Himatanthus drasticus (Mart.) Plumel belongs to the Apocynaceae family and the latex from its trunk bark (Hd) is known as "janaguba milk". This latex is widely used in Northeast Brazil, mainly in the Cariri region, for its gastroprotective, anti-inflammatory, and antitumor properties. The objective of th...
Analgésicos/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Apocynaceae/química,
Biomarcadores/sangre,
Modelos Animales de Enfermedad,
Edema/tratamiento farmacológico,
Inmunohistoquímica,
Inflamación/tratamiento farmacológico,
Ratas Wistar,
Triterpenos/aislamiento & purificación,
Triterpenos/uso terapéutico
Excessive pro-inflammatory cytokines result in adverse pregnancy outcomes, including preeclampsia-like phenotypes, and fetal growth restriction. Anti-inflammation might be an effective therapy. The aim of this research was to investigate whether Uncaria rhynchophylla alkaloid extract (URE), a highly safe...
Abstract: The study characterizes dental implant surfaces treated with phosphoric acid to assess the effects of acid treatment on blood cells and correlate them with cytokine levels. The implant surfaces examined were divided into untreated metal surface (US; n = 50), metal surface treated with phosphori...
Antiinflamatorios,
Supervivencia Celular,
Citocinas/análisis,
Citocinas/metabolismo,
Cementos Dentales,
Implantes Dentales,
Materiales Dentales/farmacología,
Interleucina-10/análisis,
Interleucina-10/metabolismo,
Leucocitos Mononucleares/efectos de los fármacos,
Microscopía Electrónica de Rastreo,
Ácidos Fosfóricos/farmacología,
Reología,
Propiedades de Superficie
Abstract: Eugenia dysenterica is a Brazilian tree investigated for its properties and bioactive compounds, which are believed to have both pharmacological and phytochemical therapeutic effects. The leaves of this tree contain tannins, flavonoids, terpenes, and saponins, with reportedly beneficial effects...
Antiinflamatorios/farmacología,
Antioxidantes/farmacología,
Brasil,
Células Cultivadas,
Clorhexidina/análogos & derivados,
Clorhexidina/farmacología,
Eugenia/química,
Fibroblastos/efectos de los fármacos,
Encía/química,
Óxido Nítrico/análisis,
Extractos Vegetales/farmacología,
Hojas de la Planta/química,
Células RAW 264.7,
Valores de Referencia,
Reproducibilidad de los Resultados,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo,
Cicatrización de Heridas/efectos de los fármacos
Abstract Colchicine is widely used in the treatment of several inflammatory diseases due to its anti-inflammatory effect, but effects on bone metabolism are unclear. The aim of this study was to evaluate the effects of systemically-administered colchicine on healthy periodontium and experimentally-induce...
Pérdida de Hueso Alveolar/tratamiento farmacológico,
Pérdida de Hueso Alveolar/patología,
Antiinflamatorios/farmacología,
Antiinflamatorios/uso terapéutico,
Colchicina/farmacología,
Colchicina/uso terapéutico,
Inmunohistoquímica,
Ligadura,
Metaloproteinasa 1 de la Matriz/análisis,
Osteoblastos/efectos de los fármacos,
Osteoclastos/efectos de los fármacos,
Periodontitis/tratamiento farmacológico,
Periodontitis/etiología,
Periodontitis/patología,
Ratas Wistar,
Reproducibilidad de los Resultados,
Fosfatasa Ácida Tartratorresistente/análisis,
Factores de Tiempo,
Resultado del Tratamiento,
Moduladores de Tubulina/farmacología
Abstract Purpose: To investigate the influence of lycium barbarum polysaccharides (LBP), a functional derivative from lycium barbarum, on septic kidney injury. Methods: The SD male rats were randomly divided into 8 groups. The concentration of IL-1β, IL-6, IL-8, TNF-α, NF-κB and ROS, in...
Abstract Purpose To examine the therapeutic effect of external adenosine on an acetic acid-induced acute ulcerative colitis model in rats. Methods Thirty male mature rats were divided into three groups as control, acute colitis (AC) and AC+adenosine group (AC+AD). AC was induced by rectal administrat...
Ácido Acético,
Enfermedad Aguda,
Adenosina/uso terapéutico,
Antiinflamatorios/uso terapéutico,
Proteína C-Reactiva/análisis,
Colitis Ulcerosa/inducido químicamente,
Colitis Ulcerosa/tratamiento farmacológico,
Colitis Ulcerosa/patología,
Colon/patología,
Ensayo de Inmunoadsorción Enzimática,
Inmunohistoquímica,
Malondialdehído/sangre,
FN-kappa B/análisis,
Ratas Sprague-Dawley,
Recto/patología,
Valores de Referencia,
Reproducibilidad de los Resultados,
Componente Amiloide P Sérico/análisis,
Sustancias Reactivas al Ácido Tiobarbitúrico,
Factores de Tiempo,
Resultado del Tratamiento,
Factor de Necrosis Tumoral alfa/análisis
ABSTRACT Background: Hypovolemic shock is a common disease in polytrauma patients and may develop ischemia in various organs, increasing morbidity and mortality. The bowel is usually most affected by this condition. Aim: To evaluate the effects of copaiba oil on the intestinal mucosa's injury of rats ...
Antiinflamatorios/química,
Antiinflamatorios/farmacología,
Antiinflamatorios/uso terapéutico,
Modelos Animales de Enfermedad,
Fabaceae/química,
Íleon/patología,
Mucosa Intestinal/efectos de los fármacos,
Mucosa Intestinal/patología,
Isquemia/tratamiento farmacológico,
Aceites de Plantas/química,
Aceites de Plantas/farmacología,
Aceites de Plantas/uso terapéutico,
Distribución Aleatoria,
Ratas Wistar,
Choque/tratamiento farmacológico
A mucosite oral (MO) é uma inflamação aguda da mucosa oral, sequela mais
importante dos tratamentos de radioterapia ou/e quimioterapia. As lesões na cavidade oral são
graves, dolorosas e podem levar a sepse e morte. Não existe um protocolo único de prevenção
e cura para MO. Na perspectiva de enc...
Abstract Purpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts. Methods: Wistar male rats (n = 30) were divided into 3 group...
Antiinflamatorios/uso terapéutico,
Antioxidantes/uso terapéutico,
Regeneración Ósea/efectos de los fármacos,
Trasplante Óseo,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Oseointegración/efectos de los fármacos,
Ratas Wistar,
Reishi/química,
Cráneo/efectos de los fármacos,
Cráneo/cirugía
