El objetivo del presente estudio fue analizar el efecto del ácido clorogénico, uno de los compuestos polifenólicos con mayor concentración en la infusión de Ilex paraguariensis, sobre el daño celular y molecular inducido por el benzo(a)pireno. La infusión de Ilex paraguariensis ("mate") es bebida ...
Benzo(a)pireno/farmacología,
Ácido Clorogénico/farmacología,
Proteínas de Saccharomyces cerevisiae/efectos adversos,
Enzimas Reparadoras del ADN/genética,
Muerte Celular/efectos de los fármacos,
Tasa de Mutación,
Roturas del ADN de Doble Cadena/efectos de los fármacos,
Mutagénesis/efectos de los fármacos,
Muerte Celular/genética,
Antimutagênicos/farmacología,
Benzo(a)pireno/toxicidad,
Proteínas de Saccharomyces cerevisiae/genética
Purpose: To explore the effect and potential mechanism of dihydroartemisinin (DHA) on metabolism-related fatty liver disease. Methods: A metabolic associated fatty liver disease (MAFLD) mice model was induced with continuous supplies of high-fat diet. DHA was intraperitoneally injected into mice. The we...
Abstract Our aim was to evaluate the effects of cisplatin and dexamethasone alone and combined on gastric contractility and histomorphometry of BALB/c and C57BL/6 mice. BALB/c and C57BL/6 male mice (8-week-old) were randomly separated into: Control; Cisplatin (7.5 mg/Kg); Dexamethasone (2.0 mg/Kg); and D...
Abstract In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion profiles. Urine samples from a healthy volun...
Abstract The present study entails the systematic development and validation of a stability-indicating RP-HPLC method for the analysis of sitagliptin and ertugliflozin in a fixed-dose combination. Analytical quality by design (AQbD) concepts were used to define critical method variables, employing Pareto...
Abstract The genus Candida represents the main cause of infections of fungal origin. Some species stand out as disease promoters in humans, such as C. albicans, C. glabrata, C. parapsilosis, and C. tropicalis. This study evaluated the antifungal effects of propyl (E)-3-(furan-2-yl) acrylate. The minimum ...
Abstract Prolonged overexposure to catecholamines causes toxicity, usually credited to continuous adrenoceptor stimulation, autoxidation, and the formation of reactive pro-oxidant species. Non-differentiated SH-SY5Y cells were used to study the possible contribution of oxidative stress in adrenaline (ADR...
Neuronas/clasificación,
Toxicidad,
Epinefrina/agonistas,
Antioxidantes/farmacología,
Bromuros/antagonistas & inhibidores,
d0024770,
Enfermedades del Sistema Nervioso Periférico/clasificación,
Estrés Oxidativo/efectos de los fármacos,
d0077700,
Nervios Periféricos/anomalías,
d0119410
Santos, Thais Menezes dos;
Sousa, Danieli Silva Feijó de;
Di Piero, Karina Chamma;
Todeschini, Adriane Regina;
Dias, Wagner Barbosa;
Oliveira, Catarina Amorim;
Santos, Elisabete Pereira dos;
Monteiro, Mariana Sato de Souza Bustamante;
Gomes, Maria Kátia;
Moura, Cristiano dos Reis;
Teixeira, Pedro Antônio Castelo;
Ricci-Junior, Eduardo;
Freitas, Zaida Maria Faria de.
Abstract Hydrogels are used for wound treatment, as they may contain one or more active components and protect the wound bed. Papain is one of the active substances that have been used with this purpose, alongside urea. In this paper, carboxypolymethylene hydrogels containing papain (2% and 10% concentra...
Hormone-dependent breast cancer has growth factors that respond positively to the hormones estrogen and progesterone. Thus, adjuvant endocrine therapy causes decreased or undetectable serum levels of these hormones. However, this treatment can have side effects that compromise the sexual health of patie...
Abstract Oxazolidine derivatives (OxD) have been described as third-line antibiotics and antitumoral agents. The inclusion complexes based on cyclodextrin could improve the solubility and bioavailability of these compounds. A novel synthetic OxD was used, and its inclusion complexes were based on 2-hydro...
