Results: 37

Non-pharmacological motor-cognitive treatment to improve the mental health of elderly adults

SUMMARY OBJECTIVE: To propose a program of physical-cognitive dual task and to measure its impact in Chilean institutionalized elderly adults. METHOD: Experimental design study with pre and post-intervention evaluations, measuring the cognitive and depressive levels by means of the Pfeiffer test and th...

Egocentric and allocentric spatial memory in healthy aging: performance on real-world tasks

Braz. j. med. biol. res; 52 (4), 2019
Although normal aging has been related to several cognitive difficulties, other processes have been studied less, such as spatial memory. Our aim was to compare egocentric and allocentric memory in an elderly population using ecological tasks. Twenty-eight cognitively unimpaired participants performed Eg...

A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment

Braz. j. med. biol. res; 52 (5), 2019
This study aimed to explore the structural and functional characteristics of the neural network of resting-state brain activities in patients with amnestic mild cognitive impairment (aMCI) by functional magnetic resonance imaging (fMRI) technology. Resting state fMRI scanning was performed on 10 clinical...

Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway

Braz. j. med. biol. res; 52 (11), 2019
Oxiracetam (ORC) is a commonly used nootropic drug for improving cognition and memory impairments. The therapeutic effect and underlying mechanism of ORC in vascular dementia (VaD) treatment remain unknown. In this study, 3-month-old male Sprague-Dawley rats with permanent bilateral common carotid artery...

Alterações vasculares e declínio cognitivo em idosos hipertensos com apnéia obstrutiva do sono
Vascular changes and cognitive decline in hypertensive elderly people with obstructive sleep apnea

A população de idosos cresce rapidamente no Brasil. As prevalências de hipertensão arterial, apneia obstrutiva do sono (AOS) e distúrbios cognitivos são altas nesta população. O objetivo deste estudo foi verificar se existe uma associação entre apnéia obstrutiva do sono e desempenho cognitivo ...

BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline

Arq. neuropsiquiatr; 76 (11), 2018
ABSTRACT Elderly people are at a high risk of developing vitamin D (VitD) deficiency due to both decreased intake and cutaneous synthesis. Most of the biological actions of VitD are mediated by the vitamin D receptor (VDR), which is present in neurons and glial cells of the hippocampus, and in the cortex...

Twenty-five years since the identification of the first SCA gene: history, clinical features and perspectives for SCA1

Arq. neuropsiquiatr; 76 (8), 2018
ABSTRACT Spinocerebellar ataxias (SCA) are a clinically and genetically heterogeneous group of monogenic diseases that share ataxia and autosomal dominant inheritance as the core features. An important proportion of SCAs are caused by CAG trinucleotide repeat expansions in the coding region of different ...

Performances on the Timed Up and Go Test and subtasks between fallers and non-fallers in older adults with cognitive impairment

Arq. neuropsiquiatr; 76 (6), 2018
ABSTRACT This work aimed to compare performances on the Timed Up and Go (TUG) test and its subtasks between faller and non-faller older adults with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). A prospective study was conducted, with 38 older adults with MCI and 37 with mild AD. Part...

Funcionamiento cognitivo en adultos mayores: rol de la reserva cognitiva, apoyo social y depresión

Rev. méd. Chile; 146 (3), 2018
Background: Cognitive reserve (CR) is a protective factor in aging. Depression and perceived social support are associated with cognitive performance in older adults. However, their role in the relationship between CR and cognitive functioning is less clear. Aim: To determine the relationship between CR...

Association between executive and food functions in the acute phase after stroke

Arq. neuropsiquiatr; 76 (3), 2018
ABSTRACT Purpose To investigate potential associations among executive, physical and food functions in the acute phase after stroke. Methods This is a cross-sectional study that evaluated 63 patients admitted to the stroke unit of a public hospital. The exclusion criteria were other neurological and/or...