This study was set to investigate the effect of gum Arabic (G.A.) on diabetic kidney disease. We divided sixty male Sprague rats randomly into six groups. Normal control, normal rats treated with G.A., untreated diabetic rats, diabetic rats treated with insulin, diabetic rats treated with G.A., and diabe...
Nefropatías Diabéticas/prevención & control,
Goma Arábiga/administración & dosificación,
Goma Arábiga/farmacología,
Nefropatías Diabéticas/patología,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/patología,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Estrés Oxidativo/efectos de los fármacos,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Ratas Sprague-Dawley,
Riñón/efectos de los fármacos,
Inyecciones Intraperitoneales
Diabetes Mellitus (DM) is a condition marked by hyperglycaemia that causes systemic complications, including urinary vesicle dysfunction due to oxidative stress. Further, antioxidants, as well as alpha lipoic acid (ALA), may be a response to this pathological condition. The present study verified the act...
Diabetes mellitus is a serious disease with a high incidence of occurrence in our community. Gum Arabic (GA) is a branched-chain polysaccharide which has strong antioxidant properties, and has been used to reduce the experimental toxicity. Yet, the effects of GA on testicular tissue in type I diabetic ra...
Background: The harmful effects of type 2 diabetes mellitus and its complications have become a major global public health problem. In this study, the effects of Momordica charantia saponins (MCS) on lipid metabolism, oxidative stress, and insulin signaling pathway in type 2 diabetic rats were investigat...
Diabetes Mellitus Experimental/tratamiento farmacológico,
Momordica charantia/química,
Saponinas/uso terapéutico,
Saponinas/farmacología,
Ratas Wistar,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Resistencia a la Insulina,
Lípidos,
Glucemia/efectos de los fármacos,
Peso Corporal,
Hígado/efectos de los fármacos,
Páncreas/efectos de los fármacos
Wunderlich, A L M;
Azevedo, S C S F;
Yamada, L A;
Bataglini, C;
Previate, C;
Campanholi, K S S;
Pereira, P C S;
Caetano, W;
Kaplum, V;
Nakamura, C V;
Nakanishi, A B S;
Comar, J F;
Pedrosa, M M D;
Godoi, V A F.
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditio...
Clorofila/administración & dosificación,
Clorofila/análogos & derivados,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Quimioterapia Combinada,
Metabolismo Energético/efectos de los fármacos,
Glucólisis/efectos de los fármacos,
Glucólisis/fisiología,
Hígado/patología,
Hígado/fisiopatología,
Estrés Oxidativo/efectos de los fármacos,
Estrés Oxidativo/fisiología,
Fotoquimioterapia,
Fármacos Fotosensibilizantes/administración & dosificación,
Ratas Wistar
Abstract Objective: This study evaluated the effects of local vitamin C treatment on tissue advanced glycation end products (AGE), interleukin (IL)-6, 8-hydroxy-2-deoxyguanosine (8-OHdG), and matrix metalloproteinases (MMP)-8 in tissues; serum C-terminal telopeptide fragments (CTX); and alveolar bone lo...
Pérdida de Hueso Alveolar,
Ácido Ascórbico/administración & dosificación,
Colágeno Tipo I,
Diabetes Mellitus Experimental/complicaciones,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Productos Finales de Glicación Avanzada,
Interleucina-6,
Metaloproteinasa 8 de la Matriz,
Estrés Oxidativo,
Péptidos,
Periodontitis/tratamiento farmacológico,
Ratas Sprague-Dawley
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear...
Abstract Purpose: To evaluate the effects of Dexmedetomidine (Dex) on spinal pathology and inflammatory factor in a rat model of Diabetic neuropathic pain (DNP). Methods: The rats were divided into 3 groups (eight in each group): normal group (N group), diabetic neuropathic pain model group (DNP group)...
Agonistas de Receptores Adrenérgicos alfa 2/farmacología,
Western Blotting,
Dexmedetomidina/farmacología,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Neuropatías Diabéticas/tratamiento farmacológico,
Neuropatías Diabéticas/patología,
Modelos Animales de Enfermedad,
Interleucina-1beta/análisis,
Interleucina-1beta/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Proteína con Dominio Pirina 3 de la Familia NLR/análisis,
Proteína con Dominio Pirina 3 de la Familia NLR/efectos de los fármacos,
Conducción Nerviosa/efectos de los fármacos,
Umbral del Dolor,
Distribución Aleatoria,
Receptores Purinérgicos P2X4/análisis,
Columna Vertebral/efectos de los fármacos,
Nervio Sural/efectos de los fármacos,
Factores de Tiempo
ABSTRACT BACKGROUND: Serotonin (5-HT) is present in the epithelial enterochromaffin cells (EC), mast cells of the lamina propria and enteric neurons. The 5-HT is involved in regulating motility, secretion, gut sensation, immune system and inflammation. OBJECTIVE: Evaluate the effects of diabetes and ...
Antioxidantes/administración & dosificación,
Apoptosis/efectos de los fármacos,
Caspasa 3/metabolismo,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/patología,
Suplementos Dietéticos,
Inmunohistoquímica,
Células Intersticiales de Cajal/efectos de los fármacos,
Células Intersticiales de Cajal/patología,
Mucosa Intestinal/efectos de los fármacos,
Yeyuno/efectos de los fármacos,
Yeyuno/patología,
Quercetina/administración & dosificación,
Ratas Wistar,
Serotonina/metabolismo
Abstract Purpose: To investigated the effects of ginsenoside Rb1 on diabetic retinopathy in streptozotocin-induced diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (80 mg/kg) in male Wistar rats. Ginsenoside Rb1 (20, 40 mg/kg) was injected (i.p.) on...
