Background Solitary wasp venoms may be a rich source of neuroactive substances, since their venoms are used for paralyzing preys. We have been exploring bioactive constituents of solitary wasp venoms and, in this study, the component profile of the venom from a solitary scoliid wasp, Scolia decorata vent...
Medeiros, Scheila;
Maia, Thayná Patachini;
Lima, Aline Barbosa;
Pscheidt, Luana Carla;
Delmonego, Larissa;
Vincenzi, Karine Louize;
Custodio, Bruna Vanzin;
Dal Magro, Débora Delwing;
Barauna, Sara Cristiane;
Alberton, Michele Debiasi;
Pereira, Eduardo Manoel;
Delwing-de Lima, Daniela.
We investigated the effects of dichloromethane extract (DME) from Myrcia splendenson alterations caused by type 2 diabetes in the blood and kidney of rats, in order to reduce side effects caused by synthetic drugs. Rats received streptozotocin (60 mg/kg),15 minutes after nicotinamide (120 mg/kg) or water...
Myrtaceae/química,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Extractos Vegetales/administración & dosificación,
Cloruro de Metileno/administración & dosificación,
Hipolipemiantes/administración & dosificación,
Hipoglucemiantes/administración & dosificación,
Antioxidantes/administración & dosificación,
Extractos Vegetales/química,
Compuestos Fenólicos/análisis,
Estrés Oxidativo/efectos de los fármacos,
Cromatografía Líquida de Alta Presión,
Espectrometría de Masa por Ionización de Electrospray,
Ratas Wistar,
Glucemia/efectos de los fármacos,
Estreptozocina
Marchetti, Desirèe;
Ribas, Graziela;
Donida, Bruna;
Brito, Verônica;
Moura, Dinara;
Coelho, Daniella;
Machado, Andryele;
Kessler, Rejane;
Coitinho, Adriana;
Vargas, Carmen.
Introduction: Several studies in the literature have evaluated the role of oxidative stress and adjuvant therapies for X-linked adrenoleukodystrophy (X-ALD). Here, we investigated whether n-acetyl-L-cysteine (NAC) and rosuvastatin (RSV) could influence the generation of reactive species, redox status and...
Abstract Objective The exposure to mercury (Hg) from dental amalgams is a suspected causative factor in neurological diseases. This study investigated the toxic effects of two different amalgam compositions related to Hg and the protective effects of selenium against the toxic effects of Hg through the...
Abstract This study aimed to evaluate the toxic impact of hydro-alcoholic Allium jesdianum extract (AJE) on the growth of HT-29 human colorectal cancer cell line. Phytochemical analysis using gas chromatography and mass spectroscopy (GCMS) was done to determine the bioactive components of AJE. HT-29 cell...
Hartmann, D D;
Martins, R P;
Silva, T C da;
Stefanello, S T;
Courtes, A A;
Gonçalves, D F;
Furtado, A B V;
Duarte, B S L;
Signori, L U;
Soares, F A A;
Puntel, G O.
The skin injury healing process involves the main phases of homoeostasis, inflammation, proliferation, and remodeling. The present study aimed to analyze the effects of low-level laser therapy (LLLT) on hematological dynamics, oxidative stress markers, and its relation with tissue healing following skin ...
Sun, Y D;
Gao, Y S;
Xu, L W;
Zhang, Y F;
Cheng, C;
Wei, K C;
Lin, Jian;
Chen, G;
Liu, C Y;
Li, Q F.
Ischemia-reperfusion injury (IRI) has brought attention to flap failure in reconstructive surgery. To improve the prognosis of skin transplantation, we performed experimental IRI by surgical obstruction of blood flow and used sodium ferulate (SF) to prevent IRI in rats. After SF treatment, the morphologi...
The study evaluated the effect of the supernatant of placental explants from preeclamptic (PE) and normotensive (NT) pregnant women after tissue treatment with or without vitamin D (VD) on oxidative stress and nitric oxide (NO) bioavailability in human umbilical vein endothelial cells (HUVEC). Placental ...
Bedir, F;
Kocaturk, H;
Turangezli, O;
Sener, E;
Akyuz, S;
Ozgeris, F B;
Dabanlioglu, B;
Suleyman, H;
Altuner, D;
Suleyman, B.
It is known that the combined use of antibiotics, such as isoniazid and rifampicin, in the treatment of tuberculosis causes oxidative kidney damage. The aim of this study was to biochemically and histopathologically investigate the effect of lycopene on oxidative kidney damage due to the administration o...
We explored the cascade effects of a high fat-carbohydrate diet (HFCD) and pioglitazone (an anti-diabetic therapy used to treat type 2 diabetes mellitus (T2DM)) on lipid profiles, oxidative stress/antioxidant, insulin, and inflammatory biomarkers in a rat model of insulin resistance. Sixty albino rats (8...
Antiinflamatorios/farmacología,
Antioxidantes/farmacología,
Carbohidratos/farmacología,
Diabetes Mellitus Tipo 2/tratamiento farmacológico,
Diabetes Mellitus Tipo 2/metabolismo,
Dieta Alta en Grasa,
Insulina/metabolismo,
Resistencia a la Insulina,
Hígado/metabolismo,
Estrés Oxidativo,
Pioglitazona/metabolismo,
Pioglitazona/farmacología
