Abstract Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains eNOS in the inactivated state leading to reduced nitric oxide (NO) produc...
Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated the potential of host defense peptides clavanins A...
Exhaled Nitric Oxide fraction measurement is a new method for the evaluation of respiratory diseases. It has good correlation with airway inflammation and decreases with the administration of corticosteroids. It is useful as a complement for the diagnosis of asthma, Chronic Obstructive Pulmonary Disease,...
Resumo Fundamento As células progenitoras endoteliais (CPEs) desempenham um papel importante na manutenção da função endotelial. A síndrome metabólica (SM) está associada à disfunção das CPEs. Embora o exercício físico tenha um impacto benéfico na atividade das CPEs, seu mecanismo ainda n...
Reactive oxygen species are implicated in multiple pathological conditions including erectile dysfunction. This study evaluated the in vitro and in vivo antioxidant potential of the methanolic extracts of Inula glomerata and Salacia kraussii. The plant materials were pulverized and extracted with methan...
Inula/química,
Asteraceae/química,
Salacia/química,
Celastraceae/química,
Antioxidantes/química,
Antioxidantes/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Especies Reactivas de Oxígeno,
Extractos Vegetales/química,
Extractos Vegetales/farmacología,
Compuestos Fenólicos/análisis,
Flavonoides/análisis,
Fitoquímicos/análisis,
Óxido Nítrico/metabolismo,
Ácidos Sulfónicos/metabolismo,
Benzotiazoles/metabolismo,
Ratas Sprague-Dawley
Background: Ayanin (3,7,4’-Tri-O-methylquercetin) and 3,7-Di-O-methylquercetin (DMQ) are the main active metabolites isolated by bioguided fractionation from Croton schiedeanus, species known popularly in Colombia as “almizclillo”, which has been studied in experimental models in rats, exerting ...
Oliveira, Karla A;
Torquato, Ricardo J. S;
Lustosa, Daniela C. G. Garcia;
Ribeiro, Tales;
Nascimento, Bruno W. L;
Oliveira, Lilian C. G. de;
Juliano, Maria A;
Paschoalin, Thaysa;
Lemos, Virginia S;
Araujo, Ricardo N;
Pereira, Marcos H;
Tanaka, Aparecida S.
Triatoma infestans (Hemiptera: Reduviidae) is a hematophagous insect and the main vector of Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). In the present study, the authors investigated whether a serine protease activity from the saliva of T. infestans has a role in vasomotor modulation, and in th...
Damasceno-Sá, João Cláudio;
de Souza, Fernanda Silva;
dos Santos, Thiago Alves Teixeira;
de Oliveira, Fábio Conceição;
da Silva, Maria de Fátima Sarro;
Dias, Raul Ramos Furtado;
de Souza, Wanderley;
Arnholdt, Andrea Cristina Veto;
Seabra, Sergio Henrique;
DaMatta, Renato Augusto.
BACKGROUND Toxoplasma gondii causes toxoplasmosis and is controlled by activated macrophages. However, infection of macrophages by tachyzoites induces TGF-β signaling (TGF-s) inhibiting nitric oxide (NO) production. NO inhibition may be a general escape mechanism of distinct T. gondii strains. OBJE...
Andrade, Tadeu Uggere de;
Schumacker, Karolina Silva;
Schumacker, Karina Silva;
Coutinho, Gabriela;
Rezende, Mahira Sabino;
Ronchi, Silas Nascimento;
Kalil, Ieda Carneiro;
Silva-Cutini, Mirian de Almeida;
Lima, Ewelyne Miranda de;
Maia, June Ferreira;
Brasil, Girlandia Alexandre.
Probiotic consumption promotes numerous health benefits. The aim of this study is 1) to evaluate the antihypertensive effect of kefir in a hypertension rat model caused by the administration of the nitric oxide synthesis inhibitor, L-NAME, and 2) to evaluate the acute angiotensin converting enzyme (ACE) ...
