Results: 234

Radiolytic studies of cefozopran hydrochloride in the solid state

Background: The radiation sterilization is one of the best methods for sterilizing vulnerable degradation drugs like cefozopran hydrochloride. Results: Chemical stability of radiosterylized cefozopran hydrochloride, was confirmed by spectrophotometric and chromatographic methods. EPR studies showed that ...

Investigação das quinases Aurora A e Aurora B na tumorigenicidade mediada pelo oncogene KRAS

O câncer de pulmão é a principal causa de morte relacionada ao câncer no mundo. Mutações em KRAS são altamente prevalentes no câncer e têm sido diretamente associadas ao processo tumorigênico. Apesar disso, até hoje todas as terapias visando inibir KRAS diretamente falharam e a caracterizaçã...

Physical-chemical properties and cytotoxicity analysis of 5 different endodontic sealers

The aim of this study was to analyze the radiopacity, setting time, flowability, pH, calcium ion release, solubility and cytotoxicity of bioceramic cements Totalfill BC Sealer and Totalfill BC RRM, and compare them with AH Plus, MTA Fillapex and MTA Angelus. The groups were divided and compared among the...

Desenvolvimento e análise de bandagem de bioestimulação dentino/pulpar (BBio)

O desenvolvimento de biomateriais com aplicações na área da saúde mostram-se cada vez mais importantes e a procura por novos polímeros com propriedades bioativas, biodegradabilidade, atoxicidade são o foco das principais pesquisas em diferentes aplicações médicas e odontológicas. Os materiais c...

Efeito de campos magnéticos estáticos e compensados na proliferação celular in vitro

Inserido no paradigma da transdisciplinaridade, o presente trabalho foi desenvolvido em etapas, com os seguintes objetivos: a) Construir um dispositivo com base de metal não magnético para ímãs permanentes, visando à geração de um Campo Magnético Estático (CME) ou de um Campo Magnético Compensa...

Propofol inhibits lung cancer cell viability and induces cell apoptosis by upregulating microRNA-486 expression

Braz. j. med. biol. res; 50 (1), 2017
Propofol is a frequently used intravenous anesthetic agent. Recent studies show that propofol exerts a number of non-anesthetic effects. The present study aimed to investigate the effects of propofol on lung cancer cell lines H1299 and H1792 and functional role of microRNA (miR)-486 in these effects. H12...

CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-kappaB pathway

Braz. j. med. biol. res; 50 (4), 2017
Myocardial ischemia is a major cause of death and remains a disease with extremely deficient clinical therapies and a major problem worldwide. Cold inducible RNA-binding protein (CIRBP) is reported to be involved in multiple pathological processes, including myocardial ischemia. However, the molecular me...

Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis

Braz. j. med. biol. res; 50 (6), 2017
We aimed to investigate the effect of etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, on rat cardiomyocyte hypertrophy and its underlying mechanism. Primary neonatal rat cardiomyocytes were isolated from Sprague-Dawley rats. The model of rat cardiomyocyte hypertrophy was induced by end...

MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer

Braz. j. med. biol. res; 50 (6), 2017
Colorectal cancer (CRC) is the fourth leading cause of cancer-induced mortality. Histone deacetylase 2 (HDAC2) is involved in prognosis and therapy of CRC. This study aimed to explore novel therapeutic targets for CRC. The alteration of HDAC2 expression in CRC tissues was estimated by qRT-PCR. After lent...

FAMLF is a target of miR-181b in Burkitt lymphoma

Braz. j. med. biol. res; 50 (6), 2017
Burkitt lymphoma (BL) is a highly malignant non-Hodgkin's lymphoma that is closely related to the abnormal expression of genes. Familial acute myelogenous leukemia related factor (FAMLF; GenBank accession No. EF413001.1) is a novel gene that was cloned by our research group, and miR-181b is located in th...