Results: 399

Quality of Life in Iranian Patients with Oral and Head and Neck Cancer

ABSTRACT Objective: To assess sociodemographic factors and cancer information on patients' quality of life with head and neck cancer. Material and Methods: This cross-sectional study was conducted on 69 patients with head and neck cancer who attended in one of the oncology centers in Mashhad, Iran, fro...

Salivary molecules of bone remodeling and tissue repair after head and neck radiotherapy

Abstract Head and neck radiotherapy causes quantitative and qualitative changes in saliva. The objective of this case-control study was to evaluate the salivary biomarkers associated with bone remodeling and tissue repair in patients submitted to radiotherapy for head and neck cancer treatment, compared ...

Oncogenic circDHTKD1 promotes tumor growth and metastasis of oral squamous cell carcinoma in vitro and in vivo via upregulating miR-326-mediated GAB1

Braz. j. med. biol. res; 54 (10), 2021
Circular RNAs (circRNAs) have been extensively elucidated with regard to their significant implications in oral squamous cell carcinoma (OSCC). This study performed the functional investigation of circRNA dehydrogenase E1 and transketolase domain containing 1 (circDHTKD1) in OSCC. RNA expression levels o...

Relationship between anemia and oral cancer: a case-control study

Abstract The aim of this study was to investigate the occurrence, type and severity of anemia at the time of diagnosis of oral cancer, and its potential association with the degree of tumor cell differentiation. This case-control study used 366 medical records of patients treated at two referral centers ...

Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma

J. appl. oral sci; 29 (), 2021
Abstract Objective To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). Methodology Total 217cases of OSCC primarily treated with surgery with or without radiation were included. ...

Impacto da Radiodermatite na estética corporal de pacientes com câncer de cabeça e pescoço

Rev. enferm. UFSM; 11 (), 2021
Objetivo: descrever o impacto da radiodermatite na estética corporal em pacientes com câncer de cabeça e pescoço submetidos à radioterapia. Método: estudo exploratório descritivo, do tipo série de casos, realizado no ambulatório de radioterapia de um hospital de ensino. Foram incluídos dez paci...

MET overexpression and intratumor heterogeneity in esophageal squamous cell carcinoma

Braz. j. med. biol. res; 54 (8), 2021
Esophageal squamous cell carcinoma (ESCC) is among the ten most frequent and deadly cancers, without effective therapies for most patients. More recently, drugs targeting deregulated growth factor signaling receptors have been developed, such as HGF-MET targeted therapy. We assessed MET and HGF genetic a...

Aumento da hiperdensidade da cortical óssea línguo-basal após radioterapia em região de cabeça e pescoço: relato de caso

RFO UPF; 25 (3), 2020
Objetivo: relatar um caso de aumento da hiperdensidade da cortical óssea línguo-basal pós-radioterapia em região de cabeça e pescoço por meio de avaliação imaginológica. Relato de caso: paciente do sexo feminino, 80 anos, procurou tratamento odontológico com a finalidade de reabilitação oral ...

Aplicación del análisis de componentes principales en la formación de dímeros durante la purificación de un anticuerpo monoclonal
Application of Principal Component Analysis on dimers formation during a monoclonal antibodys purification

El producto Nimotuzumab, altamente demandado para el tratamiento de cáncer de cabeza y cuello, se produce en el Centro de Inmunología Molecular a partir del cultivo, fermentación y purificación en la línea NS0/H7. El uso de tecnologías adecuadas para la producción a gran escala de anticuerpos mono...