Abstract Thymoquinone (TQ) has shown hepatoprotective effects in various experimental studies. We aimed to investigate the possible beneficial effects of TQ regarding its prevention of alpha-amanitin induced hepatotoxicity in human C3A hepatocytes. After administering alpha-amanitin in a concentrations o...
Abstract Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro prolif...
Abstract Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions. Many dissolution media described in pharmacopoeias are no...
Abstract Bioequivalence (BE) assessment of topical drug products is a long-standing challenge. Agencies such as the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have published several drafts in recent years suggesting different approaches as alternative to evaluate the BE. A...
In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The der...
Abstract The main aim of the study is to quantify the cytotoxic property of the Fucoidan extracted from the Turbinaria conoides using the MTT assay with the standard fucose. Fucoidan was extracted using the soaked water method and it was determined using the HPLC procedure the obtained Test sample Fucoid...
Técnicas In Vitro/instrumentación,
Células MCF-7,
Células A549,
Citotoxinas/efectos adversos,
Cromatografía Líquida de Alta Presión/métodos,
Concentración 50 Inhibidora,
Fibroblastos/clasificación,
Fucosa/análogos & derivados,
Línea Celular,
Neoplasias Pulmonares/patología,
Neoplasias de la Mama/patología
In this study, a dichloromethane fraction dry extract from the underground parts of Jatropha isabellei (DFJi) was used to prepare lipid nanocarriers (LNCJi) aimed at providing the oral delivery of terpenic compounds in the treatment of arthritis. The lipid nanocarriers were prepared by the spontaneous em...
Abstract Design of experiment (DoE) is a useful time and cost-effective tool for analyzing the effect of independent variables on the formulation characteristics. The aim of this study is to evaluate the effect of the process variables on the characteristics involved in the preparation of Diclofenac Sodi...
Nanopartículas/análisis,
Optimización de Procesos,
Análisis de Fourier,
Costos y Análisis de Costo/métodos,
Diclofenaco/análisis,
Espectroscopía Infrarroja por Transformada de Fourier,
Metodología como un Tema,
Microscopía Electrónica de Rastreo/métodos,
Preparaciones Farmacéuticas,
Técnicas In Vitro/instrumentación,
Rastreo Diferencial de Calorimetría/instrumentación
Abstract In an attempt to increase molecular stability and provide controlled release, vascular endothelial growth factor (VEGF) was encapsulated into polycaprolactone (PCL) nanoparticles. Both VEGF-free and VEGF-loaded PCL nanoparticles were formulated by w/o/w double emulsion of the dichloromethane-wat...
Abstract Posaconazole exerts an extended spectrum of antifungal activity against various strains of clinically relevant moulds and yeasts. In recent years, antifungal triazole posaconazole has become increasingly important for the prophylaxis and treatment of systemic mycoses. After oral administration o...
Disolución,
Administración Oral,
Cristalización/instrumentación,
Disponibilidad Biológica,
Eficiencia,
Espectroscopía Infrarroja por Transformada de Fourier,
Esguinces y Distensiones/diagnóstico,
Levaduras/clasificación,
Micosis/patología,
Preparaciones Farmacéuticas,
Técnicas In Vitro/métodos,
Ácido Clorhídrico
