Paracetamol (also called acetaminophen, or APAP) overdose causes acute damage to the liver and kidneys in both humans and experimental animal models via the induction of the oxidative stress pathway. We sought to determine whether the combined antioxidants and anti-inflammatory compounds, resveratrol (RE...
Lesión Renal Aguda/inducido químicamente,
Lesión Renal Aguda/tratamiento farmacológico,
Acetaminofén/toxicidad,
Resveratrol/uso terapéutico,
Quercetina/uso terapéutico,
Acetaminofén/antagonistas & inhibidores,
Modelos Animales de Enfermedad,
Quimioterapia Combinada,
Antioxidantes/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Resveratrol/farmacología,
Quercetina/farmacología
Abstract Purpose: Myocardial ischemia/reperfusion (Ml/R) injury is a leading cause of damage in cardiac tissues, with high rates of mortality and disability. Biochanin A (BCA) is a main constituent of Trifolium pratense L. This study was intended to explore the effect of BCA on Ml/R injury and explore t...
Antiinflamatorios/farmacología,
Aspartato Aminotransferasas/sangre,
Western Blotting,
Cardiotónicos/farmacología,
Creatina Quinasa/sangre,
Citocinas/sangre,
Genisteína/farmacología,
Lactato Deshidrogenasas/sangre,
Daño por Reperfusión Miocárdica/metabolismo,
Daño por Reperfusión Miocárdica/prevención & control,
FN-kappa B/efectos de los fármacos,
FN-kappa B/metabolismo,
Proteína con Dominio Pirina 3 de la Familia NLR/efectos de los fármacos,
Ratas Sprague-Dawley,
Valores de Referencia,
Reproducibilidad de los Resultados,
Transducción de Señal/efectos de los fármacos,
Receptor Toll-Like 4/efectos de los fármacos,
Receptor Toll-Like 4/metabolismo
Annona nutans (Annonaceae) is a plant species found in Bolivia, Paraguay, Argentina, and the Brazilian Cerrado, specifically in the states of Mato Grosso and Mato Grosso do Sul (Brazil). Its common names are Araticû-Mi and Araticû-Ñu. The research contributions regarding the ch...
ABSTRACT A 27-year-old man presented with a complaint of decreased visual acuity in the right eye. Best-corrected visual acuity was 20/60 in the right eye and 20/20 in the left eye. Right eye fundoscopy revealed mild vitritis, multifocal yellowish lesions, and macular serous retinal detachment. Left eye ...
Enfermedad Aguda,
Antiinflamatorios/uso terapéutico,
Antibióticos Antituberculosos/uso terapéutico,
Angiografía con Fluoresceína,
Epitelio Pigmentado Ocular/diagnóstico por imagen,
Prednisona/uso terapéutico,
Enfermedades de la Retina/diagnóstico,
Enfermedades de la Retina/tratamiento farmacológico,
Tomografía de Coherencia Óptica,
Tuberculosis Ocular/diagnóstico,
Tuberculosis Ocular/tratamiento farmacológico,
Agudeza Visual
Objective: To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by lipopolysaccharides (LPS) has a cumulative effect on subsequent stimuli in this model. We also evaluated the action of lithium (Li) on inflamma...
Antiinflamatorios/farmacología,
Trastorno Bipolar/inducido químicamente,
Trastorno Bipolar/inmunología,
Trastorno Bipolar/fisiopatología,
Factor Neurotrófico Derivado del Encéfalo/sangre,
Citocinas/sangre,
Modelos Animales de Enfermedad,
Ensayo de Inmunoadsorción Enzimática,
Lipopolisacáridos/farmacología,
Dimesilato de Lisdexanfetamina,
Litio/farmacología,
Locomoción/efectos de los fármacos,
Factores de Crecimiento Nervioso/efectos de los fármacos,
Óxido Nítrico Sintasa de Tipo II/sangre,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento
Resumo A febre Chikungunya é um problema de saúde pública mundial, com potencial para gerar epidemias de alta morbidade, visto que elevado número de pacientes pode apresentar sequelas articulares prolongadas e alterações oftalmológicas. As manifestações oftalmológicas podem estar presentes na f...
Fiebre Chikungunya/complicaciones,
Fiebre Chikungunya/tratamiento farmacológico,
Fiebre Chikungunya/diagnóstico,
Fiebre Chikungunya/sangre,
Fiebre Chikungunya/epidemiología,
Pruebas Serológicas/métodos,
Virus Chikungunya/aislamiento & purificación,
Virus Chikungunya/inmunología,
Oftalmopatías/etiología,
Oftalmopatías/tratamiento farmacológico,
Oftalmopatías/diagnóstico,
Antivirales/uso terapéutico,
Cloroquina/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Corticoesteroides/uso terapéutico
O objetivo deste estudo foi avaliar a utilidade do teste de provocação oral (TPO) em pacientes encaminhados para investigação de reações alérgicas a medicamentos. Foi realizado um estudo analítico, transversal, com coleta de dados de pacientes de 0 a 14 anos, com história de reação adversa a m...
Surgical extraction of impacted lower wisdom teeth is a frequent minor intraoral surgical process. It is regularly linked with aching and postoperative consequences as pain and swelling. The aim of this study is to evaluate the efficacy of two methods in reducing swelling and pain subsequent to the remov...
ABSTRACT In this review, we discuss the therapies used in the treatment of patients with Duchenne muscular dystrophy since the first description of the disease. A short description is given of the various theories based on disease pathogenesis, which give the substrates for the many therapeutic intervent...
