This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of the...
Antineoplásicos/química,
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Organismos Acuáticos/química,
Biotecnología/métodos,
Brentuximab Vedotina,
Citarabina/química,
Desarrollo de Medicamentos/métodos,
Descubrimiento de Drogas,
Furanos/química,
Inmunoconjugados/química,
Inmunoconjugados/farmacología,
Inmunoconjugados/uso terapéutico,
Cetonas/química,
Neoplasias/tratamiento farmacológico,
Océanos y Mares,
Trabectedina/química
ABSTRACT Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprec...
Debido a la gran problemática mundial de la resistencia bacteriana a los antibióticos, es necesaria la búsqueda continua de nuevas moléculas con características antimicrobianas. Este estudio evaluó el efecto antibacteriano y antifúngico de un extracto hexánico proveniente de la raíz de Salvia ap...
Abstract: The relationships between health and socioeconomic development are diverse. These relationships find in the health economic complex a privileged ground for expression. The importance of health technologies increased exponentially since the middle of the 20th century, affecting health systems in...
Abstract: This article discusses the relations between healthcare systems and the pharmaceutical industry, focusing on state support for pharmaceutical innovation. The study highlights the experiences of the United States, United Kingdom, and Germany, developed countries and paradigms of modern health sy...
Abstract: The Brazilian pharmaceutical industry is heavily dependent on external sources of inputs, capital, and technology. However, the emergence of technological opportunities and the development of biotechnology and the decline of the patent boom and resulting advances by generic drugs have opened wi...
BACKGROUND: Novel, in silico-designed anticancer compounds were synthesized in our laboratory namely, 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16). These compounds were designed to have improved bioavailability when com...
Antineoplásicos/farmacología,
Inhibidores de Anhidrasa Carbónica/farmacología,
Simulación por Computador,
Eritrocitos/efectos de los fármacos,
Estradiol/análogos & derivados,
Estrenos/farmacología,
Sulfonamidas/farmacología,
Antineoplásicos/farmacocinética,
Anhidrasa Carbónica II/efectos de los fármacos,
Inhibidores de Anhidrasa Carbónica/farmacocinética,
Proteínas Portadoras/farmacocinética,
Proteínas Portadoras/farmacología,
Eritrocitos/ultraestructura,
Estradiol/farmacocinética,
Estradiol/farmacología,
Estradiol/toxicidad,
Estrenos/farmacocinética,
Hemólisis/efectos de los fármacos,
Sulfonamidas/farmacocinética,
Sulfonamidas/toxicidad,
Disponibilidad Biológica,
Descubrimiento de Drogas,
Microscopía Electrónica de Rastreo,
Investigación Cualitativa,
Temperatura
