Hydroxymethylnitrofurazone (NFOH) is a new compound with potential leishmanicidal and trypanocidal activity. Despite its effectiveness, the formulators have to overcome its poor aqueous solubility. Recently, polymeric nano-scale drug delivery systems have proposed for the treatment of neglected diseases....
Los nanomateriales pueden tener diferentes propiedades a las del mismo material en mayor escala. Esto permite el uso en diversas ramas de la producción, con un papel especial en la industria de la salud, como en sensores para el diagnóstico y recubrimiento de fármacos para drug delivery. Diferentes pr...
Segundo a Organização Mundial de Saúde, a hipertensão arterial é responsável por uma crise global de saúde pública, sendo as doenças cardiovasculares implicadas em aproximadamente 17 milhões de mortes/ano, das quais, 9,4 milhões ocasionadas por complicações provocadas pela hipertensão, como...
Poly (L-lactic acid) (PLA) nanoparticles have the approval of the main institutions for drugs administration and therapeutics. However, the use of lactic acid polymer is controversial because lactic acid has been proposed as an energy source for cancer cells. The aim of this study was to evaluate the cyt...
Neoplasias Gástricas,
Adenocarcinoma,
Antineoplásicos/administración & dosificación,
Polímeros,
Ácido Láctico,
Neoplasias Gástricas/patología,
Adenocarcinoma/patología,
Línea Celular Tumoral/efectos de los fármacos,
Supervivencia Celular,
Sulfato de Cobre,
Microscopía Electrónica de Transmisión,
Nanopartículas,
Emulsiones,
Apoptosis
The main objective of the present study was to determine the permeability of clarithromycin (CLA)-PLGA nanoparticles using single-pass intestinal perfusion technique in rats. Clarithromycin nanoparticles were prepared by nano-precipitation according to the modified quasi emulsion solvent diffusion techni...
The scientific community and general public have been exposed to a series of achievements attributed to a new area of knowledge: Nanotechnology. Both abroad and in Brazil, funding agencies have launched programs aimed at encouraging this type of research. Indeed, for many who come into contact with this ...
A adição de nanopartículas aos materiais odontológicos busca melhorar principalmente suas propriedades antibacterianas sem, contudo, alterar suas propriedades mecânicas e físicas. O objetivo deste estudo foi avaliar a influência da incorporação de nanopartículas de dióxido de titânio (TiO2) a...
The objective of the research was to formulate and evaluate selegiline hydrochloride loaded chitosan nanoparticles for the Parkinson's therapy in order to improve its therapeutic effect and reducing dosing frequency. Taguchi method of design of experiments (L9 orthogonal array) was used to get optimized ...
In this work, we developed and validated an effective reversed-phase HPLC method with photodiode array (PDA) detection for the quantitative analysis of amphotericin B (AmB) in poly(lactide)-poly(ethylene glycol) (PLA-PEG) blend nanoparticles. Chromatographic runs were performed on a reverse phase C18 col...
Se realizó un estudio exploratorio con los objetivos de identificar empresas que produzcan o manipulen nanopartículas en Chile, evaluar los riesgos para la salud de estas actividades y entregar recomendaciones para su control. Se encontró que la nanotecnología está en una etapa incipiente, con un re...
Nanopartículas/toxicidad,
Enfermedades Profesionales/prevención & control,
Exposición Profesional/prevención & control,
Riesgos Laborales,
Índice de Severidad de la Enfermedad,
Investigación Cualitativa,
Chile,
Salud Laboral,
Material Particulado/toxicidad,
Medición de Riesgo,
Nanopartículas/ultraestructura,
Microscopía Electrónica
