El cáncer gástrico (CG) es un problema prevalente a nivel mundial, presentándose aproximadamente 18 millones de casos nuevos en el año 2018, representa el 5.7% del total de cánceres, siendo la quinta neoplasia maligna más común en el mundo. En Guatemala se sitúa entre los primeros cinco cánceres...
Receptores del Activador de Plasminógeno Tipo Uroquinasa,
Neoplasias Gástricas/tratamiento farmacológico,
Biomarcadores,
Helicobacter pylori,
Interleucina-1,
Interleucina-10,
Interleucina-17,
Interleucina-4,
Interleucina-6,
Mortalidad,
Neoplasias Gástricas/mortalidad
This study was designed to investigate the expression of RBM8A protein in patients with gastric cancer (GC) and to explore its correlation with clinical pathological features as well as prognosis. One hundred pairs of gastric carcinoma tissues and adjacent tissues from patients undergoing gastrectomy for...
Biomarcadores de Tumor/genética,
Mucosa Gástrica/patología,
Regulación Neoplásica de la Expresión Génica,
Inmunohistoquímica,
Metástasis Linfática/patología,
Metástasis de la Neoplasia,
Estadificación de Neoplasias,
Pronóstico,
Proteínas Proto-Oncogénicas/metabolismo,
ARN Mensajero/metabolismo,
Proteínas de Unión al ARN/genética,
Proteínas de Unión al ARN/metabolismo,
Neoplasias Gástricas/genética,
Neoplasias Gástricas/metabolismo,
Neoplasias Gástricas/patología,
Análisis de Supervivencia
BACKGROUND: Tumor angiogenesis is an essential event for tumor growth and metastasis. It has been showed that REC8, a component of the meiotic cohesion complex, played a vital role in Epithelial-Mesenchymal Transition (EMT) in gastric cancer. However, the role of REC8 in gastric cancer angiogenesis remai...
Resumen El cáncer gástrico, patología neoplásica de innegable importancia, corresponde en el 90 % de los casos a un adenocarcinoma. Dentro del 10 % restante, los linfomas y los tumores estromales gastrointestinales (Gastrointestinal Stromal Tumor, GIST) constituyen la mayoría. Sin embargo, los sarco...
The development of chemotherapy resistance significantly impairs the efficiency of chemotherapy, but the underlying mechanisms of chemotherapy resistance in gastric cancer (GC) are complicated and still need to be further explored. Here, we aimed to reveal the effects of miR-4290/PDK1 (pyruvate dehydroge...
Apoptosis/efectos de los fármacos,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Cisplatino/farmacología,
Resistencia a Antineoplásicos/genética,
Citometría de Flujo,
Regulación Neoplásica de la Expresión Génica,
Glucólisis/genética,
MicroARNs/metabolismo,
Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/genética,
Piruvato Deshidrogenasa Quinasa Acetil-Transferidora/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Neoplasias Gástricas/metabolismo,
Transfección
BACKGROUND: Previous studies have shown that long noncoding RNA (IncRNA) LINC00483 was aberrantly expressed in human cancers, including gastric cancer. However, the regulatory mechanism of this IncRNA in gastric cancer remains largely unknown. The present study aimed to investigate the effect of LINC0048...
MicroARNs/metabolismo,
Proteína Quinasa 1 Activada por Mitógenos/metabolismo,
ARN Largo no Codificante/metabolismo,
Neoplasias Gástricas/metabolismo,
Carcinogénesis/metabolismo,
Línea Celular Tumoral/metabolismo,
Células Epiteliales/metabolismo,
Luciferasas/metabolismo,
MicroARNs/genética,
ARN Largo no Codificante/genética,
Neoplasias Gástricas/genética,
Apoptosis,
Movimiento Celular,
Supervivencia Celular,
Regulación Neoplásica de la Expresión Génica,
Ratones Endogámicos BALB C,
Ensayos Antitumor por Modelo de Xenoinjerto
Paclitaxel spirulina nanoparticles were said to have promising anticancer activity against gastric cancer. Nanoparticles of paclitaxel-spirulina were prepared for treating gastric cancer using precipitation technique. The synergistic anticancer efficiency againstMKN45 cells retains when the paclitaxel an...
Barchi, Leandro Cardoso;
Ramos, Marcus Fernando Kodama Pertille;
Dias, André Roncon;
Andreollo, Nelson Adami;
Weston, Antônio Carlos;
Lourenço, Laércio Gomes;
Malheiros, Carlos Alberto;
Kassab, Paulo;
Zilberstein, Bruno;
Ferraz, Álvaro Antônio Bandeira;
Charruf, Amir Zeide;
Brandalise, André;
Silva, André Maciel da;
Alves, Barlon;
Marins, Carlos Augusto Martinez;
Leite, Celso Vieira;
Bresciani, Claudio José Caldas;
Szor, Daniel;
Mucerino, Donato Roberto;
Wohnrath, Durval R;
Ilias, Elias Jirjoss;
Martins Filho, Euclides Dias;
Lopasso, Fabio Pinatel;
Coimbra, Felipe José Fernandez;
Felippe, Fernando E. Cruz;
Tomasisch, Flávio Daniel Saavedra;
Takeda, Flavio Roberto;
Ishak, Geraldo;
Laporte, Gustavo Andreazza;
Silva, Herbeth José Toledo;
Cecconello, Ivan;
Rodrigues, Joaquim José Gama;
Grande, José Carlos Del;
Motta, Leonardo Milhomem da;
Ferraz, Leonardo Rocha;
Moreira, Luis Fernando;
Lopes, Luis Roberto;
Toneto, Marcelo Garcia;
Mester, Marcelo;
Rodrigues, Marco Antônio Gonçalves;
Carvalho, Marineide Prudêncio de;
Franciss, Maurice Youssef;
Forones, Nora Manoukian;
Corletta, Oly Campos;
Yagi, Osmar Kenji;
Castro, Osvaldo Antonio Prado;
Malafaia, Osvaldo;
Assumpção, Paulo Pimentel;
Savassi-Rocha, Paulo Roberto;
Colleoni Neto, Ramiro;
Oliveira, Rodrigo Jose de;
Sallun, Rubens Antonio Aissar;
Weschenfelder, Rui;
Oliveira, Saint Clair Vieira de;
Abreu, Thiago Boechat de;
Castria, Tiago Biachi de;
Ribeiro Junior, Ulysses;
Barra, Williams;
Costa Júnior, Wilson Luiz da;
Freitas Júnior, Wilson Rodrigues de.
ABSTRACT Background: Since the publication of the first Brazilian Consensus on Gastric Cancer (GC) in 2012 carried out by the Brazilian Gastric Cancer Association, new concepts on diagnosis, staging, treatment and follow-up have been incorporated. Aim: This new consensus is to promote an update to prof...
Barchi, Leandro Cardoso;
Ramos, Marcus Fernando Kodama Pertille;
Yagi, Osmar Kenji;
Mucerino, Donato Roberto;
Bresciani, Claudio José Caldas;
Ribeira Júnior, Ulysses;
Andreollo, Nelson Adami;
Assumpção, Paulo Pimentel;
Weston, Antônio Carlos;
Colleoni Neto, Ramiro;
Zilberstein, Bruno.
The II Brazilian Consensus on Gastric Cancer by the Brazilian Gastric Cancer Association (ABCG) was recently published. On this occasion, several experts in gastric cancer expressed their opinion before the statements presented. Aim: To present the ABCG Guidelines (part 1) regarding the diagnosis, stag...
ABSTRACT Background: Laparoscopic surgery has been gradually accepted as an option for the surgical treatment ofgastric cancer. There are still points that are controversial or situations that are eventually associated with intra-operative difficulties or postoperative complications. Aim: To establish...
