Gastric cancer (GC) is the third most lethal type of cancer worldwide. Single nucleotide polymorphisms (SNPs) in regulatory sites or coding regions can modify the expression of genes involved in gastric carcinogenesis, as ERBB2, which encodes for the tyrosine-kinase receptor HER-2. The aim of this work w...
The prevalence of relevant oncogenic drivers in lung adenocarcinoma varies in our region and data on clinical outcomes is scarce. The objective of the study was to describe the prevalence of KRAS, BRAF and EGFR mutations and ALK translocations in patients with advanced lung adenocarcinoma, and to depict ...
Adenocarcinoma/genética,
Adenocarcinoma/mortalidad,
Adenocarcinoma/patologÃa,
Quinasa de Linfoma Anaplásico/genética,
Argentina/epidemiologÃa,
Biopsia,
Genes erbB-1/genética,
InmunohistoquÃmica,
Hibridación Fluorescente in Situ,
Estimación de Kaplan-Meier,
Neoplasias Pulmonares/genética,
Neoplasias Pulmonares/mortalidad,
Neoplasias Pulmonares/patologÃa,
Mutación,
Estudios Prospectivos,
ProteÃnas Proto-Oncogénicas B-raf/genética,
EstadÃsticas no Paramétricas
Adenocarcinoma/etiologÃa,
Adenocarcinoma/genética,
Adenocarcinoma/microbiologÃa,
Consumo de Bebidas Alcohólicas/efectos adversos,
Estudios de Casos y Controles,
Escolaridad,
Predisposición Genética a la Enfermedad,
Infecciones por Helicobacter,
Persona de Mediana Edad,
Medición de Riesgo,
Factores de Riesgo,
Fumar/efectos adversos,
Neoplasias Gástricas/etiologÃa,
Neoplasias Gástricas/genética,
Neoplasias Gástricas/microbiologÃa,
Encuestas y Cuestionarios
ABSTRACT Background: MTUYH and OGG1 genes have importance in the base excision repair systems of oxidized DNA bases. Modification of the tissue expression of these genes is related to the increased risk of developing colorectal cancer. Aim: To evaluate the tissue expression of MUTYH and OGG1 comparin...
Wielandt, Ana MarÃa;
Villarroel, Cynthia;
Hurtado, Claudia;
Simian, Daniela;
Zamorano, Diego;
MartÃnez, Maripaz;
Castro, Magdalena;
Vial, MarÃa Teresa;
Kronberg, Udo;
López-Kostner, Francisco.
Background: Colorectal cancer (CRC) is an heterogeneous disease. Three carcinogenic pathways determine its molecular profile: microsatellite instability (MSI), chromosomal instability (CIN) and CpG island methylator phenotype (CIMP). Based on the new molecular classification, four consensus CRC molecular...
Adenocarcinoma/genética,
Biomarcadores de Tumor/genética,
Neoplasias Colorrectales/genética,
Metilación de ADN/genética,
ADN de Neoplasias/genética,
Inestabilidad de Microsatélites,
Adenocarcinoma/patologÃa,
Chile,
Neoplasias Colorrectales/patologÃa,
Consenso,
Mutación,
Fenotipo,
Estudios Prospectivos
Carvalho, Thais Inácio de;
Novais, Paulo Cezar;
Lizarte Neto, Fermino Sanches;
Sicchieri, Renata Danielle;
Rosa, Marcella Suelma Torrecillas;
Carvalho, Camila Albuquerque Mello de;
Tirapelli, Daniela Pretti da Cunha;
Peria, Fernanda Maris;
Rocha, José Joaquim Ribeiro da;
Féres, Omar.
Abstract Purpose: To evaluate the expression of EGFR, KRAS genes, microRNAs-21 and 203 in colon and rectal cancer samples, correlated with their age at diagnosis, histological subtype, value of pretreatment CEA, TNM staging and clinical outcome. Methods: Expression of genes and microRNAs by real time ...
Adenocarcinoma/genética,
Neoplasias Colorrectales/genética,
Expresión Génica,
Genes erbB-1,
Genes ras,
MicroARNs/análisis,
ProteÃnas Proto-Oncogénicas p21(ras)/análisis,
Adenocarcinoma/tratamiento farmacológico,
Adenocarcinoma/patologÃa,
Factores de Edad,
Biomarcadores de Tumor/análisis,
AntÃgeno Carcinoembrionario/análisis,
Neoplasias Colorrectales/tratamiento farmacológico,
Neoplasias Colorrectales/patologÃa,
Estadificación de Neoplasias,
Estudios Prospectivos,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Resultado del Tratamiento
El cáncer gástrico presenta una de las tasas de mortalidad más importante a nivel mundial, situación que es aún más preocupante en Colombia cuyas tasas son históricamente altas y en nuestro contexto regional particularmente para Boyacá, en la región nororiental de Colombia, es la primera causa d...
Abstract: Approximately 90% of the world population is infected by Epstein-Barr virus (EBV). Usually, it infects B lymphocytes, predisposing them to malignant transformation. Infection of epithelial cells occurs rarely, and it is estimated that about to 10% of gastric cancer patients harbor EBV in their ...
O câncer de reto é o segundo tumor mais comum no intestino grosso correspondendo a um terço do total de casos de câncer colorretal (CCR). Pacientes com câncer de reto em estádios II e III são tratados com radioquimioterapia neoadjuvante seguida de ressecção cirúrgica do tumor. Análises das peÃ...
Neoplasias del Recto/terapia,
Metilación,
Terapia Neoadyuvante,
Genes erbB-1,
Neoplasias del Recto/patologÃa,
Adenocarcinoma/terapia,
Adenocarcinoma/patologÃa,
VesÃculas Extracelulares/patologÃa,
Neoplasias del Recto/genética,
Adenocarcinoma/genética,
VesÃculas Extracelulares/genética,
Biomarcadores,
ProteÃnas/análisis,
GlicoproteÃnas de Membrana/análisis,
Supervivencia Celular,
Proliferación Celular,
Invasividad Neoplásica,
Resultado del Tratamiento,
Expresión Génica,
LÃnea Celular
Gastric cancer is the forth malignancy in frequency in the world. In the northern Brazil is the second neoplasia most frequent in males and the third most frequent in females. Genetic and epigenetic alterations are evolved on gastric carcinogenesis and DNA methylation is the epigenetic alteration better ...
