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Synthesis and characterization of a cysteine xyloglucan conjugate as mucoadhesive polymer

Bhalekar, Mangesh; Sonawane, Savita; Shimpi, Shamkant.
Braz. j. pharm. sci; 49 (2), 2013
The aim of this study was to improve the mucoadhesive potential of xyloglucan polymer by the covalent attachment of cysteine as thiol moiety. The parent polymer xyloglucan was chemically modified by introducing sulphydryl bearing compound L-cysteine HCl. Different batches of xyloglucan-cysteine conjugate...
Cisteína/análisis, /síntesis química, Polímeros, /química
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Rational use of antioxidants in solid oral pharmaceutical preparations

Celestino, Maísa Teodoro; Magalhães, Uiaran de Oliveira; Fraga, Aline Guerra Manssour; Carmo, Flávia Almada do; Lione, Viviane; Castro, Helena Carla; Sousa, Valeria Pereira de; Rodrigues, Carlos Rangel; Cabral, Lucio Mendes.
Braz. j. pharm. sci; 48 (3), 2012
Antioxidants are currently used as efficient excipients that delay or inhibit the oxidation process of molecules. Excipients are often associated with adverse reactions. Stability studies can guide the search for solutions that minimize or delay the processes of degradation. The ability to predict oxidat...
Utilización de Medicamentos/clasificación, Antioxidantes/análisis, Preparaciones Farmacéuticas, Administración Oral, Excipientes/clasificación, Hidroxitolueno Butilado/farmacocinética, Hidroxianisol Butilado/farmacocinética, Galato de Propilo/farmacocinética, Cisteína/farmacocinética, Simvastatina/análisis, Cetoconazol/análisis
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