Alves, Silvia Marinho Martins;
Alvarado-Arnês, Lúcia Elena;
Cavalcanti, Maria da Glória Aureliano de Melo;
Carrazzone, Cristina de Fátima Velloso;
Pacheco, Antônio Guilherme Fonseca;
Sarteschi, Camila;
Moraes, Milton Ozorio;
Oliveira Junior, Wilson Alves de;
Medeiros, Carolina de Araújo;
Pessoa, Fernanda Gallinaro;
Mady, Charles;
Lannes-Vieira, Joseli;
Ramires, Felix José Alvarez.
Abstract INTRODUCTION: Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi. One-third of infected patients will develop the cardiac form, which may progress to heart failure (HF). However, the factors that determine disease progression remain unclear. Increased angiotens...
Inhibidores de la Enzima Convertidora de Angiotensina,
Brasil,
Estudios de Casos y Controles,
Enfermedad de Chagas/genética,
Enfermedad de Chagas/fisiopatología,
Estudios de Cohortes,
Progresión de la Enfermedad,
Genotipo,
Insuficiencia Cardíaca/genética,
Insuficiencia Cardíaca/fisiopatología,
Persona de Mediana Edad,
Peptidil-Dipeptidasa A/genética,
Polimorfismo Genético/genética
Abstract INTRODUCTION: The human T-lymphotropic virus type 1 (HTLV-1) has a single-stranded RNA genome and expresses specific proteins that have oncogenic potential. Approximately 15 to 20 million people worldwide have been infected by this virus. Changes in protein or gene expression are the effects of...
Donantes de Sangre/estadística & datos numéricos,
Estudios de Casos y Controles,
Predisposición Genética a la Enfermedad,
Genotipo,
Infecciones por HTLV-I/diagnóstico,
Infecciones por HTLV-I/genética,
Virus Linfotrópico T Tipo 1 Humano/genética,
Persona de Mediana Edad,
Polimorfismo de Nucleótido Simple/genética,
Receptor Toll-Like 3/genética,
Irán
Abstract INTRODUCTION We conducted a cost-utility analysis of available interferon-free treatments for patients with early-stage genotype 1 chronic hepatitis C based on a Brazilian public health system perspective. METHODS A Markov model was derived using a cohort of stage F0-F2 patients treated as r...
Abstract INTRODUCTION: The average annual incidence of cryptococcosis in Colombia is 0.23 cases per 100,000 inhabitants in the general population, and 1.1 cases per 1000 in inhabitants with Acquired Immune Deficiency Syndrome (AIDS). In addition, the causal fungus has been isolated from the environment,...
de Jesus, Jaqueline Goes;
Dutra, Karina Rocha;
Sales, Flavia Cristina da Silva;
Claro, Ingra Morales;
Terzian, Ana Carolina;
Candido, Darlan da Silva;
Hill, Sarah C;
Thézé, Julien;
Torres, Celeste;
DAgostini, Tatiana Lang;
Felix, Alvina Clara;
Reis, Andreia F Negri;
Alcantara, Luiz Carlos Junior;
de Abreu, André L;
Croda, Júlio HR;
de Oliveira, Wanderson K;
de Filipis, Ana Maria Bispo;
Camis, Maria do Carmo Rodrigues dos Santos;
Romano, Camila Malta;
Loman, Nick J;
Pybus, Oliver G;
Sabino, Ester Cerdeira;
Nogueira, Mauricio L;
Faria, Nuno Rodrigues.
BACKGROUND Despite efforts to mitigate the impact of dengue virus (DENV) epidemics, the virus remains a public health problem in tropical and subtropical regions around the world. Most DENV cases in the Americas between January and July 2019 were reported in Brazil. São Paulo State in the southeast of ...
We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD1...
Behavioral observations made on fish have revealed remarkably diverse reproductive strategies, including polygamy by both sexes. Still, to date, most Neotropical species remain unstudied as to whether the observed reproductive behavior in natural populations correlates with their genetic mating systems. ...
The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly popul...
Apolipoproteínas B/genética,
Aterosclerosis/sangre,
Aterosclerosis/genética,
Brasil,
Enfermedades Cardiovasculares/sangre,
Ingestión de Energía,
Conducta Alimentaria,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad/genética,
Genotipo,
Lípidos/sangre,
Polimorfismo Genético/genética,
Factores de Riesgo
RESUMO Objetivo Sumarizar fatores de risco e indicadores de mortalidade em pacientes com doença falciforme. Método Revisão integrativa em periódicos indexados nas bases de dados CINAHL, PubMed/MEDLINE, Science Direct/SCOPUS, SciELO e Web of Science. A questão norteadora foi elaborada por meio da e...
Genes associated with wound healing have been shown to be risk factors for cutaneous leishmaniasis (CL) which is caused by Leishmania braziliensis. In this study, we examined whether the genes previously associated with CL influenced the clinical outcome. Patients were genotyped and retrospectively class...
Antimonio/uso terapéutico,
Antiprotozoarios/uso terapéutico,
Estudios de Casos y Controles,
Predisposición Genética a la Enfermedad,
Genotipo,
Leishmaniasis Cutánea/tratamiento farmacológico,
Leishmaniasis Cutánea/genética,
Leishmaniasis Cutánea/patología,
Persona de Mediana Edad,
Polimorfismo de Nucleótido Simple,
Estudios Retrospectivos,
Pruebas Cutáneas,
Cicatrización de Heridas/genética
