Santos-Júnior, Luciano;
Oliveira, Tassia Virgínia de Carvalho;
Cândido, Janaína Farias;
Santana, Danielle Souza de;
Pereira Filho, Rose Nely;
Pereyra, Beatriz Benny Sungaila;
Gomes, Margarete Zanardo;
Lima, Sônia Oliveira;
Albuquerque-Júnior, Ricardo Luiz Cavalcanti de;
Cândido, Edna Aragão Farias.
Abstract Purpose: To investigate the cellular response to injury, analyzing histopathologic changes associated with increased cellularity, degeneration and disorganization of collagen fibers. Methods: Thirty wistar rats were divided in two groups after partial Achilles tenotomy: the right hind paw were...
Abstract Purpose: To investigate the effects of dexmedetomidine (DEX) on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury (I/R). Methods: Thirty-six, male, Wistar rats were randomly divided into three groups: the sham operation group (group C), the i...
Aminoácidos/efectos de los fármacos,
Aminoácidos/metabolismo,
Isquemia Encefálica/tratamiento farmacológico,
Isquemia Encefálica/metabolismo,
Corteza Cerebral/química,
Corteza Cerebral/ultraestructura,
Dexmedetomidina/farmacología,
Glutamina/metabolismo,
Fármacos Neuroprotectores/farmacología,
Ratas Wistar,
Daño por Reperfusión/metabolismo,
Ácido gamma-Aminobutírico/efectos de los fármacos,
Ácido gamma-Aminobutírico/metabolismo
ABSTRACT The constant use of chemical insecticides for Aedes aegypti control has caused resistance in the mosquito populations. Thus, the objective of this study was to analyze the larvicidal potential of extracts and fractions of plants on A. aegypti larvae. The analysis included sixty one extracts and ...
Aedes,
Bioensayo,
Agentes de Control Biológico,
Brasil,
Etanol/química,
Insecticidas,
Larva,
Extractos Vegetales,
Hojas de la Planta/química,
Valores de Referencia,
Reproducibilidad de los Resultados,
Pruebas de Toxicidad
TIETBOHL, LUIS A C;
OLIVEIRA, ADRIANA P;
ESTEVES, RICARDO S;
ALBUQUERQUE, RICARDO D D G;
FOLLY, DIOGO;
MACHADO, FRANCISCO P;
CORRÊA, ARTHUR L;
SANTOS, MARCELO G;
RUIZ, ANA L G;
ROCHA, LEANDRO.
ABSTRACT Myrciaria floribunda (H. West ex Willd.) O. Berg, Myrtaceae, is a native plant species of the Atlantic Rain Forest, from north to south of Brazil. The lyophilized ethyl acetate extract from the leaves of M. floribunda was investigated for its antiproliferative activity in tumor cell lines, antio...
Acetatos/química,
Acetatos/farmacología,
Antioxidantes/farmacología,
Compuestos de Bifenilo,
Brasil,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Flavonoides/análisis,
Indicadores y Reactivos,
Myrtaceae/química,
Capacidad de Absorbancia de Radicales de Oxígeno,
Fenoles/análisis,
Picratos
ABSTRACT Viruá National Park encompasses a vast and complex system of hydromorphic sandy soils covered largely by the white sand vegetation ("Campinarana") ecosystem. The purpose of this study was to investigate a vegetation gradient of "terra-firme"-white sand vegetation at the Viruá National Park. Ni...
ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= ...
Anomalías Inducidas por Medicamentos,
Ascomicetos/química,
Benzofuranos/química,
Benzofuranos/toxicidad,
Peso Fetal/efectos de los fármacos,
Feto/efectos de los fármacos,
Hepatocitos/efectos de los fármacos,
Ácido Láctico/química,
Ácido Láctico/toxicidad,
Líquenes/química,
Hígado/efectos de los fármacos,
Hígado/patología,
Exposición Materna,
Ácido Poliglicólico/química,
Ácido Poliglicólico/toxicidad,
Copolímero de Ácido Poliláctico-Ácido Poliglicólico,
Distribución Aleatoria,
Ratas Wistar,
Valores de Referencia
ABSTRACT The objective of this study was to compare the estimates of ether extract (EE) contents obtained by the Randall method and by the high-temperature method of the American Oil Chemist's Society (AOCS; Am 5-04) in forages (n = 20) and cattle feces (n = 15). The EE contents were quantified by using ...
ABSTRACT This study aims to identify special metabolites in polar extracts from Urochloa humidicola (synonym Brachiaria humidicola) that have allelopathic effects and induce secondary photosensitization in ruminants. The compounds were isolated and identified via chromatographic and spectroscopic techniq...
Brachiaria/química,
Cromatografía en Capa Delgada,
Crotonatos/química,
Crotonatos/aislamiento & purificación,
Flavonoides/química,
Flavonoides/aislamiento & purificación,
Glicósidos/química,
Glicósidos/aislamiento & purificación,
Espectroscopía de Resonancia Magnética,
Estructura Molecular,
Parabenos/química,
Parabenos/aislamiento & purificación,
Extractos Vegetales/química,
Saponinas/química,
Ácido Vanílico/química
ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids...
Línea Celular Tumoral,
Supervivencia Celular/efectos de los fármacos,
Inhibidores de la Colinesterasa,
Colorimetría,
Ensayo de Inmunoadsorción Enzimática,
Espectroscopía de Resonancia Magnética,
N,N-Dimetiltriptamina/química,
Extractos Vegetales/química,
Extractos Vegetales/aislamiento & purificación,
Extractos Vegetales/farmacología,
Hojas de la Planta/química,
Psychotria/química,
Reproducibilidad de los Resultados,
Espectroscopía Infrarroja por Transformada de Fourier
BISPO, VANDERSON S;
DANTAS, LUCAS S;
CHAVES FILHO, ADRIANO B;
PINTO, ISABELLA F D;
SILVA, RAILMARA P DA;
OTSUKA, FELIPE A M;
SANTOS, RODRIGO B;
SANTOS, ALINE C;
TRINDADE, DANIELLE J;
MATOS, HUMBERTO R.
ABSTRACT Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLC-ESI+-MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective ...
Antioxidantes/farmacología,
Ácido Ascórbico/farmacología,
Ácidos Cafeicos/farmacología,
Colesterol/sangre,
Cocos/química,
Daño del ADN/efectos de los fármacos,
Etanol/farmacología,
Peroxidación de Lípido,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar,
Reproducibilidad de los Resultados,
Espectrometría de Masas en Tándem,
Sustancias Reactivas al Ácido Tiobarbitúrico,
Factores de Tiempo,
Triglicéridos/sangre,
Agua/farmacología
