The widespread use of antimicrobial chemotherapy in medicine and livestock production imposed an evolutive selection of drug-resistant strains worldwide. As a result, the effectiveness of our current antimicrobial armamentarium is constantly being reduced to alarming levels. Therefore, novel antimicrobia...
Bacterias/clasificación,
Antiinfecciosos/análisis,
Azul de Metileno/efectos adversos,
Eficacia,
Estrategias de Salud,
Estrés Oxidativo,
Fotoquimioterapia/instrumentación,
Preparaciones Farmacéuticas/administración & dosificación,
Quimioterapia/instrumentación,
Cinética,
Hongos/aislamiento & purificación,
Farmacorresistencia Bacteriana
Unprotected chronic exposure to ultraviolet radiation generates many harmful effects to
human skin and UV filters are essential to health, however, traditional sunscreens do not
provide enough protection against cutaneous oxidative stress, a process amplified by UV
radiation. Therefore, is been proposed ...
Protectores Solares/análisis,
Eficacia,
Rayos Ultravioleta/efectos adversos,
Neoplasias Cutáneas/clasificación,
Flujometría por Láser-Doppler/métodos,
Sustancias Reactivas al Ácido Tiobarbitúrico/farmacología,
Antiinflamatorios/análisis,
Antioxidantes/administración & dosificación,
Cosméticos/clasificación,
Cromatografía Líquida de Alta Presión/métodos,
Diagnóstico,
Estrés Oxidativo/efectos de los fármacos,
Factores Protectores,
Preparaciones Farmacéuticas/análisis,
Radiación
O objetivo deste estudo in vitro foi avaliar o efeito da aplicação de agentes antioxidantes após o clareamento dentário e previamente à cimentação de laminados cerâmicos na estabilidade cromática do conjunto restaurador, assim como nas propriedades mecânicas de nanodureza (HIT), módulo de elas...
Antioxidantes,
Blanqueamiento de Dientes,
Cerámica,
Dureza,
Módulo de Elasticidad,
Espectrometría por Rayos X,
Cementación,
Tocoferoles,
Cementos de Resina,
Cementos Dentales,
Propiedades de Superficie,
Peróxido de Hidrógeno,
Resistencia al Corte,
Ácido Ascórbico,
Estrés Oxidativo,
Esmalte Dental
Luiz, Rafael da Silva;
Rampaso, Rodolfo Rosseto;
Santos, Alef Aragão Carneiro dos;
Convento, Marcia Bastos;
Barbosa, Dulce Aparecida;
Fonseca, Cassiane Dezoti da;
Oliveira, Andréia Silva de;
Caires, Agnaldo;
Furlan, Andrei;
Schor, Nestor;
Borges, Fernanda Teixeira.
Background: The efficacy of bone marrow mesenchymal stromal cells (BM-MSC) and its extracellular vesicles has been demonstrated for a broad spectrum of indications, including kidney diseases. However, BM-MSC donor characteristics and their potential are not usually considered. Therefore, the present work...
OBJECTIVES: To investigate the molecular mechanism of edaravone (EDA) in improving the post-traumatic brain injury (TBI) dysfunction in learning and memory. METHODS: In vitro and in vivo TBI models were established using hydrogen peroxide (H2O2) treatment for hippocampal nerve stem cells (NSCs) and surg...
Elementos de Respuesta Antioxidante,
Apoptosis/efectos de los fármacos,
Lesiones Traumáticas del Encéfalo/tratamiento farmacológico,
Lesiones Traumáticas del Encéfalo/metabolismo,
Lesiones Traumáticas del Encéfalo/fisiopatología,
Edaravona/farmacología,
Aprendizaje/efectos de los fármacos,
Memoria/efectos de los fármacos,
Factor 2 Relacionado con NF-E2/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Especies Reactivas de Oxígeno/metabolismo,
Transducción de Señal/efectos de los fármacos
Los derivados de juglona, como 2-(4-hidroxifenil) amino-1,4-naftoquinona (Q7), son conocidos agentes antitumorales. Ellos generan especies reactivas de oxígeno (ROS), que podrían producir un desbalance de ROS y un metabolismo anormal de lípidos. El objetivo del estudio fue evaluar el efecto del ascorb...
Phosphodiesterase-5 inhibitors (PDE-5Is) exert positive effects on bone healing and mineralization by activation the nitric oxide/cyclic guanosine monophosphate/protein kinase-G (NO/cGMP/PKG) signaling pathway. In this study, the effects of zaprinast and avanafil, two PDE-5Is, on the NO signaling pathway...
OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is an important clinical problem that can be aggravated by diabetes mellitus, a major risk factor. However, heme oxygenase-1 (HO-1), a promising therapeutic target, can exert antioxidant effects against CI-AKI. Thus, we investigated the role of HO...
de Camargo, Anderson Alves;
de Castro, Rejane Agnelo Silva;
Vieira, Rodolfo P.;
Oliveira-Júnior, Manoel Carneiro;
Araujo, Amanda Aparecida de;
De Angelis, Kátia;
Rached, Samia Zahi;
Athanazio, Rodrigo Abensur;
Stelmach, Rafael;
Corso, Simone Dal.
OBJECTIVES: To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity. METHODS: This study used a cross-sectional design. Seventy-four adults with bronchiecta...
ABSTRACT Purpose: Subarachnoid hemorrhage (SAH) is a common complication of cerebral vascular disease. Hydrogen has been reported to alleviate early brain injury (EBI) through oxidative stress injury, reactive oxygen species (ROS), and autophagy. Autophagy is a programmed cell death mechanism that plays...
