Abstract Doxorubicin (Dox) is a medication used in the treatment of cancerous tumors and hematologic malignancies with potentially serious side effects, including the risk of cardiotoxicity. Flavonoids are plant metabolites with antioxidant properties and can be extracted from Camellia sinensis (CS). The...
Abstract The article explores the significance of biomarkers in clinical research and the advantages of utilizing artificial intelligence (AI) and machine learning (ML) in the discovery process. Biomarkers provide a more comprehensive understanding of disease progression and response to therapy compared ...
Abstract Biological activity of boron-containing compounds (BCCs) has been well-known. Growing interest and numerous applications for BCCs have been reported. Boron and boron-containing acids show low acute toxicity in mammals but data on halogenated boroxine (HB) - dipotassium-trioxohydroxytetrafluorotr...
Desarrollo de Medicamentos/instrumentación,
Boro/agonistas,
Pruebas de Toxicidad Aguda/instrumentación,
Antioxidantes/farmacología,
d0099340,
Productos Biológicos/efectos adversos,
Técnicas In Vitro/métodos,
d0001430,
d0079280,
d0207140,
ddcs0516950
Abstract This study aimed to investigate the molecular mechanism of Picrasma quassioides Benn against inflammation by means of network pharmacology. The paper will provide a reference for multi-target and multi-channel treatment of inflammation with traditional Chinese medicine. Through screening and ana...
Abstract Donepezil-HCl is a member of the acetylcholinesterase inhibitors that is indicated for the symptomatic treatment of Alzheimer’s disease (AD) and has many side effects. In this study, to reduce the side effects of Donepezil-HCl and increase the penetration of the drug through the blood-brain ba...
Abstract Currently, mucosal vaccine administration has stood out as an easier and non-invasive application method. It can also be used to induce local and systemic immune responses. In the COVID-19 pandemic context, nasal and oral vaccines have been developed based on different technological platforms. T...
Abstract The genus Candida represents the main cause of infections of fungal origin. Some species stand out as disease promoters in humans, such as C. albicans, C. glabrata, C. parapsilosis, and C. tropicalis. This study evaluated the antifungal effects of propyl (E)-3-(furan-2-yl) acrylate. The minimum ...
Guimarães, Gabriel Macedo Costa;
Faustino, Renan;
Oliveira, Any Caroline;
Alves, Lilian Santos;
Carvalho, Fabiana Rabe;
Baptista, Katia Lino;
Yaginuma, Karina Yuriko;
Santos, Hugo Henrique Kegler dos;
Almeida, Jorge Reis;
Medeiros, Thalia;
Silva, Andrea Alice.
Abstract This study aimed to evaluate the hematological and coagulation parameters according to the clinical outcomes of coronavirus disease (COVID-19). We analyzed the hematological and coagulation parameters of hospitalized patients with COVID-19 at admission, and two and three weeks during hospitaliza...
Abstract Development of ceftriaxone loaded nanostructured lipid carriers to increase permeability of ceftriaxone across uninflamed meninges after parenteral administration. Lipids were selected by theoretical and experimental techniques and optimization of NLCs done by response surface methodology using ...
Triaje/clasificación,
Lípidos/análisis,
Ceftriaxona/agonistas,
Difracción de Rayos X/instrumentación,
Infecciones del Sistema Nervioso Central/patología,
d0045260,
ddcs0502240,
d0043640,
d0084030,
d0129950,
Técnicas In Vitro/métodos
Abstract Hydrocotyle umbellata L., Araliaceae, is a species that is recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite the medicinal potential of this species, its phytopharmaceutical and technological potential to pro...
