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In vitro and in vivo antileishmanial activity of Artemisia annua L. leaf powder and its potential usefulness in the treatment of uncomplicated cutaneous leishmaniasis in humans

Mesa, Luz Estella; Vasquez, Daniel; Lutgen, Pierre; Vélez, Iván Darío; Restrepo, Adriana María; Ortiz, Isabel; Robledo, Sara María.
Rev. Soc. Bras. Med. Trop; 50 (1), 2017
ABSTRACT INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of vari...
Antiprotozoarios/farmacología, Antiprotozoarios/uso terapéutico, Artemisia annua/química, Cricetinae, Leishmania/efectos de los fármacos, Leishmaniasis Cutánea/tratamiento farmacológico, Pruebas de Sensibilidad Parasitaria, Extractos Vegetales/farmacología, Extractos Vegetales/uso terapéutico, Hojas de la Planta/química, Resultado del Tratamiento
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Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C

Tanikawa, Aline Aki; Grotto, Rejane Maria Tommasini; Silva, Giovanni Faria; Ferrasi, Adriana Camargo; Sarnighausen, Valéria Cristina Rodrigues; Pardini, Maria Inês de Moura Campos.
Rev. Soc. Bras. Med. Trop; 50 (1), 2017
Abstract: INTRODUCTION: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. METHODS: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to det...
Plaquetas/química, Hepatitis C Crónica/sangre, Hepatitis C Crónica/complicaciones, Cirrosis Hepática/sangre, Cirrosis Hepática/virología, Persona de Mediana Edad, Factor de Crecimiento Derivado de Plaquetas/análisis, Reacción en Cadena de la Polimerasa, Proteínas Proto-Oncogénicas c-sis/sangre, ARN Mensajero/análisis, Índice de Severidad de la Enfermedad, Factor de Crecimiento Transformador beta1/sangre
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In vivo and in vitro activity of oil extract of garlic (Allium sativum Linnaeus) against Schistosoma japonicum cercariae

Wan, Kang; Wang, Peng; Zhang, Leibo.
Rev. Soc. Bras. Med. Trop; 50 (1), 2017
Abstract: INTRODUCTION: The activity of garlic oil extract against Schistosoma japonicum cercariae was evaluated. METHODS: The in vitro and in vivo cercaricidal activities against S. japonicum larvae were determined. RESULTS: Exposure to ≥ 10-6 (v/v) garlic emulsions for 30 min led to 100% cer...
Cercarias/efectos de los fármacos, Ajo/química, Ratones, Pruebas de Sensibilidad Parasitaria, Extractos Vegetales/farmacología, Schistosoma japonicum/efectos de los fármacos, Factores de Tiempo
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Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

Castro Souza Junior Neto, José de; Estevão, Lígia Reis de Moura; Baratella-Evêncio, Liriane; Vieira, Marcela Gabriela Feitosa; Simões, Ricardo Santos; Florencio-Silva, Rinaldo; Evêncio-Luz, Luís; Evêncio-Neto, Joaquim.
Acta cir. bras; 32 (2), 2017
Abstract Purpose: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. Methods: Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon...
Mastocitos/efectos de los fármacos, Olacaceae/química, Extractos Vegetales/administración & dosificación, Piel/lesiones, Cicatrización de Heridas/efectos de los fármacos, Brasil, Recuento de Células, Modelos Animales de Enfermedad, Fitoterapia/métodos, Piel/patología
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Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Santos, Viviani Teixeira dos; Facco, Gilberto Gonçalves; Ortiz, Hudman Cunha; Silva, Iandara Schettert da.
Acta cir. bras; 32 (2), 2017
Abstract Purpose To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimen...
Materiales Biocompatibles/uso terapéutico, Regeneración Ósea, Aceite de Ricino/química, Durapatita/uso terapéutico, Fémur, Fijación Interna de Fracturas/métodos, Vidrio/química, Durapatita/química, Materiales Biocompatibles/química, Fijadores Internos, Modelos Animales, Distribución Aleatoria, Ratas Wistar
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Small cell lung cancer associated with multiple paraneoplastic syndromes

Franco, Diana L.; Thomas, Leslie.
Biomédica (Bogotá); 37 (1), 2017
Abstracts We report the case of a patient presenting with multiple severe electrolyte disturbances who was subsequently found to have small cell lung cancer. Upon further evaluation, she demonstrated three distinct paraneoplastic processes, including the syndrome of inappropriate antidiuretic hormone, Fa...
Neoplasias Pulmonares/etiología, Neurofisinas/fisiología, Síndromes Paraneoplásicos/etiología, Precursores de Proteínas/fisiología, Carcinoma Pulmonar de Células Pequeñas/complicaciones, Vasopresinas/fisiología, Factor-23 de Crecimiento de Fibroblastos, Neoplasias Pulmonares/patología, Neurofisinas/química, Neurofisinas/genética, Precursores de Proteínas/química, Precursores de Proteínas/genética, Carcinoma Pulmonar de Células Pequeñas/patología, Vasopresinas/química, Vasopresinas/genética
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Síntesis de nanopartículas de ácido poliláctico cargadas con antibióticos y su actividad antibacteriana contra Escherichia coli O157:H7 y Staphylococcus aureus resistente a meticilina

Herrera, Mónica Tatiana; Artunduaga, Jhon Jhamilton; Ortiz, Claudia Cristina; Torres, Rodrigo Gonzalo.
Biomédica (Bogotá); 37 (1), 2017
Resumen Introducción: Las nanopartículas poliméricas constituyen una herramienta nanotecnológica que podría ayudar a combatir los microorganismos patógenos que han desarrollado resistencia a los antibióticos convencionales. Objetivo: Sintetizar nanopartículas de ácido poliláctico cargadas con...
Antibacterianos/farmacología, Escherichia coli O157/química, Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos, Pruebas de Sensibilidad MicrobianaMétodos, Nanopartículas/química, Ofloxacino/farmacología, Poliésteres/síntesis química, Vancomicina/farmacología, Antibacterianos/química, Ofloxacino/química, Poliésteres/química, Vancomicina/química
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Preliminary analysis of Brazilian Amazonian plant extracts using bench-top assays in a through-put basis aiming the identification of potential antioxidant natural product

Suffredini, Ivana Barbosa; Cavarsan, Ellen Carolina Montagner; Marin, Lucyana Cano; Díaz, Ingrit Elida Collantes; Paciencia, Mateus Luís Barradas; Frana, Sergio Alexandre.
Rev. ciênc. farm. básica apl; 38 (), 2017
Plants are a source of compounds that are used for the treatment of human and veterinary diseases. Brazil is one of the richest countries in the world in terms of biodiversity. The present study evaluated extracts using thin-layer chromatography to identify antioxidant activity and determine the presence...
Extractos Vegetales/análisis, Ecosistema Amazónico, Antioxidantes/química, Annonaceae/química, Brasil, Cromatografía/métodos, Alcaloides, Antraquinonas
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Tear osmolarity and ocular surface parameters in patients with psoriasis

Demirci, Goktug; Erdur, Sevil Karaman; Aydin, Rukiye; Balevi, Ali; Eliacik, Mustafa; Ozsutcu, Mustafa; Olmuscelik, Oktay.
Arq. bras. oftalmol; 80 (1), 2017
ABSTRACT Purpose: The aim of this study was to evaluate tear osmolarity, tear film function, and ocular surface changes in patients with psoriasis. Methods: At a single center, 30 eyes of 30 patients with psoriasis (group 1) and 30 eyes of 30 healthy individuals (group 2) were evaluated using the Ocula...
Estudios de Casos y Controles, Estudios Transversales, Síndromes de Ojo Seco/diagnóstico, Síndromes de Ojo Seco/etiología, Síndromes de Ojo Seco/fisiopatología, Fluoresceína, Concentración Osmolar, Psoriasis/complicaciones, Psoriasis/fisiopatología, Lágrimas/química
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