Results: 185

Toxicidade do peróxido de carbamida 16% adicionado de nanopartículas de hidroxiapatita

O clareamento dental é um dos tratamentos mais realizados nos consultórios odontológicos a fim de melhorar a aparência do sorriso. O procedimento consiste na aplicação de um gel clareador, a base de peróxido de carbamida ou de hidrogênio, sobre os dentes a serem clareados. A sensibilidade dentár...

Estudio exploratorio II: identificación de nanopartículas en procesos industriales de soldadura y de minería

Cienc. Trab; 18 (55), 2016
Se realizó un estudio exploratorio sobre la exposición laboral a nanopartículas en procesos de empresas del sector minero, fundición y soldadura. Para evaluar la exposición se utilizó un método cualitativo simplificado y un método semi-cuantitativo basado en las técnicas tradicionales de higiene...

Cobalt oxide nanoparticles aggravate DNA damage and cell death in eggplant via mitochondrial swelling and NO signaling pathway

Biol. Res; 49 (), 2016
BACKGROUND: Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity in several organisms. In this study, we have investigated the role of Co3O4-NPs ...

Effects and molecular mechanism of chitosan-coated levodopa nanoliposomes on behavior of dyskinesia rats

Biol. Res; 49 (), 2016
BACKGROUND: Chitosan, the N-deacetylated derivative of chitin, is a cationic polyelectrolyte due to the presence of amino groups, one of the few occurring in nature. The use of chitosan in protein and drug delivery systems is being actively researched and reported in the literature RESULTS: In this study...

Desenvolvimento, avaliação da segurança e eficácia clínica de sistemas nanoparticulados de gelatina contendo rutina

A associação de filtros solares a compostos bioativos tem sido estudada com ênfase na última década. Contudo, a solubilidade limitada dos compostos naturais, tais como a rutina, restringe o desenvolvimento de preparações cosméticas seguras, funcionais e estáveis. A proposta deste estudo envolveu...

Freeze-drying of ampicillin solid lipid nanoparticles using mannitol as cryoprotectant

Braz. j. pharm. sci; 51 (4), 2015
abstract Solid lipid nanoparticles (SLNs) are interesting colloidal drug-delivery systems, since they have all the advantages of the lipid and polymeric nanoparticles. Freeze-drying is a widely used process for improving the stability of SLNs. Cryoprotectants have been used to decrease SLN aggregations d...

Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions

Braz. j. pharm. sci; 51 (4), 2015
abstract A simple stability-indicating RP-HPLC/UV method was validated for determination of beclomethasone dipropionate (BD) in nanocapsule suspensions. Chromatographic conditions consisted of a RP C18column (250 mm x 4.60 mm, 5 µm, 110 Å), using methanol and water (85:15 v/v) as mobile phase at 1.0 mL...

Validation of high performance liquid chromatography method for determination of meloxicam loaded PEGylated nanocapsules

Braz. j. pharm. sci; 51 (4), 2015
abstract A method to ensure that an analytical method will produce reliable and interpretable information about the sample must first be validated, making sure that the results can be trusted and traced. In this study, we propose to validate an analytical high performance liquid chromatography (HPLC) met...

Effects of a transdermal testosterone metered-dose nanoemulsion in peri- and postmenopausal women: a novel protocol for treating low libido

OBJECTIVE: To investigate the efficacy of a transdermal nanoemulsion testosterone associated with transdermal estrogen therapy as a novel protocol treatment for emergent loss of libido. METHODS: Twenty-four women, aged 31-75 years (mean age, 51.7), with emergent loss of libido were allocated to treatment...

Desenvolvimento de nanopartículas de poli (n-butil-cianoacrilato) com zidovudina revestidas por ácido hialurônico para veiculação em gel de uso transdérmico

A zidovudina (AZT) ainda é o fármaco mais empregado no tratamento da AIDS, isoladamente ou em associação a outros antirretrovirais, porém é um fármaco administrado em altas doses e que apresenta efeitos adversos que comprometem a adesão do paciente ao tratamento. Assim, um novo sistema de libera...