Results: 467

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor

Biol. Res; 53 (), 2020
BACKGROUND: Gallbladder cancer (GBC) is the most common tumor of the biliary tract. The incidence of GBC shows a large geographic variability, being particularly frequent in Native American populations. In Chile, GBC represents the second cause of cancer-related death among women. We describe here the es...

Puerarin inhibits hepatocellular carcinoma invasion and metastasis through miR-21-mediated PTEN/AKT signaling to suppress the epithelial-mesenchymal transition

Braz. j. med. biol. res; 53 (4), 2020
Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors of the liver worldwide. Liver resection and transplantation are currently the only effective treatments; however, recurrence and metastasis rates are still high. Previous studies have shown that the epithelial-mesenchymal t...

Effect of cryotherapy in preventing mucositis associated with the use of 5-fluorouracil

Objective: to evaluate the effect of oral cryotherapy compared to physiological serum on the development of oral mucositis in outpatient cancer patients using the 5-fluorouracil antineoplastic agent. Method: this is a controlled, randomized, double-blind, and multi-center clinical trial, conducted with ...

Differences between the oral changes presented by patients with solid and hematologic tumors during the chemotherapeutic treatment

J. appl. oral sci; 28 (), 2020
Abstract Objective: This study sought to identify the differences between the oral changes presented by patients with solid and hematologic tumors during chemotherapeutic treatment. Methodology: This is an observational, prospective and quantitative study using direct documentation by follow-up of 105 ...

Neuroendocrine tumor in a child with common variable immunodeficiency

ABSTRACT Objective: To report a case of a child with primary immunodeficiency who at eight years developed digestive symptoms, culminating with the diagnosis of a neuroendocrine tumor at ten years of age. Case description: One-year-old boy began to present recurrent pneumonias in different pulmonary ...

Construção e avaliação de bundle frente ao extravasamento de antineoplásicos: estudo metodológico

Resumo Objetivo Construir e avaliar o conteúdo de um bundle de prevenção e condutas frente ao extravasamento de agentes antineoplásicos em pacientes oncológicos adultos. Métodos Estudo metodológico, em três etapas: realização de Scoping Review, construção do bundle e avaliação do materi...

Development, in vitro biocompatibility, and antitumor efficacy of acetic acid-modified Cordyceps sinensis polysaccharide nanoparticle drug delivery system

Docetaxel-loaded acetic acid conjugated Cordyceps sinensis polysaccharide (DTX-AA-CSP) nanoparticles were prepared through dialysis and their release rates in vitro, particle sizes, zeta potentials, drug loading capacities, and encapsulation efficiencies were characterized for the synthesis of AA-modifie...

Perfil de utilização de medicamentos antineoplásicos entre indígenas atendidos pelo Sistema Único de Saúde

Resumo: Estima-se que no Brasil existam cerca de 900 mil indígenas (0,4% da população do país) pertencentes a mais de 300 etnias diferentes. Porém, informações sobre a epidemiologia do câncer e sobre os medicamentos antineoplásicos utilizados no tratamento desses indivíduos são escassas. Os ob...

Cascos fríos para la prevención de alopecia inducida por quimioterápicos
Cold caps for the prevention of chemotherapy-induced alopecia

Uno de los efectos adversos que generan mayor impacto psicosocial en los pacientes que se someten a quimioterapia es la pérdida de cabello. El uso de los cascos fríos podría representar una alternativa para prevenir la alopecia. Estos dispositivos producen vasoconstricción en los vasos sanguíneos de...

In vitro Studies of Antitumor Activity of Vanadium Complexes with Orotic and Glutamic Acids

Rev. bras. cancerol; 66 (1), 2020
Introduction: Three vanadium complexes with orotic and glutamic acids, in their anion forms, were prepared and their in vitro cytotoxicity toward human lung fibroblasts (MRC-5), human hepatocellular carcinoma (HepG2) and human colorectal adenocarcinoma (Caco-2) are reported. Objective: Describe the synth...