LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients

Marchini, JFM; Pinto, MR; Novaes, GC; Badran, AV; Pavão, RB; Figueiredo, GL; Lago, IM; Lima-Filho, MO; Lemos, DC; Tonani, M; Antloga, CM; Oliveira, L; Lorenzi, JC; Marin-Neto, JA.

Braz. j. med. biol. res; 50 (1), 2017

Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern. Populations with higher degrees of genetic admixture may have increased prev...

Subfamilia B de Transportador de Casetes de Unión a ATP/genética, Alelos, Arildialquilfosfatasa/genética, Aspirina/farmacología, Plaquetas/efectos de los fármacos, Enfermedad de la Arteria Coronaria/tratamiento farmacológico, Enfermedad de la Arteria Coronaria/genética, Citocromo P-450 CYP2C19/genética, Quimioterapia Combinada, Genotipo, Intervención Coronaria Percutánea, Inhibidores de Agregación Plaquetaria/farmacología, Polimorfismo Genético, Estudios Prospectivos, Ticlopidina/análogos & derivados, Ticlopidina/farmacología

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Paraoxonase 1 gene polymorphisms and enzyme activities in coronary artery disease and its relationship to serum lipids and glycemia

Fridman, Osvaldo; Gariglio, Luis; Riviere, Stephanie; Porcile, Rafael; Fuchs, Alicia; Potenzoni, Miguel.

Arch. cardiol. Méx; 86 (4), 2016

Abstract Objectives Oxidative stress and inflammation are important processes in development of atherosclerosis. Paraoxonase 1 (PON1) is a bioscavenger enzyme associated with inflammation and oxidative stress. We evaluate the association of two single nucleotide polymorphisms in PON1 gene, and enzyme ac...

Arildialquilfosfatasa/genética, Glucemia/análisis, Estudios de Casos y Controles, Colesterol/sangre, Enfermedad de la Arteria Coronaria/sangre, Enfermedad de la Arteria Coronaria/enzimología, Enfermedad de la Arteria Coronaria/genética, Polimorfismo de Nucleótido Simple, Triglicéridos/sangre

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Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score

Souza-Nogueira, Andre de; Camargo, Alissana Ester; Remondi, Felipe Assan; Paoliello, Monica Maria Bastos; Richter, Rebecca J; Furlong, Clement E; Barbosa, Decio Sabbatini; Maes, Michael; Moreira, Estefania Gastaldello.

Arch. endocrinol. metab. (Online); 60 (5), 2016

ABSTRACT Objective Paraoxonase 1 (PON1) polymorphisms are associated with an increased susceptibility to cardiovascular disease. PON1 Q192R polymorphism (rs662) partially determine PON1 hydrolytic activity and protect against oxidation of LDL and HDL. This study aimed to delineate the association of PO...

Arildialquilfosfatasa/sangre, Arildialquilfosfatasa/genética, Aterosclerosis/genética, HDL-Colesterol/sangre, LDL-Colesterol/sangre, Estudios Transversales, Interacción Gen-Ambiente, Estudios de Asociación Genética, Genotipo, Hidrólisis, Modelos Logísticos, Polimorfismo Genético, Valores de Referencia, Medición de Riesgo/métodos, Factores de Riesgo, Factores Sexuales, Fumar/efectos adversos, Triglicéridos/sangre

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The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia

Argani, Hassan; Ghorbanihaghjo, Amir; Vatankhahan, Hamid; Rashtchizadeh, Nadereh; Raeisi, Sina; Ilghami, Hadi.

Säo Paulo med. j; 134 (3), 2016

ABSTRACT: CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG...

Antioxidantes/uso terapéutico, Arildialquilfosfatasa/sangre, Colesterol/sangre, Método Doble Ciego, Extracto de Semillas de Uva/uso terapéutico, Hiperlipidemias/tratamiento farmacológico, Lipoproteínas HDL/sangre, Lipoproteínas LDL/sangre, Fitoterapia, Placebos, Triglicéridos/sangre

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