Results: 3722

Ortho-nitrobenzyl derivatives as potential anti-schistosomal agents

ABSTRACT In the search for new anti-schistosomal agents, a series of fifteen ortho-nitrobenzyl derivatives was assayed in vitro against both the schistosomulum (somule) and adult forms of Schistosoma mansoni. Compounds 8 and 12 showed significant activity against somules at low micromolar concentrations,...

A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties

ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte ...

Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect

ABSTRACT A drug delivery system (DDS) with analgesic and antibacterial properties would be desirable for the local control of post-operatory pain and the prevention for surgical site infection (SSI). The objective of the present study was to evaluate the antinociceptive effect of the combination between ...

Preparation, characterization, and antiproliferative activities of biotin-decorated docetaxel-loaded bovine serum albumin nanoparticles

ABSTRACT The aim of the present study was to characterize biotin-decorated docetaxel-loaded bovine serum albumin nanoparticles (DTX-BIO-BSA-NPs) and evaluate their antiproliferative activity in vitro. The particle size of prepared DTX-BIO-BSA-NPs was found to be always lower than 200 nm, with sizes of 16...

Inquérito de saúde em comunidades ribeirinhas do Amazonas, Brasil

Os inquéritos populacionais de saúde são instrumentos importantes para o reconhecimento de determinantes de morbidades, sobretudo em regiões de grande dispersão demográfica e baixa cobertura do sistema de saúde. O objetivo deste estudo foi apresentar os principais aspectos metodológicos e descrev...

Cyclic flexural fatigue resistance of NiTi Controlled Memory and Blue Technology instruments after torsional preloading

J. appl. oral sci; 26 (), 2018
Abstract Objective The aim of this study was to evaluate the influence of torsional preloading on the cyclic flexural fatigue resistance of thermally treated NiTi instruments. Material and Methods Ten new instruments New Hyflex CM (HF 30.06; Coltene/Whaladent Inc.), Typhoon CM (TYP 30.06; Clinician's...

Long-term microwaving of denture base materials: effects on dimensional, color and translucency stability

J. appl. oral sci; 26 (), 2018
Abstract While the combined effect of microwave irradiation with cleansing solutions on denture base materials has been investigated, the effects of only using microwave irradiation and, more importantly, in a long-term basis, was not studied yet. Objective The purpose of this study was to evaluate the...

Evaluation of maximal lactate steady state in middle-aged hypertensive women

Motriz (Online); 24 (2), 2018
Abstract AIM The aim of this study was to investigate the lactate response in physically inactive hypertensive women submitted to the treadmill maximal lactate steady state (MLSS) protocol. METHODS Twenty-two hypertensive women (40 - 64 years) performed a familiarization period of walking on the treadm...

The acute hypotensive effect of resistance training performed with machines vs free weights in normotensive men

Motriz (Online); 24 (2), 2018
Abstract AIMS To analyze if different resistance training (machine vs free weight) would have different acute hypotensive effect in active and normotensive individuals. METHODS Fifteen male volunteers (39.2±2.5 years) performed two different resistance exercise protocols, one on machinery and one with...