Results: 354

Tuberculosis anal como diagnóstico diferencial de lesión ulcerada anal
Anal tuberculosis as a differential diagnosis of ulcerated anal lesion

La tuberculosis (TBC) es una enfermedad infecciosa crónica, granulomatosa, transmisible, producida por el microorganismo Mycobacterium tuberculosis o bacilo de Koch. Puede presentarse como enfermedad pulmonar, extrapulmonar o ambas. La presentación extrapulmonar, es rara, representando aproximadamente ...

Resistencia a medicamentos en mycobacterium tuberculosis: contribución de mecanismos constitutivos y adquiridos

Rev. salud pública; 20 (4), 2018
RESUMEN En presencia de aislamientos de Mycobacterium tuberculosis (MTB) multifármaco-resistentes (MTB-MDR) y con resistencia extendida (MTB-XDR) las tasas de fracaso de los esquemas estandarizados de tratamiento son altas, constituyéndose en un verdadero problema de salud pública a nivel mundial. La ...

Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism

Braz. j. infect. dis; 22 (3), 2018
ABSTRACT Introduction Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ produc...

Performance of the IS6110-TaqMan® assay in the diagnosis of extrapulmonary tuberculosis from different biological samples

Abstract INTRODUCTION: This study evaluated the performance of the IS6110-TaqMan® assay in different types of biological samples and tissues for laboratory diagnosis of extrapulmonary tuberculosis. METHODS: 143 biological samples and tissues from patients with suspected extrapulmonary tuberculosis fro...

Lineamientos técnicos para el control de infecciones con énfasis en tuberculosis

La Tuberculosis es una enfermedad prevalente en varios países de las Américas, siendo El Salvador uno de ellos y su frecuencia a nivel comunitario generalmente traslada los riesgos de transmisión del Mycobacterium tuberculosis al interior de los establecimientos de salud. Esto también ocurre en grupo...

The role of the Xpert MTB/RIF assay among adolescents suspected of pulmonary tuberculosis in Rio de Janeiro, Brazil

Abstract INTRODUCTION The teste rápido molecular para tuberculose (TRM-TB) was introduced in 2014 in Brazil for tuberculosis screening. However, its role in adolescents in Brazil has not been studied. METHODS A descriptive study of adolescents with suspected tuberculosis using National Laboratory so...

Microscopic detection of Mycobacterium tuberculosis in direct or processed sputum smears

Abstract INTRODUCTION: Microscopic identification of active pulmonary tuberculosis (PTB) from direct smears of sputum (DS) is widely used for detection, but has limited sensitivity. Here, we assessed the yield of acid-fast bacilli (AFB) detection in processed sputum smears (PSS). METHODS: Sputum samp...

Impact of smoking on sputum culture conversion and pulmonary tuberculosis treatment outcomes in Brazil: a retrospective cohort study

J. bras. pneumol; 44 (2), 2018
ABSTRACT Objective: To evaluate the impact of smoking on pulmonary tuberculosis (PTB) treatment outcomes and the two-month conversion rates for Mycobacterium tuberculosis sputum cultures among patients with culture-confirmed PTB in an area with a moderate incidence of tuberculosis in Brazil. Methods: T...

Rapid molecular test for tuberculosis: impact of its routine use at a referral hospital

J. bras. pneumol; 44 (2), 2018
ABSTRACT Objective: To evaluate the impact of the use of the molecular test for Mycobacterium tuberculosis and its resistance to rifampin (Xpert MTB/RIF), under routine conditions, at a referral hospital in the Brazilian state of Bahia. Methods: This was a descriptive study using the database of the My...

Mycobacterium tuberculosis promotes genomic instability in macrophages

Mem. Inst. Oswaldo Cruz; 113 (3), 2018
BACKGROUND Mycobacterium tuberculosis is an intracellular pathogen, which may either block cellular defensive mechanisms and survive inside the host cell or induce cell death. Several studies are still exploring the mechanisms involved in these processes. OBJECTIVES To evaluate the genomic instability o...