Results: 234

Avaliação da microdureza e do potencial antimicrobiano de cimentos para cimentação modificados com diacetato de clorexidina a 0, 5%

O objetivo deste estudo foi avaliar, in vitro, a microdureza e o potencial antimicrobiano de três cimentos para cimentação utilizados em dentística modificados com diacetato de clorexidina a 0,5%. Para o teste de exaustão foram usados 48 corpos de prova de 5 mm de diâmetro por 2 mm de altura, coloc...

Marcadores e mecanismos de resistência à terapia neoadjuvante e o papel das vesículas extracelulares secretadas pelas células tumorais no câncer de reto

O câncer de reto é o segundo tumor mais comum no intestino grosso correspondendo a um terço do total de casos de câncer colorretal (CCR). Pacientes com câncer de reto em estádios II e III são tratados com radioquimioterapia neoadjuvante seguida de ressecção cirúrgica do tumor. Análises das pe...

Homocysteine induces glyceraldehyde-3-phosphate dehydrogenase acetylation and apoptosis in the neuroblastoma cell line Neuro2a

Braz. j. med. biol. res; 49 (2), 2016
High plasma levels of homocysteine (Hcy) promote the progression of neurodegenerative diseases. However, the mechanism by which Hcy mediates neurotoxicity has not been elucidated. We observed that upon incubation with Hcy, the viability of a neuroblastoma cell line Neuro2a declined in a dose-dependent ma...

Cardioprotection against experimental myocardial ischemic injury using cornin

Braz. j. med. biol. res; 49 (2), 2016
Phosphorylated-cyclic adenosine monophosphate response element-binding protein (Phospho-CREB) has an important role in the pathogenesis of myocardial ischemia. We isolated the iridoid glycoside cornin from the fruit of Verbena officinalis L, investigated its effects against myocardial ischemia and reperf...

Rescuing axons from degeneration does not affect retinal ganglion cell death

Braz. j. med. biol. res; 49 (4), 2016
After a traumatic injury to the central nervous system, the distal stumps of axons undergo Wallerian degeneration (WD), an event that comprises cytoskeleton and myelin breakdown, astrocytic gliosis, and overexpression of proteins that inhibit axonal regrowth. By contrast, injured neuronal cell bodies sho...

Effect of magnesium ion on human osteoblast activity

Braz. j. med. biol. res; 49 (7), 2016
Magnesium, a promising biodegradable metal, has been reported in several studies to increase bone formation. Although there is some information regarding the concentrations of magnesium ions that affect bone remodeling at a cellular level, little is known about the effect of magnesium ions on cell gap ju...

Effect of lectin (ScLL) on fibroblasts stimulated with LPS - an in vitro study

Braz. oral res. (Online); 30 (1), 2016
Abstract: The lectin (ScLL) extracted from the Synadenium carinatum plant has been evaluated as an immunomodulator in diseases such as asthma, neosporosis and leishmaniasis. However, it has not yet been evaluated in the oral cavity. This study evaluated the effect of ScLL on viability, proliferation and ...

Low-intensity laser phototherapy enhances the proliferation of dental pulp stem cells under nutritional deficiency

Braz. oral res. (Online); 30 (1), 2016
Abstract Dental trauma in immature permanent teeth can damage pulp vascularization, which leads to necrosis and cessation of apexogenesis. Studies on tissue engineering using stem cells from human exfoliated deciduous teeth (SHEDs) have yielded promising results. Laser phototherapy (LPT) is able to influ...

Response of a co-culture model of epithelial cells and gingival fibroblasts to zoledronic acid

Braz. oral res. (Online); 30 (1), 2016
Abstract Osteonecrosis of the jaw is an adverse effect of bisphosphonates. While the etiopathogenesis of this condition has been investigated, the interactions and effects of bisphosphonates on oral mucosa cells remain unclear. It is hypothesized that cell culture models, such as co-culture or three-dime...

Cytotoxic effects of new MTA-based cement formulations on fibroblast-like MDPL-20 cells

Braz. oral res. (Online); 30 (1), 2016
Abstract The present study aimed at evaluating the cytotoxic effects of a novel cement called CER on periodontal fibroblast-like cells of mice (MDPL-20), in comparison with different formulations of Mineral Trioxide Aggregate (MTA), by means of the cell viability test (MTT) and cell morphology analysis. ...