musculares/tratamiento farmacológico,
Enfermedades Autoinmunes/rehabilitación,
BiomarcadoresSangre,
Brasil,
Dermatomiositis/terapia,
Ejercicio Físico,
Terapia por Ejercicio,
Glucocorticoides/efectos adversos,
Inmunoglobulinas Intravenosas/uso terapéutico,
Inmunosupresores/efectos adversos,
Metilprednisolona/administración & dosificación,
Metilprednisolona/efectos adversos,
Enfermedades Musculares/rehabilitación,
Educación del Paciente como Asunto,
Polimiositis/terapia,
Prednisona/administración & dosificación,
Prednisona/efectos adversos,
Ensayos Clínicos Controlados Aleatorios como Asunto,
Reumatología,
Rituximab/uso terapéutico,
Sociedades Médicas
